Erythrocyte Membrane Damage in Hemolytic Anemias

1990 ◽  
pp. 455-473 ◽  
Author(s):  
Augusta Brovelli
Keyword(s):  
Erythrocyte Membrane ◽  
Membrane Damage

The effects of the caffeic acid phenethyl ester(CAPE) on erythrocyte membrane damage after hind limb ischaemia–reperfusion

2004 ◽  
Vol 22 (5) ◽  
pp. 287-290 ◽  
Author(s):  
Lülüfer Tamer ◽  
Nehir Sucu ◽  
Bahadır Ercan ◽  
Ali Ünlü ◽  
Mukadder Çalıkoğlu ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Erythrocyte Membrane ◽  
Hind Limb ◽  
Membrane Damage ◽  
Caffeic Acid Phenethyl Ester ◽  
Limb Ischaemia ◽  
Ischaemia Reperfusion

scholarly journals Toxic effect of puromycin on erythrocyte membranes which is unrelated to inhibition of protein synthesis

Blood ◽  
1975 ◽  
Vol 45 (1) ◽  
pp. 21-27 ◽  
Author(s):  
ER Burka ◽  
SK Ballas ◽  
SM Sabesin
Keyword(s):  
Protein Synthesis ◽  
Cell Membrane ◽  
Toxic Effect ◽  
Erythrocyte Membrane ◽  
Membrane Damage ◽  
Erythrocyte Membranes ◽  
Erythroid Cell ◽  
Ultrastructural Changes ◽  
Direct Toxic Effect ◽  
Increased Susceptibility

Abstract Exposure of rabbit or human erythrocytes to concentrations of puromycin as low as 7 x 10(-4)M for 2 hr causes damage to the cell membrane, as evidenced by increased susceptibility of the cells to hyposmotic lysis, increased cell rigidity, and ultrastructural changes consistent with severe membrane damage. Puromycin causes a concentration-dependent internalization of the erythrocyte membrane, resulting in vacuolization of the cells, at concentrations between 7 x 10(-4) M and 10(-2) M. Since the erythrocyte does not synthesize protein, the data indicate that puromycin has a direct toxic effect on erythroid cell membranes which is unrelated to its action in inhibiting the synthesis of protein.

scholarly journals Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage

2015 ◽  
Vol 174 ◽  
pp. 410-418 ◽  
Author(s):  
Phanuel Saroni Arwa ◽  
Maria Luiza Zeraik ◽  
Valdecir Farias Ximenes ◽  
Luiz Marcos da Fonseca ◽  
Vanderlan da Silva Bolzani ◽  
...  
Keyword(s):  
Erythrocyte Membrane ◽  
Oxidative Burst ◽  
Human Erythrocyte ◽  
Membrane Damage ◽  
Human Erythrocyte Membrane ◽  
Redox Active ◽  
Neutrophil Oxidative Burst

scholarly journals Toxic effect of puromycin on erythrocyte membranes which is unrelated to inhibition of protein synthesis

Blood ◽  
1975 ◽  
Vol 45 (1) ◽  
pp. 21-27
Author(s):  
ER Burka ◽  
SK Ballas ◽  
SM Sabesin
Keyword(s):  
Protein Synthesis ◽  
Cell Membrane ◽  
Toxic Effect ◽  
Erythrocyte Membrane ◽  
Membrane Damage ◽  
Erythrocyte Membranes ◽  
Erythroid Cell ◽  
Ultrastructural Changes ◽  
Direct Toxic Effect ◽  
Increased Susceptibility

Exposure of rabbit or human erythrocytes to concentrations of puromycin as low as 7 x 10(-4)M for 2 hr causes damage to the cell membrane, as evidenced by increased susceptibility of the cells to hyposmotic lysis, increased cell rigidity, and ultrastructural changes consistent with severe membrane damage. Puromycin causes a concentration-dependent internalization of the erythrocyte membrane, resulting in vacuolization of the cells, at concentrations between 7 x 10(-4) M and 10(-2) M. Since the erythrocyte does not synthesize protein, the data indicate that puromycin has a direct toxic effect on erythroid cell membranes which is unrelated to its action in inhibiting the synthesis of protein.

Investigation of erythrocyte membrane damage under the action of γ radiation in a wide dose range using electroporation

2008 ◽  
Vol 5 (2) ◽  
pp. 127-130 ◽  
Author(s):  
A. P. Kozlov ◽  
E. A. Krasavin ◽  
A. V. Boreyko ◽  
A. P. Chernyaev ◽  
P. Yu. Alekseeva ◽  
...  
Keyword(s):  
Erythrocyte Membrane ◽  
Dose Range ◽  
Membrane Damage ◽  
Γ Radiation

Dye sorption as an indicator of erythrocyte membrane damage and prehemolytic state of erythrocytes

2000 ◽  
Vol 129 (3) ◽  
pp. 306-308 ◽  
Author(s):  
V. B. Gavrilov ◽  
O. N. Kravchenko ◽  
S. V. Konev
Keyword(s):  
Erythrocyte Membrane ◽  
Membrane Damage ◽  
Dye Sorption

scholarly journals Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, andβ-Actin Alterations: An Unrecognized Triad in Classical Autism

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Lucia Ciccoli ◽  
Claudio De Felice ◽  
Eugenio Paccagnini ◽  
Silvia Leoncini ◽  
Alessandra Pecorelli ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Erythrocyte Membrane ◽  
Biological Markers ◽  
Membrane Damage ◽  
Autism Spectrum ◽  
Erythrocyte Shape ◽  
Oxidative Membrane Damage ◽  
Actin Protein ◽  
Negative Controls ◽  
Age Range

Autism spectrum disorders (ASDs) are a complex group of neurodevelopment disorders steadily rising in frequency and treatment refractory, where the search for biological markers is of paramount importance. Although red blood cells (RBCs) membrane lipidomics and rheological variables have been reported to be altered, with some suggestions indicating an increased lipid peroxidation in the erythrocyte membrane, to date no information exists on how the oxidative membrane damage may affect cytoskeletal membrane proteins and, ultimately, RBCs shape in autism. Here, we investigated RBC morphology by scanning electron microscopy in patients with classical autism, that is, the predominant ASDs phenotype (age range: 6–26 years), nonautistic neurodevelopmental disorders (i.e., “positive controls”), and healthy controls (i.e., “negative controls”). A high percentage of altered RBCs shapes, predominantly elliptocytes, was observed in autistic patients, but not in both control groups. The RBCs altered morphology in autistic subjects was related to increased erythrocyte membrane F2-isoprostanes and 4-hydroxynonenal protein adducts. In addition, an oxidative damage of the erythrocyte membraneβ-actin protein was evidenced. Therefore, the combination of erythrocyte shape abnormalities, erythrocyte membrane oxidative damage, andβ-actin alterations constitutes a previously unrecognized triad in classical autism and provides new biological markers in the diagnostic workup of ASDs.

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