scholarly journals Intracellular distribution of pentobarbital sodium in rat brain

1958 ◽  
Author(s):  
◽  
Carol Jean Oen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rat Brain ◽  
Major Effect ◽  
Cellular Component ◽  
Intracellular Distribution ◽  
Brain Cells ◽  
Pentobarbital Sodium ◽  
The Central Nervous System ◽  
The Way

"The major effect of the barbiturates is depression of the central nervous system, but the way in which these drugs exert their effect is not yet well understood...As the biochemical functions of the cell and its various parts become better understood, it is of interest to relate the actions of t a drug to some particular function (Reiner and Gellhorn, 1956). If it were found that barbiturate were localized by a particular cellular component, this might mean that its effect was rendered through some function of that particular component. Consequently, this study was undertaken to determine the intracellular distribution of a particular barbiturate, pentobarbital sodium, within rat brain cells."--Introduction

scholarly journals Further Investigations on the Function of the Electrical Organ of the Skate

1889 ◽  
Vol 1 (1) ◽  
pp. 74-74 ◽  
Author(s):  
Burdon Sanderson ◽  
F. Gotch
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electromotive Force ◽  
Electric Organ ◽  
Physiological Laboratory ◽  
The Central Nervous System ◽  
Work Done ◽  
The Way

During the month of September, 1888, we availed ourselves of the facilities afforded by the Laboratory for the purpose of continuing the investigations began by us the year before, of the function of the electrical organ of the skate. In the record of the work done by us in 1887 at St. Andrews, published in the Journal of Physiology, vol. ix, p. 137, we indicated several new lines of investigation which we hoped to pursue if the opportunity offered. Two of these indications we have now been able to fulfil satisfactorily, namely, those relating to the electromotive force of the shock, and to the way in which the function of the electric organ is controlled and influenced by the central nervous system. In the first of these inquiries, we used apparatus which was brought from the Oxford Physiological Laboratory, and temporarily fitted up in the room at Plymouth, which is set apart for physiological researches, and which we found well adapted for this purpose. For the second, a large number of experiments and consequently a considerable number of fish were requisite. Forty skates of various species (Raia Batis, R. clavata, R. microcellata, and R. maculata) were supplied to us and used in our researches, of which the result will shortly be ready for publication.We desire to express in the strongest terms our appreciation of the advantages afforded by the Laboratory for physiological researches. We would also record our personal obligation to the Director for his uniform courtesy and untiring zeal in obtaining for us, in spite of considerable difficulties, the material required for our work.

Imidazo[1,2-b]pyridazines. XIII. Syntheses and Central Nervous System Activities of Some 2-Benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-Butyl and cyclohexyl)-3-methoxy(acylaminomethyl and dimethylaminomethyl)-6-(variously substituted)imidazo[1,2-b]pyridazines

1992 ◽  
Vol 45 (8) ◽  
pp. 1281 ◽  
Author(s):  
GB Barlin ◽  
LP Davies ◽  
SJ Ireland ◽  
JK Zhang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rat Brain ◽  
Brain Membrane ◽  
The Central Nervous System

6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethy1)-2-benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)imidazo[1,2-b] pyridazines have been prepared and examined for activity in the central nervous system. Of these, 2-benzyl-3-methoxy-6-(3'-methoxybenzylamino) imidazo[1,2-b]pyridazine (IC50 88nM) bound most strongly to rat brain membrane. In general, the order of activity for groups at the 2-position was Ph > PhCH2 > PhCH2CH2 > C6H4Ph-p, 6'-methylnaphthalen-2'-yl, c-C6H11 or But.

scholarly journals THE INTRACELLULAR DISTRIBUTION OF LANSING POLIOMYELITIS VIRUS IN THE CENTRAL NERVOUS SYSTEM OF INFECTED COTTON RATS

1952 ◽  
Vol 96 (2) ◽  
pp. 121-136 ◽  
Author(s):  
Carlton E. Schwerdt ◽  
Arthur B. Pardee
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intracellular Distribution ◽  
Particle Fraction ◽  
Poliomyelitis Virus ◽  
Cotton Rats ◽  
The Central Nervous System

A procedure has been described for the centrifugal fractionation of the cellular particulate components of CNS tissue infected with poliomyelitis virus. A study of the distribution of infectivity among these components revealed that approximately four-fifths of the virus is found free in the submicroscopic particle fraction. The validity of the conclusion that the virus is located in this fraction of the intact neuron is discussed.

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