Substituted Pyridoindoles as Biological Antioxidants: Drug Design, Chemical Synthesis, and Biological Activity

2014 ◽  
pp. 313-327 ◽  
Author(s):  
Lucia Kovacikova ◽  
Magdalena Majekova ◽  
Milan Stefek
Keyword(s):  
Biological Activity ◽  
Drug Design ◽  
Chemical Synthesis

Synthesis and Biological Activity Study of Tanshinone Derivatives: A Literature and Patent Review

2020 ◽  
Vol 20 (28) ◽  
pp. 2520-2534
Author(s):  
He Huang ◽  
Chuanjun Song ◽  
Junbiao Chang
Keyword(s):  
Biological Activity ◽  
Herbal Medicine ◽  
Chemical Synthesis ◽  
Bioactive Compounds ◽  
Chinese Herbal Medicine ◽  
Salvia Miltiorrhiza ◽  
Salvia Miltiorrhiza Bunge ◽  
Chinese Herbal ◽  
Patent Review

: Tanshinones are a class of bioactive compounds present in the Chinese herbal medicine Danshen (Salvia miltiorrhiza Bunge), containing among others, abietane diterpene quinone scaffolds. Chemical synthesis and biological activity studies of natural and unnatural tanshinone derivatives have been reviewed in this article.

scholarly journals Enantioselective Catalytic C-H Amidations: An Highlight

Catalysts ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 471
Author(s):  
Eleonora Tosi ◽  
Renata Marcia de Figueiredo ◽  
Jean-Marc Campagne
Keyword(s):  
Biological Activity ◽  
Chemical Synthesis ◽  
Crucial Role ◽  
Medicinal Chemistry ◽  
Life Sciences ◽  
Biological Processes ◽  
Chiral Molecules ◽  
Material Sciences ◽  
Innovative Approaches

The crucial role played by compounds bearing amide functions, not only in biological processes but also in several fields of chemistry, life polymers and material sciences, has brought about many significant discoveries and innovative approaches for their chemical synthesis. Indeed, a plethora of strategies has been developed to reach such moieties. Amides within chiral molecules are often associated with biological activity especially in life sciences and medicinal chemistry. In most of these cases, their synthesis requires extensive rethinking methodologies. In the very last years (2019–2020), enantioselective C-H functionalization has appeared as a straightforward alternative to reach chiral amides. Therein, an overview on these transformations within this timeframe is going to be given.

scholarly journals Cordycepin analogues of 2-5A and its derivatives. Chemical synthesis and biological activity.

1983 ◽  
Vol 258 (3) ◽  
pp. 1671-1677
Author(s):  
H Sawai ◽  
J Imai ◽  
K Lesiak ◽  
M I Johnston ◽  
P F Torrence
Keyword(s):  
Biological Activity ◽  
Chemical Synthesis

Chemical Synthesis, Structural Modeling, and Biological Activity of the Epidermal Growth Factor-like Domain of HumanCripto

Biochemistry ◽  
1997 ◽  
Vol 36 (13) ◽  
pp. 3837-3845 ◽  
Author(s):  
Matthias Lohmeyer ◽  
Paul M. Harrison ◽  
Subha Kannan ◽  
Marta DeSantis ◽  
Nicola J. O'Reilly ◽  
...  
Keyword(s):  
Biological Activity ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chemical Synthesis ◽  
Structural Modeling ◽  
Epidermal Growth

Biological Activity, Physical Properties, and Toxicity

2021 ◽  
Vol 6 (3) ◽  
pp. 25-34
Author(s):  
Ranita Pal ◽  
Pratim Kumar Chattaraj
Keyword(s):  
Molecular Structure ◽  
Biological Activity ◽  
Molecular Biology ◽  
Drug Design ◽  
Physical Properties ◽  
Quantitative Structure Activity Relationship ◽  
Molecular Properties ◽  
Quantitative Structure ◽  
Qsar Analysis ◽  
Structure Activity

In the current pandemic-stricken world, quantitative structure-activity relationship (QSAR) analysis has become a necessity in the domain of molecular biology and drug design, realizing that it helps estimate properties and activities of a compound, without actually having to spend time and resources to synthesize it in the laboratory. Correlating the molecular structure of a compound with its activity depends on the choice of the descriptors, which becomes a difficult and confusing task when we have so many to choose from. In this mini-review, the authors delineate the importance of very simple and easy to compute descriptors in estimating various molecular properties/toxicity.

Chemical synthesis and biological activity of 3-deoxy-1α-hydroxyvitamin D3 an analog of 1α,25-(OH)2-D3, the active form of vitamin D3

1974 ◽  
Vol 60 (1) ◽  
pp. 179-185 ◽  
Author(s):  
William H. Okamura ◽  
Manindra N. Mitra ◽  
Richard M. Wing ◽  
Anthony W. Norman
Keyword(s):  
Biological Activity ◽  
Chemical Synthesis ◽  
Vitamin D3 ◽  
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