Therapeutic Potential of Amnion Epithelial Cells for Diabetes

2014 ◽  
pp. 253-257
Author(s):  
Chika Koike ◽  
Motonori Okabe ◽  
Toshiko Yoshida ◽  
Toshio Nikaido
Keyword(s):  
Epithelial Cells ◽  
Therapeutic Potential ◽  
Amnion Epithelial Cells

scholarly journals Fucoxanthin Ameliorates Oxidative Stress and Airway Inflammation in Tracheal Epithelial Cells and Asthmatic Mice

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1311
Author(s):  
Shu-Ju Wu ◽  
Chian-Jiun Liou ◽  
Ya-Ling Chen ◽  
Shu-Chen Cheng ◽  
Wen-Chung Huang
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Airway Inflammation ◽  
Inflammatory Cytokines ◽  
Inflammatory Responses ◽  
Therapeutic Potential ◽  
Eosinophil Infiltration ◽  
Tracheal Epithelial Cells ◽  
Tracheal Epithelial ◽  
And Oxidative Stress

Fucoxanthin is isolated from brown algae and was previously reported to have multiple pharmacological effects, including anti-tumor and anti-obesity effects in mice. Fucoxanthin also decreases the levels of inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) of asthmatic mice. The purpose of the present study was to investigate the effects of fucoxanthin on the oxidative and inflammatory responses in inflammatory human tracheal epithelial BEAS-2B cells and attenuated airway hyperresponsiveness (AHR), airway inflammation, and oxidative stress in asthmatic mice. Fucoxanthin significantly decreased monocyte cell adherence to BEAS-2B cells. In addition, fucoxanthin inhibited the production of pro-inflammatory cytokines, eotaxin, and reactive oxygen species in BEAS-2B cells. Ovalbumin (OVA)-sensitized mice were treated by intraperitoneal injections of fucoxanthin (10 mg/kg or 30 mg/kg), which significantly alleviated AHR, goblet cell hyperplasia and eosinophil infiltration in the lungs, and decreased Th2 cytokine production in the BALF. Furthermore, fucoxanthin significantly increased glutathione and superoxide dismutase levels and reduced malondialdehyde (MDA) levels in the lungs of asthmatic mice. These data demonstrate that fucoxanthin attenuates inflammation and oxidative stress in inflammatory tracheal epithelial cells and improves the pathological changes related to asthma in mice. Thus, fucoxanthin has therapeutic potential for improving asthma.

scholarly journals Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hao Ding ◽  
Linda Xiaoyan Li ◽  
Peter C. Harris ◽  
Junwei Yang ◽  
Xiaogang Li
Keyword(s):  
Kidney Disease ◽  
Epithelial Cells ◽  
Polycystic Kidney Disease ◽  
Extracellular Vesicles ◽  
Autosomal Dominant ◽  
Therapeutic Potential ◽  
Polycystic Kidney ◽  
Renal Epithelial Cells ◽  
Autosomal Dominant Polycystic Kidney ◽  
Cyst Growth

AbstractAutosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal allele. However, if and how null ADPKD gene renal epithelial cells affect the biology and function of neighboring cells, including heterozygous renal epithelial cells, fibroblasts and macrophages during cyst initiation and expansion remains unknown. Here we address this question with a “cystic extracellular vesicles/exosomes theory”. We show that cystic cell derived extracellular vesicles and urinary exosomes derived from ADPKD patients promote cyst growth in Pkd1 mutant kidneys and in 3D cultures. This is achieved by: 1) downregulation of Pkd1 gene expression and upregulation of specific miRNAs, resulting in the activation of PKD associated signaling pathways in recipient renal epithelial cells and tissues; 2) the activation of fibroblasts; and 3) the induction of cytokine expression and the recruitment of macrophages to increase renal inflammation in cystic kidneys. Inhibition of exosome biogenesis/release with GW4869 significantly delays cyst growth in aggressive and milder ADPKD mouse models, suggesting that targeting exosome secretion has therapeutic potential for ADPKD.

scholarly journals Interleukin 4 Production by Human Amnion Epithelial Cells and Regulation of its Activity by Glycosaminoglycan Binding1

1995 ◽  
Vol 52 (4) ◽  
pp. 839-847 ◽  
Author(s):  
Catherine A. Jones ◽  
Keryn A. Williams ◽  
John J. Finlay-Jones ◽  
Prue H. Hart
Keyword(s):  
Epithelial Cells ◽  
Interleukin 4 ◽  
Human Amnion ◽  
Amnion Epithelial Cells

scholarly journals Transplantation of Human Amnion Epithelial Cells Reduces Hepatic Fibrosis in Immunocompetent CCl4-Treated Mice

2010 ◽  
Vol 19 (9) ◽  
pp. 1157-1168 ◽  
Author(s):  
Ursula Manuelpillai ◽  
Jorge Tchongue ◽  
Dinushka Lourensz ◽  
Vijesh Vaghjiani ◽  
Chrishan S. Samuel ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Hepatic Fibrosis ◽  
Human Amnion ◽  
Amnion Epithelial Cells

Amnion Epithelial Cells, in Contrast to Trophoblast Cells, Express All Classical HLA Class I Molecules Together With HLA-G

1997 ◽  
Vol 37 (2) ◽  
pp. 161-171 ◽  
Author(s):  
Astrid Hammer ◽  
Heinz Hutter ◽  
Astrid Blaschitz ◽  
Wolfgang Mahnert ◽  
Michaele Hartmann ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Hla Class I ◽  
Class I ◽  
Trophoblast Cells ◽  
Hla Class I Molecules ◽  
Amnion Epithelial Cells

A Comparison of Mesenchymal Precursor Cells and Amnion Epithelial Cells for Enhancing Cervical Interbody Fusion in an Ovine Model

Neurosurgery ◽  
2011 ◽  
Vol 68 (4) ◽  
pp. 1025-1035 ◽  
Author(s):  
Tony Goldschlager ◽  
Peter Ghosh ◽  
Andrew Zannettino ◽  
Mark Williamson ◽  
Jeffrey Victor Rosenfeld ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Interbody Fusion ◽  
Precursor Cells ◽  
Ovine Model ◽  
Mesenchymal Precursor Cells ◽  
Mesenchymal Precursor ◽  
Amnion Epithelial Cells

scholarly journals A distinct mechanism of senescence activation in amnion epithelial cells by infection, inflammation, and oxidative stress

2017 ◽  
Vol 79 (3) ◽  
pp. e12790 ◽  
Author(s):  
Christopher Luke Dixon ◽  
Lauren Richardson ◽  
Samantha Sheller-Miller ◽  
George Saade ◽  
Ramkumar Menon
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Distinct Mechanism ◽  
And Oxidative Stress ◽  
Amnion Epithelial Cells

scholarly journals Effect of Human Amnion Epithelial Cells on the Acute Inflammatory Response in Fetal Sheep

2017 ◽  
Vol 8 ◽  
Author(s):  
Alana Westover ◽  
Jacqueline M. Melville ◽  
Courtney McDonald ◽  
Rebecca Lim ◽  
Graham Jenkin ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
Fetal Sheep ◽  
Human Amnion ◽  
Amnion Epithelial Cells
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