Applications of Mass Spectrometry in Drug Development Science

2016 ◽  
pp. 253-289
Author(s):  
Ulrike Leurs ◽  
Ulrik H. Mistarz ◽  
Kasper D. Rand
Keyword(s):  
Mass Spectrometry ◽  
Drug Development

Organ Perfusion and Mass Spectrometry: A Timely Merger for Drug Development

2002 ◽  
Vol 2 (1) ◽  
pp. 77-86 ◽  
Author(s):  
C. Curtis ◽  
Ben Chien ◽  
David Bar-Or ◽  
Kumar Ramu
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Organ Perfusion

scholarly journals A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL Anthelia sp.

2013 ◽  
Vol 13 (3) ◽  
pp. 216-220 ◽  
Author(s):  
Anggia Murni ◽  
Novriyandi Hanif ◽  
Junichi Tanaka
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Ethyl Acetate ◽  
Spectroscopic Data ◽  
Soft Coral ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Cancer Drug ◽  
Nmr Data ◽  
Anti Cancer

One new dolabellane (1) and two known diterpenoids stolonidiol (2) and clavinflol B (3) have been isolated from the ethyl acetate extract of the Indonesian soft coral Anthelia sp. A new compound 1 exhibited a moderate cytotoxicity against NBT-T2 cells at 10 µg/mL, while known compounds 2 and 3 showed cytotoxicity at 1 and 0.5 µg/mL, respectively. Structure of the new compound 1 was elucidated by interpretation of NMR spectroscopic data (1D and 2D NMR data) and mass spectrometry (ESIMS data) as well as comparison with those of related ones. This finding should be useful for anti cancer drug development of the promising dolabellane-types compound.

scholarly journals Imaging mass spectrometry in drug development and toxicology

2016 ◽  
Vol 91 (6) ◽  
pp. 2283-2294 ◽  
Author(s):  
Oskar Karlsson ◽  
Jörg Hanrieder
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Imaging Mass Spectrometry

Mass Spectrometry of Antibody–Drug Conjugates in Plasma and Tissue in Drug Development

2013 ◽  
pp. 279-304 ◽  
Author(s):  
Surinder Kaur ◽  
Keyang Xu ◽  
Ola Saad ◽  
Luna Liu ◽  
Tim Slattery ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Trends of State of the Art Technologies on New Drug Development using Accelerator Mass Spectrometry

Yakhak Hoeji ◽  
2016 ◽  
Vol 60 (4) ◽  
pp. 163-172
Author(s):  
Seok Ho Shin ◽  
◽  
Min Ho Park ◽  
Ye Ran Hwang ◽  
◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Accelerator Mass Spectrometry ◽  
State Of The Art ◽  
New Drug ◽  
New Drug Development

scholarly journals Mass spectrometry-based multiplexing for the analysis of biomarkers in drug development and clinical diagnostics — How much is too much?

2012 ◽  
Vol 105 ◽  
pp. 32-38 ◽  
Author(s):  
Uwe Christians ◽  
Jacek Klepacki ◽  
Touraj Shokati ◽  
Jost Klawitter ◽  
Jelena Klawitter
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Clinical Diagnostics
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