Assessment of Functional Norovirus Antibody Responses by Blocking Assay in Mice

Author(s):  
Maria Malm ◽  
Kirsi Tamminen ◽  
Vesna Blazevic
2011 ◽  
Vol 19 (2) ◽  
pp. 284-287 ◽  
Author(s):  
Rita Czakó ◽  
Robert L. Atmar ◽  
Antone R. Opekun ◽  
Mark A. Gilger ◽  
David Y. Graham ◽  
...  

ABSTRACTA hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV (n= 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test,P= 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.


1991 ◽  
Author(s):  
R. R. Vickers ◽  
L. K. Hervig ◽  
Ruth Rappaport ◽  
Paul Linard

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