In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin

2016 ◽  
pp. 55-68 ◽  
Author(s):  
Romi Ghose ◽  
Pankajini Mallick ◽  
Guncha Taneja ◽  
Chun Chu ◽  
Bhagavatula Moorthy
Keyword(s):  
Cytochrome P450 ◽  
Approaches To Study ◽  
Cyp 3A ◽  
Hepatic Cytochrome

Mechanism-based inhibition of Alantolactone on human cytochrome P450 3A4 in vitro and activity of hepatic cytochrome P450 in mice

2015 ◽  
Vol 168 ◽  
pp. 146-149 ◽  
Author(s):  
Chong-Zhen Qin ◽  
Qiao-Li Lv ◽  
Na-Yiyuan Wu ◽  
Lin Cheng ◽  
Yun-Chen Chu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 3A4 ◽  
Human Cytochrome ◽  
Hepatic Cytochrome

scholarly journals beta-Naphthoflavone abolishes interrenal sensitivity to ACTH stimulation in rainbow trout

1998 ◽  
Vol 157 (1) ◽  
pp. 63-70 ◽  
Author(s):  
JM Wilson ◽  
MM Vijayan ◽  
CJ Kennedy ◽  
GK Iwama ◽  
TW Moon
Keyword(s):  
Cytochrome P450 ◽  
Rainbow Trout ◽  
Acth Stimulation ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Treated Fish ◽  
First Time ◽  
Hepatic Cytochrome ◽  
Stimulation Of

We report for the first time that beta-naphthoflavone (BNF) abolishes ACTH stimulation of cortisol production in rainbow trout (Oncorhynchus mykiss). There was significantly higher hepatic cytochrome P450 content and ethoxyresorufin O-de-ethylase and uridine-5'-diphosphoglucuronic acid transferase activities in BNF-treated fish than in sham-treated controls. BNF did not significantly affect either plasma turnover or tissue distribution of [3H]cortisol-derived radioactivity. Hepatic membrane fluidity and hepatocyte capacity for cortisol uptake were not altered by BNF as compared with the sham-treated fish. These results taken together suggest that BNF does not affect cortisol-clearance mechanisms in trout. A 3 min handling disturbance period elicited a plasma cortisol response in the sham-treated fish; however, the response in the BNF-treated fish was muted and significantly lower than in the sham fish. This in vivo response corroborates the lack of interrenal sensitivity to ACTH in vitro in the BNF-treated fish, suggesting that BNF affects the ACTH pathway in trout. Our results suggest the possibility that cytochrome P450-inducing compounds may affect cortisol dynamics by decreasing interrenal responsiveness to ACTH stimulation in fish, thereby impairing the physiological responses that are necessary for the animal to cope with the stressor.

In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle

1999 ◽  
Vol 66 (1) ◽  
pp. 51-55 ◽  
Author(s):  
W.M ZWEERS-ZEILMAKER ◽  
A.S.J.P.A.M VAN MIERT ◽  
G.J HORBACH ◽  
R.F WITKAMP
Keyword(s):  
Cytochrome P450 ◽  
Complex Formation ◽  
Cytochrome P450 Activity ◽  
P450 Activity ◽  
Hepatic Cytochrome

In Vitro and In Vivo Evaluation of the Effect of Puerarin on Hepatic Cytochrome P450-Mediated Drug Metabolism

Planta Medica ◽  
2014 ◽  
Vol 80 (07) ◽  
pp. 561-567 ◽  
Author(s):  
Sang-Bum Kim ◽  
In-Soo Yoon ◽  
Kyu-Sang Kim ◽  
Sung-Jun Cho ◽  
Yeong Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
In Vivo Evaluation ◽  
Hepatic Cytochrome

In Vitro and in Silico Analyses for Predicting Hepatic Cytochrome P450-Dependent Metabolic Potencies of Polychlorinated Biphenyls in the Baikal Seal

2015 ◽  
Vol 49 (24) ◽  
pp. 14588-14596 ◽  
Author(s):  
Jean Yoo ◽  
Masashi Hirano ◽  
Hazuki Mizukawa ◽  
Kei Nomiyama ◽  
Tetsuro Agusa ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Polychlorinated Biphenyls ◽  
In Silico ◽  
In Silico Analyses ◽  
Hepatic Cytochrome

scholarly journals Evaluation of the HC-04 Cell Line as an In Vitro Model for Mechanistic Assessment of Changes in Hepatic Cytochrome P450 3A during Adenovirus Infection

2014 ◽  
Vol 42 (7) ◽  
pp. 1191-1201 ◽  
Author(s):  
Piyanuch Wonganan ◽  
Kristina Jonsson-Schmunk ◽  
Shellie M. Callahan ◽  
Jin Huk Choi ◽  
Maria A. Croyle
Keyword(s):  
Cytochrome P450 ◽  
Cell Line ◽  
In Vitro Model ◽  
Adenovirus Infection ◽  
Cytochrome P450 3A ◽  
Vitro Model ◽  
Hepatic Cytochrome
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