Role of Serotonin in Airway Patency: Physiological and Morphological Evidence for Serotoninergic Inputs to Laryngeal Inspiratory Motoneurons

Author(s):  
Hideho Arita ◽  
Masahiro Sakamoto
Author(s):  
Liane Stroebel

AbstractThis contribution focuses on the close link between perception and language. The analysis will extend beyond morphological evidence to include the role of submorphological relics. It will also raise the question of whether sensorimotor and submorphemic knowledge might have an impact on political discussion. In short, this paper seeks to tackle the question: How aware are we that words and sounds in general and in political discourse in particular are never ‘innocent’?


2006 ◽  
Vol 119 (17) ◽  
pp. 1495-1496 ◽  
Author(s):  
Zarogiannis Sotirios ◽  
Hatzoglou Chrissi ◽  
Gourgoulianis Konstantinos ◽  
Molyvdas Paschalis-Adam

1990 ◽  
Vol 69 (2) ◽  
pp. 700-709 ◽  
Author(s):  
S. W. Mifflin

To better understand the role of the arterial chemoreceptors in the regulation of upper airway patency at the level of the oropharynx, intracellular recordings were obtained from inspiratory hypoglossal motoneurons (IHMs), and the responses to selective activation of the carotid body chemoreceptors were examined. In pentobarbital-anesthetized, vagotomized, paralyzed, and artificially ventilated cats, chemoreceptor activation enhanced the inspiratory depolarization of membrane potential in 32 of 36 IHMs. This was manifested as an increase in either the amplitude (n = 13) or duration (n = 3) or an increase in both amplitude and duration (n = 16) of the inspiratory membrane potential depolarization. The amplitude and duration of the inspiratory membrane potential depolarization increased 98 +/- 15% (n = 29) and 78 +/- 13% (n = 19), respectively. Similar patterns of enhanced activity (increased duration and/or amplitude of membrane depolarization) were observed in five expiratory hypoglossal motoneurons (EHMs) after chemoreceptor activation. In 16 of the 32 IHMs, chemoreceptor activation also evoked changes in IHM membrane potential during expiration: enhanced post-inspiratory discharge (n = 6), expiratory depolarization/discharge (n = 6), and tonic depolarization/discharge, which persisted for several respiratory cycles (n = 4). The arterial chemoreceptors provide a powerful excitatory input to IHMs during both inspiration and expiration. This excitatory drive to IHMs and EHMs will aid in the maintenance of upper airway patency throughout the respiratory cycle during increases in end-tidal CO2.


2013 ◽  
Vol 10 (9) ◽  
pp. 6115-6130 ◽  
Author(s):  
M. Pacton ◽  
S. F. M. Breitenbach ◽  
F. A. Lechleitner ◽  
A. Vaks ◽  
C. Rollion-Bard ◽  
...  

Abstract. Calcitic speleothems in caves can form through abiogenic or biogenic processes, or through a combination of both. Many issues conspire to make the assessment of biogenicity difficult, especially when focusing on old speleothem deposits. This study reports on a multiproxy analysis of a Siberian stalactite, combining high-resolution microscopy, isotope geochemistry and microbially enhanced mineral precipitation laboratory experiments. The contact between growth layers in a stalactite exhibits a biogenic isotopic signature; coupled with morphological evidence, this supports a microbial origin of calcite crystals. SIMS δ13C data suggest that microbially mediated speleothem formation occurred repeatedly at short intervals before abiotic precipitation took over. The studied stalactite also contains iron and manganese oxides that have been mediated by microbial activity through extracellular polymeric substance (EPS)-influenced organomineralization processes. The latter reflect paleoenvironmental changes that occurred more than 500 000 yr ago, possibly related to the presence of a peat bog above the cave at that time. Microbial activity can initiate calcite deposition in the aphotic zone of caves before inorganic precipitation of speleothem carbonates. This study highlights the importance of microbially induced fractionation that can result in large negative δ13C excursions. The microscale biogeochemical processes imply that microbial activity has only negligible effects on the bulk δ13C signature in speleothems, which is more strongly affected by CO2 degassing and the host rock signature.


