Thyroid hormone exerts site-specific effects on SRC-1 and NCoR expression selectively in the neonatal rat brain

2002 ◽  
Vol 186 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Eric A Iannacone ◽  
Arthur W Yan ◽  
Kelly J Gauger ◽  
Amy L.S Dowling ◽  
R.Thomas Zoeller
Keyword(s):  
Thyroid Hormone ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Site Specific ◽  
Specific Effects ◽  
Neonatal Rat Brain

Characteristics of rT3 5'-monodeiodination in rat brain: comparison with T4 and T3 5-monodeiodinations

1982 ◽  
Vol 101 (3) ◽  
pp. 371-376 ◽  
Author(s):  
Kiyoshi Tanaka ◽  
Mitsuo Inada ◽  
Yasuo Mashio ◽  
Hitoshi Ishii ◽  
Koichi Naito ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Thyroid Hormone ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Deiodinase Activity ◽  
The Central Nervous System ◽  
Enzymatic Nature ◽  
Neonatal Rat Brain ◽  
Optimal Ph

Abstract. The present study revealed the existence and some characteristics of rT3 5'-deiodinase in rat brain by measuring the production of 3,3'-T2 from rT3 by radioimmunoassay. The conversion of rT3 to 3,3'-T2 was dependent on the duration of the incubation, tissue amount, temperature and pH (the optimal pH was 8.0), suggesting its enzymatic nature. Apparent Km was estimated to be 0.16 μm and the Vmax was 139.3 fmol/mg protein/min. The converting activity was dependent on the concentration of dithiothreitol (DTT). In contrast to T4 or T3 5-deiodinase, rT3 5'-deiodinase activity in the rat brain was the highest in cerebellum and the activity was low in the neonatal rat brain. Moreover, the 5'-deiodinase activity was inhibited by propylthiouracil (PTU). These differences between rT3 5'-deiodinase and T4 or T3 5-deiodinase suggest that different deiodinases are present in rat brain, and that local conversion of thyroid hormone is important for its action in the central nervous system.

scholarly journals The Thyroid Hormone-Regulated Corepressor Hairless Associates with Histone Deacetylases in Neonatal Rat Brain

2002 ◽  
Vol 16 (11) ◽  
pp. 2547-2560 ◽  
Author(s):  
Gregory B. Potter ◽  
Joanna M. Zarach ◽  
Jeanne M. Sisk ◽  
Catherine C. Thompson
Keyword(s):  
Thyroid Hormone ◽  
Rat Brain ◽  
Histone Deacetylases ◽  
Neonatal Rat ◽  
Neonatal Rat Brain

In vivo diffusion tensor imaging of the neonatal rat brain development

2013 ◽  
Vol 44 (S 01) ◽  
Author(s):  
M Breu ◽  
D Reisinger ◽  
D Wu ◽  
Y Zhang ◽  
A Fatemi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Brain Development ◽  
Rat Brain ◽  
Diffusion Tensor ◽  
Neonatal Rat ◽  
Neonatal Rat Brain

Resveratrol ameliorates hypoxia/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain

2011 ◽  
Vol 1425 ◽  
pp. 98-110 ◽  
Author(s):  
Filippos Karalis ◽  
Vassiliki Soubasi ◽  
Thomas Georgiou ◽  
Christos T. Nakas ◽  
Constantina Simeonidou ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Behavioral Deficits ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Brain
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