Assessment of Anti-donor T Cell Proliferation and Cytotoxic T Lymphocyte-Mediated Lympholysis in Living Donor Kidney Transplant Patients

2014 ◽  
pp. 355-364 ◽  
Author(s):  
Aruna Rakha ◽  
Marta Todeschini ◽  
Federica Casiraghi
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Kidney Transplant ◽  
T Lymphocyte ◽  
Living Donor ◽  
Cytotoxic T Lymphocyte ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Living Donor Kidney Transplant ◽  
Living Donor Kidney

MP06-02 SERUM SIALYL HYBRID TYPED N -GLYCAN LEVELS PREDICTS EARLY ABMR IN LIVING DONOR KIDNEY TRANSPLANT PATIENTS

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Daisuke Noro ◽  
Tohru Yoneyama ◽  
Shingo Hatakeyama ◽  
Yuki Tobisawa ◽  
Kazuyuki Mori ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Living Donor ◽  
Donor Kidney ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Living Donor Kidney Transplant ◽  
Living Donor Kidney

Calcineurin Inhibitor Withdrawal in Stable Kidney Transplant Patients Decreases the Donor-Specific Cytotoxic T Lymphocyte Precursor Frequency

2005 ◽  
Vol 80 (9) ◽  
pp. 1220-1225 ◽  
Author(s):  
Barbara J. van der Mast ◽  
Jacqueline Rischen-Vos ◽  
Petronella de Kuiper ◽  
Lenard M. B. Vaessen ◽  
Nicole M. van Besouw ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
T Lymphocyte ◽  
Calcineurin Inhibitor ◽  
Cytotoxic T Lymphocyte ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Precursor Frequency

scholarly journals Invariance of measures to understand decision-making for pursuing living donor kidney transplant

2016 ◽  
Vol 21 (12) ◽  
pp. 2912-2922 ◽  
Author(s):  
Leslie Ann Brick ◽  
Donya Sorensen ◽  
Mark L Robbins ◽  
Andrea L Paiva ◽  
John D Peipert ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Self Efficacy ◽  
Living Donor ◽  
Decisional Balance ◽  
Education Level ◽  
Donor Kidney ◽  
Sequential Approach ◽  
Demographic Subgroups ◽  
Living Donor Kidney Transplant ◽  
Living Donor Kidney

Living donor kidney transplant is the ideal treatment option for end-stage renal disease; however, the decision to pursue living donor kidney transplant is complex and challenging. Measurement invariance of living donor kidney transplant Decisional Balance and Self-Efficacy across gender (male/female), race (Black/White), and education level (no college/college or higher) were examined using a sequential approach. Full strict invariance was found for Decisional Balance and Self-Efficacy for gender and partial strict invariance was found for Decisional Balance and Self-Efficacy across race and education level. This information will inform tailored feedback based on these constructs in future intervention studies targeting behavior change among specific demographic subgroups.

scholarly journals Comparison of humoral and cellular responses in kidney transplant recipients receiving BNT162b2 and ChAdOx1 SARS-CoV-2 vaccines

2021 ◽  
Author(s):  
Maria Prendecki ◽  
Tina Thomson ◽  
Candice L Clarke ◽  
Paul Martin ◽  
Sarah Gleeson ◽  
...  
Keyword(s):  
T Cell ◽  
Kidney Transplant ◽  
T Cell Responses ◽  
Cellular Responses ◽  
Control Group ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Cell Responses ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Background Attenuated immune responses to mRNA SARS-CoV-2 vaccines have been reported in solid organ transplant recipients. Most studies have assessed serological responses alone, and there is limited immunological data on vector-based vaccines in this population. This study compares the immunogenicity of BNT162b2 with ChAdOx1 in kidney transplant patients, assessing both serological and cellular responses. Methods 920 patients were screened for spike protein antibodies (anti-S) following 2 doses of either BNT162b2 (n=490) or ChAdOx1 (n=430). 106 patients underwent assessment with T-cell ELISpot assays. 65 health care workers were used as a control group. Results Anti-S was detected in 569 (61.8%) patients. Seroconversion rates in infection-naïve patients who received BNT162b2 were higher compared with ChAdOx1, at 269/410 (65.6%) and 156/358 (43.6%) respectively, p<0.0001. Anti-S concentrations were higher following BNT162b, 58(7.1-722) BAU/ml, compared with ChAdOx1, 7.1(7.1-39) BAU/ml, p<0.0001. Calcineurin inhibitor monotherapy, vaccination occurring >1st year post-transplant and receiving BNT162b2 was associated with seroconversion. Only 28/106 (26.4%) of patients had detectable T-cell responses. There was no difference in detection between infection-naïve patients who received BNT162b2, 7/40 (17.5%), versus ChAdOx1, 2/39 (5.1%), p=0.15. There was also no difference in patients with prior infection who received BNT162b2, 8/11 (72.7%), compared with ChAdOx1, 11/16 (68.8%), p=0.83. Conclusions. Enhanced humoral responses were seen with BNT162b2 compared with ChAdOx1 in kidney transplant patients. T-cell responses to both vaccines were markedly attenuated. Clinical efficacy data is still required but immunogenicity data suggests weakened responses to both vaccines in transplant patients, with ChAdOx1 less immunogenic compared with BNT162b2.

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