Thyroid Nodules in Children and Cancer Risk

2016 ◽  
pp. 335-346
Author(s):  
Andrew J. Bauer
Keyword(s):  
Cancer Risk ◽  
Thyroid Nodules

Cancer risk and clinicopathological characteristics of thyroid nodules harboring thyroid-stimulating hormone receptor gene mutations

2018 ◽  
Vol 46 (5) ◽  
pp. 369-377 ◽  
Author(s):  
Sann Y. Mon ◽  
Gregory Riedlinger ◽  
Collette E. Abbott ◽  
Raja Seethala ◽  
N. Paul Ohori ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Hormone Receptor ◽  
Thyroid Nodules ◽  
Receptor Gene ◽  
Gene Mutations ◽  
Clinicopathological Characteristics ◽  
Thyroid Stimulating Hormone ◽  
Hormone Receptor Gene ◽  
Stimulating Hormone

Serum osteopontin can improve papillary thyroid cancer risk assessment of Bethesda III thyroid nodules: a preliminary study

2021 ◽  
Author(s):  
Taha Ulutan Kars ◽  
Mustafa Kulaksizoglu ◽  
İbrahim Kılınç
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Papillary Thyroid Cancer ◽  
Thyroid Nodules ◽  
Cancer Risk Assessment ◽  
Papillary Thyroid ◽  
Operating Characteristics ◽  
Discriminative Performance ◽  
Thyroid Cancer Risk ◽  
Preliminary Study

Objective: Thyroid cancer can be detected in 5–10% of patients with thyroid nodules. Management may be a challenge if fine-needle aspiration biopsy yields Bethesda III findings. Most of these cases undergo surgery and are ultimately found benign. Our aim was to evaluate whether serum osteopontin can accurately estimate thyroid cancer risk in cases with cytologically Bethesda III thyroid nodules and, thereby, decrease the number of unnecessary surgical interventions. Design and Methods: We obtained blood samples of cases with repeated cytologically Bethesda III thyroid nodules before surgery, and followed up the pathology results after thyroidectomy. We evaluated serum osteopontin from 36 patients with papillary thyroid cancer and compared them with 40 benign cases. Results: Serum osteopontin levels in patients with papillary thyroid cancer are significantly higher than in benign cases (mean serum osteopontin: 10.48 ± 3.51 ng/mL vs 6.14 ± 2.29 ng/mL, p<0.001). The area under the receiver operating characteristics curve was 0.851, suggesting that serum osteopontin could have considerable discriminative performance. Conclusions: In our preliminary study, high serum osteopontin levels can predict the risk of papillary thyroid cancer in thyroid nodules with Bethesda III cytology. Further studies are necessary to confirm these findings.

scholarly journals Thyroid Nodules with Indeterminate Cytology: Utility of the American Thyroid Association Sonographic Patterns for Cancer Risk Stratification

Thyroid ◽  
2018 ◽  
Vol 28 (8) ◽  
pp. 1004-1012 ◽  
Author(s):  
Pablo Valderrabano ◽  
Melissa J. McGettigan ◽  
Cesar A. Lam ◽  
Laila Khazai ◽  
Zachary J. Thompson ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Risk Stratification ◽  
Thyroid Nodules ◽  
American Thyroid Association ◽  
Sonographic Patterns ◽  
Indeterminate Cytology

Retrospective Analysis of Thyroid Nodules: Thyroid Cancer Risk Factors in Suzhou, China

2018 ◽  
Vol 64 (03/2018) ◽  
Author(s):  
Chenlu Zhu ◽  
Shuxiang Li ◽  
Xin Gao ◽  
Gengchao Zhu ◽  
Miaoli Song ◽  
...  
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Retrospective Analysis ◽  
Thyroid Nodules ◽  
Cancer Risk Factors ◽  
Thyroid Cancer Risk

scholarly journals Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis

Thyroid ◽  
2018 ◽  
Vol 28 (2) ◽  
pp. 210-219 ◽  
Author(s):  
Pablo Valderrabano ◽  
Laila Khazai ◽  
Zachary J. Thompson ◽  
Susan C. Sharpe ◽  
Valentina D. Tarasova ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Risk ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Nuclear Atypia

scholarly journals Approach to the Patient with a Cytologically Indeterminate Thyroid Nodule

2008 ◽  
Vol 93 (11) ◽  
pp. 4175-4182 ◽  
Author(s):  
Erik K. Alexander
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Nodule ◽  
Surgical Procedures ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Follicular Neoplasm ◽  
Fine Needle ◽  
Thyroid Cancer Risk

Background: Fine-needle aspiration remains the primary diagnostic intervention for the evaluation of most thyroid nodules larger than 1–1.5 cm. Although most aspirates provide diagnostic cytology, approximately 15–25% will be classified indeterminate (often referred to as follicular neoplasm, suspicious for carcinoma, or atypical). In such cases, abnormal cellular findings preclude interpretation of benignity, although only a minority will prove cancerous upon final histopathology. Nonetheless, patients with indeterminate aspirates are commonly referred for consideration of hemi- or near-total thyroidectomy. Recently, improved understanding and novel investigation of clinical, radiological, cytological, and molecular factors has allowed improved stratification of cancer risk. Conclusion: Although surgery continues to be commonly recommended, strategies for such patients should increasingly seek to define treatment based on the estimation of an individual’s thyroid cancer risk in comparison with associated operative risk and morbidity. In doing so, the rate of unnecessary surgical procedures and associated complications can be reduced.

scholarly journals Increased Cancer Risk in Younger Patients with Thyroid Nodules Diagnosed as Atypia of Undetermined Significance

Cureus ◽  
2018 ◽  
Author(s):  
Emilija Todorovic ◽  
Brandon S Sheffield ◽  
Steve Kalloger ◽  
Blair Walker ◽  
Sam M Wiseman
Keyword(s):  
Cancer Risk ◽  
Thyroid Nodules ◽  
Younger Patients ◽  
Undetermined Significance

Cancer risk in patients with cold thyroid nodules: Relevance of iodine intake, sex, age, and multinodularity

1992 ◽  
Vol 93 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Antonino Belfiore ◽  
Giacomo Lucio La Rosa ◽  
Gianfranco Antonio La Porta ◽  
Dario Giuffrida ◽  
Giovanni Milazzo ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Thyroid Nodules ◽  
Iodine Intake ◽  
Cold Thyroid Nodules

Thyroglobulin Antibody Is Associated with Increased Cancer Risk in Thyroid Nodules.

2010 ◽  
pp. P1-555-P1-555
Author(s):  
KH Baek ◽  
ES Kim ◽  
DJ Lim ◽  
MI Kang ◽  
KW Lee
Keyword(s):  
Cancer Risk ◽  
Thyroid Nodules ◽  
Thyroglobulin Antibody

Combined Molecular and Histologic Endpoints Inform Cancer Risk Estimates for Thyroid Nodules Classified as Atypia of Undetermined Significance

2021 ◽  
Vol 10 (5) ◽  
pp. S52-S53
Author(s):  
Allison Onken ◽  
Paul VanderLaan ◽  
James Hennessey ◽  
Pamela Hartzband ◽  
Michiya Nishino
Keyword(s):  
Cancer Risk ◽  
Thyroid Nodules ◽  
Risk Estimates ◽  
Undetermined Significance
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