Fluorine-18 Ligands for the in Vivo Study of the Beta Adrenergic Receptor in the Heart and Lung

1991 ◽  
pp. 91-95
Author(s):  
T. J. Tewson ◽  
B. M. Kinsey ◽  
R. Barber
Keyword(s):  
Adrenergic Receptor ◽  
In Vivo Study ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic

scholarly journals Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system

2017 ◽  
Vol 232 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Daniela Fernandois ◽  
Gonzalo Cruz ◽  
Eun Kyung Na ◽  
Hernán E Lara ◽  
Alfonso H Paredes
Keyword(s):  
Adrenergic Receptor ◽  
Follicular Development ◽  
Sympathetic Nerves ◽  
Female Rats ◽  
Reproductive Aging ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Primordial Follicles ◽  
Follicular Cyst

Previous work has demonstrated that the increase in the activity of sympathetic nerves, which occurs during the subfertility period in female rats, causes an increase in follicular cyst development and impairs follicular development. In addition, the increase in ovarian sympathetic activity of aged rats correlates with an increased expression of kisspeptin (KISS1) in the ovary. This increase in KISS1 could participate in the decrease in follicular development that occurs during the subfertility period. We aimed to determine whether the blockade of ovarian sympathetic tone prevents the increase in KISS1 expression during reproductive aging and improves follicular development. We performed 2 experiments in rats: (1) an in vivo blockade of beta-adrenergic receptor with propranolol (5.0 mg/kg) and (2) an ovarian surgical denervation to modulate the sympathetic system at these ages. We measured Kisspeptin and follicle-stimulating hormone receptor (FSHR) mRNA and protein levels by qRT-PCR and western blot and counted primordial, primary and secondary follicles at 8, 10 and 12 months of age. The results showed that ovarian KISS1 decreased but FSHR increased after both propranolol administration and the surgical denervation in rats of 8, 10 and 12 months of age. An increase in FSHR was related to an increase in the number of smaller secondary follicles and a decreased number of primordial follicles at 8, 10 and 12 months of age. These results suggest that intraovarian KISS1 is regulated by sympathetic nerves via a beta-adrenergic receptor and participates locally in ovarian follicular development in reproductive aging.

Therapeutic Implications of Beta-Adrenergic Receptor Pharmacodynamic Properties

2008 ◽  
Vol 3 (3) ◽  
pp. 174-184 ◽  
Author(s):  
Carlos Taira ◽  
Andrea Carranza ◽  
Marcos Mayer ◽  
Carla Di Verniero ◽  
Javier Opezzo ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Therapeutic Implications
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