1994 ◽  
Vol 103 (3) ◽  
pp. 167-172 ◽  
Author(s):  
Kathleen C. Y. Sie ◽  
Trevor McGill ◽  
Gerald B. Healy

Patients with subglottic hemangioma present with biphasic stridor during infancy. The natural history of this lesion is characterized by progressive airway obstruction during the proliferative phase of the lesion, followed by resolution of symptoms during the subsequent involutive phase. Although this is a benign neoplasm, it can be associated with a fatal outcome. Treatment options have been directed at maintaining airway patency during the proliferative phase. The senior author (G.B.H.) originally described the role of the carbon dioxide laser in management of these patients in 1980. Thirty-one patients were treated for subglottic hemangioma at The Children's Hospital, Boston, between 1980 and 1990. The 10-year experience of management of subglottic hemangioma with endoscopic vaporization using the carbon dioxide laser is reviewed to assess the efficacy of this technique.


2020 ◽  
Vol 36 (01) ◽  
pp. 120-128
Author(s):  
Jason E. Cohn ◽  
Tom Shokri ◽  
Sammy Othman ◽  
Mofiyinfolu Sokoya ◽  
Yadranko Ducic

AbstractIn this systematic review we aim to (1) describe the anatomy and function of the soft tissue triangle, (2) identify the existing rhinoplasty literature that discusses the role of the soft tissue triangle, (3) provide a summary of the outcome measures for soft tissue triangle techniques in rhinoplasty, and (4) demonstrate the need for further research reviewing soft tissue triangle techniques in rhinoplasty. A systematic literature review was conducted from 2002 to 2019 utilizing MEDLINE/PubMed, Embase, Ovid, and Cochrane databases with the keywords, “rhinoplasty” and “soft tissue triangle” or “facet” to identify articles that describe the anatomical significance, clinical applicability, and rhinoplasty outcomes involving the soft tissue triangle. A total of 26 studies were identified as appropriate for inclusion. The vast majority describe the relationship of structure and function of the soft tissue triangle with particular focus on notching and retraction. The soft tissue triangle is an important area of the nose often neglected in rhinoplasty. This area is a common source of patient dissatisfaction and the need for revision rhinoplasty. Due to this fact, a formal evaluation of the role of the soft tissue triangle in nasal airway patency is needed. Specific validated outcome measures such as the NOSE (Nasal Obstruction and Septoplasty Effectiveness) score or the SCHNOS (Standardized Cosmesis and Health Nasal Outcomes Survey) should be employed in the evaluation of surgical intervention to the soft tissue triangle.


2020 ◽  
Vol 90 (1) ◽  
Author(s):  
Angelo Carretta ◽  
Paola Ciriaco ◽  
Alessandro Bandiera ◽  
Piergiorgio Muriana ◽  
Gianluigi Arrigoni ◽  
...  

Primary chondrosarcoma of the trachea is an extremely rare tumor. We report two cases of tracheal chondrosarcoma describing the role of surgical and conservative treatment. Endoscopic treatment with rigid bronchoscopy was performed in both patients to restore airway patency and obtain histological specimens for diagnosis. One of the patients subsequently underwent successful tracheal resection and reconstruction. The other patient, who had a contraindication to surgical treatment due to associated diseases underwent iterative endoscopic LASER treatment and is alive three years after the first diagnosis. Surgical treatment remains the treatment of choice of tracheal chondrosarcoma. When surgery is contraindicated endoscopic treatment may allow relatively longterm survival due to the slow growth of these tumors.


1992 ◽  
Vol 37 (3) ◽  
pp. 310
Author(s):  
T.J. Görcs ◽  
P.E. Gottschall ◽  
B.D. Shivers ◽  
G. Légrádi ◽  
J. Hámori ◽  
...  

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