Site-Specific Delivery of Epigenetic Modulating Drugs into the Rat Brain

2016 ◽  
pp. 149-159
Author(s):  
Amanda Sales ◽  
Caroline Biojone ◽  
Sâmia Joca
Keyword(s):  
Rat Brain ◽  
Site Specific

Corticosterone receptors decline in a site-specific manner in the aged rat brain

1983 ◽  
Vol 289 (1-2) ◽  
pp. 235-240 ◽  
Author(s):  
Robert M. Sapolsky ◽  
Lewis C. Krey ◽  
Bruce S. McEwen
Keyword(s):  
Rat Brain ◽  
Site Specific ◽  
Aged Rat ◽  
Specific Manner ◽  
A Site

scholarly journals Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain

1999 ◽  
Vol 19 (14) ◽  
pp. 5990-6005 ◽  
Author(s):  
Rosemary A. Fricker ◽  
Melissa K. Carpenter ◽  
Christian Winkler ◽  
Corinne Greco ◽  
Monte A. Gates ◽  
...  
Keyword(s):  
Rat Brain ◽  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Site Specific ◽  
Adult Rat ◽  
Adult Rat Brain ◽  
Human Neural Progenitor Cells

Thyroid hormone exerts site-specific effects on SRC-1 and NCoR expression selectively in the neonatal rat brain

2002 ◽  
Vol 186 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Eric A Iannacone ◽  
Arthur W Yan ◽  
Kelly J Gauger ◽  
Amy L.S Dowling ◽  
R.Thomas Zoeller
Keyword(s):  
Thyroid Hormone ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Site Specific ◽  
Specific Effects ◽  
Neonatal Rat Brain

Large-cluster and combined fluorescent and gold immunoprobes

1996 ◽  
Vol 54 ◽  
pp. 892-893
Author(s):  
Richard D. Powell ◽  
James F. Hainfeld ◽  
Carol M. R. Halsey ◽  
David L. Spector ◽  
Shelley Kaurin ◽  
...  
Keyword(s):  
Metal Cluster ◽  
Sulfonyl Chloride ◽  
Gel Filtration ◽  
Cross Linking ◽  
Site Specific ◽  
Fab Fragments ◽  
Cluster Label ◽  
Covalently Linked ◽  
Texas Red ◽  
Fold Excess

Two new types of covalently linked, site-specific immunoprobes have been prepared using metal cluster labels, and used to stain components of cells. Combined fluorescein and 1.4 nm “Nanogold” labels were prepared by using the fluorescein-conjugated tris (aryl) phosphine ligand and the amino-substituted ligand in the synthesis of the Nanogold cluster. This cluster label was activated by reaction with a 60-fold excess of (sulfo-Succinimidyl-4-N-maleiniido-cyclohexane-l-carboxylate (sulfo-SMCC) at pH 7.5, separated from excess cross-linking reagent by gel filtration, and mixed in ten-fold excess with Goat Fab’ fragments against mouse IgG (obtained by reduction of F(ab’)2 fragments with 50 mM mercaptoethylamine hydrochloride). Labeled Fab’ fragments were isolated by gel filtration HPLC (Superose-12, Pharmacia). A combined Nanogold and Texas Red label was also prepared, using a Nanogold cluster derivatized with both and its protected analog: the cluster was reacted with an eight-fold excess of Texas Red sulfonyl chloride at pH 9.0, separated from excess Texas Red by gel filtration, then deprotected with HC1 in methanol to yield the amino-substituted label.

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