Single Day Treatment — A Feasible Tool in Revealing Not Dependent on Maternal Toxicity Teratogenic Potential

SummaryHigh and low molecular weight heparin fractions obtained by gel filtration chromatography of sodium mucosal heparin were injected subcutaneously into six healthy volunteers and compared with the unfractionated substance in a cross-over trial. Equal doses of 5,000 U were administered twice daily over a period of three days and heparin activity was repeatedly controlled before and 2, 4, 8 hrs after injection by means of the APTT, the anti-Xa clotting test and a chromogenic substrate assay. In addition, the in vivo effect of subcutaneously administered fractionated heparin on platelet function was examined on three of the volunteers. The results show that s.c. injections of the low molecular weight fraction induced markedly higher anti-Xa activity than injections of the other preparations. At the same time, APTT results did not significantly differ. Unfractionated heparin and the high molecular weight fraction enhanced ADP-induced platelet aggregation and collagen-mediated MDA production, while the low molecular weight fraction hardly affected these assays, but potently inhibited thrombin-induced MDA production. All heparin preparations stimulated the release of platelet Factor 4 in plasma. During the three-day treatment periods, no side-effects and no significant changes in the response to heparin injections were detected.

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Induction of micronuclei and other nuclear abnormalities in blue mussels Mytilus edulis after 1-, 2-, 4- and 8-day treatment with crude oil from the North Sea

Ekologija ◽

10.2478/v10055-010-0018-4 ◽

2010 ◽

Vol 56 (3) ◽

pp. 124-131 ◽

Cited By ~ 11

Author(s):

Janina Baršienė ◽

Laura Andreikėnaitė ◽

Anne Bjornstad

Keyword(s):

Crude Oil ◽

Mytilus Edulis ◽

North Sea ◽

Day Treatment ◽

Nuclear Abnormalities ◽

Blue Mussels ◽

The North ◽

The North Sea

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STUDY ON THE EFFECT OF THE CATGUT-EMBEDDING METHOD COMBINING WITH HERBAL MEDICINE ON THE TREATMENT OF SCIATICA BY WIND-COLD-DAMP ARTHRALGIA

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.4_5.28 ◽

2014 ◽

pp. 206-215

Author(s):

Huu Tham Nguyen ◽

Thi Tan Nguyen

Keyword(s):

Herbal Medicine ◽

Traditional Medicine ◽

Clinical Characteristics ◽

Day Treatment ◽

Patient Treatment ◽

Control Group ◽

Controlled Trials ◽

Study Group ◽

Moderate Pain ◽

Embedding Method

Objectives: To investigate clinical characteristics of patients with sciatica in Traditional Medicine Hospital in Thua Thien Hue province; To evaluate the effectiveness of the catgut-embedding method combining with herbal medicine on the treatment of sciatica by wind-cold-damp arthralgia. Subjects and Methods: Patients diagnosed with sciatica by wind-cold-damp arthralgia in-patient treatment in Traditional Medicine Hospital in Thua Thien Hue province. Methods: Clinical and controlled trials, a survey of 72 patients, which were divided into 2 groups: The study group: 36 patients: receiving treatment by catgut-embedding and herbal medicine; The control group: 36 patients: only use herbal medicine. 28-day treatment period. Patients were assessed at admission (T0), after 14 days (T14), after 28 days of treatment (T28). Results: After 28 days of treatment: no severity both 2 groups. The study group fell to 8.3% moderate pain, mostly mild pain (91.7%); the control group was 44.4% moderate pain, mild 55.6%.The catgut-embedding method does not cause any side effects. Key words: catgut-embedding method, sciatica by wind-cold-damp arthralgia

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