Histopathology Evaluation of Cartilage Disease and Repair

2020 ◽  
pp. 371-388
Author(s):  
Kenneth P. H. Pritzker ◽  
Harpal K. Gahunia
Keyword(s):  
2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Francesco Perdisa ◽  
Natalia Gostyńska ◽  
Alice Roffi ◽  
Giuseppe Filardo ◽  
Maurilio Marcacci ◽  
...  

Among the current therapeutic approaches for the regeneration of damaged articular cartilage, none has yet proven to offer results comparable to those of native hyaline cartilage. Recently, it has been claimed that the use of mesenchymal stem cells (MSCs) provides greater regenerative potential than differentiated cells, such as chondrocytes. Among the different kinds of MSCs available, adipose-derived mesenchymal stem cells (ADSCs) are emerging due to their abundancy and easiness to harvest. However, their mechanism of action and potential for cartilage regeneration are still under investigation, and many other aspects still need to be clarified. The aim of this systematic review is to give an overview ofin vivostudies dealing with ADSCs, by summarizing the main evidence for the treatment of cartilage disease of the knee.


2010 ◽  
Vol 18 ◽  
pp. S55
Author(s):  
E. Landman ◽  
R. Miclea ◽  
C. van Blitterswijk ◽  
M. Karperien

2021 ◽  
Author(s):  
Jiaxu Wang ◽  
Xin Guan ◽  
Lele Zhang ◽  
Shuilin Shao ◽  
Bo Gao ◽  
...  

Abstract Purpose Osteoarthritis is one of the most common chronic diseases nowadays, and can cause serious physical illness and economic burden. Cartilage degeneration is one of primary reasons for osteoarthritis, but there were not thorough studies on cartilage lesions. Methods miR-338-5p and miR-4776-3p were overexpressed and knocked down in SW1353 cells. Dual luciferase assay is used to detect the binding of miR-338-5p, miR-4776-3p and SOX6. The expression of MMP13, TNFA, IL6, MCP1, PARP, Runx2, ALP, OPN, WNT4, WNT16, TRACP and CTSK was quantified by qPCR. And the expression of WNT4 at the protein level was quantified by WB. Results In this study, we found miR-338-5p and miR-4776-3p showed significantly high expression on cartilage in osteoarthritis through bioinformatics methods, and verified miR-338-5p and miR-4776-3p can improve catabolism, and trigger biological processes such as inflammation and apoptosis. Meanwhile we validated miR-338-5p and miR-4776-3p may play negative regulation in the process of bone biology. Conclusions Our study showed that miR-338-5p and miR-4776-3p can be regarded as medium of articular cartilage degeneration, and it provided new biomarker of early diagnosis in cartilage disease and osteoarthritis.


2013 ◽  
Vol 12 (2) ◽  
pp. 239
Author(s):  
Marlon Francys Vidmar ◽  
Naiana Muntini ◽  
Luiza Parizotto Audino ◽  
Carlos Rafael Almeida ◽  
Gilnei Lopes Pimentel

<div>Introdução: Lesões na cartilagem articular são atualmente uma das principais causas de cuidados de saúde no mundo, na medida em que elas se tornaram um problema de saúde pública, sobretudo nos países em que a expectativa de vida aumentou, o que também tem aumentado nas patologias articulares. Objetivo: Analisar o efeito da mobilização passiva contínua sobre a dor e amplitude de movimento em pós-operatório de lesão condral traumática de joelho. Metodologia: O estudo foi realizado de março a outubro de</div><div>2010. Desfechos estudados: Dor e amplitude de movimento. Descritores: “Cartilage Disease”, “knee injury”, “cartilage”, “fracture cartilage”, “motion therapy”, “continuous passive”, “continuous passive movement”, “therapy”, “passive movement therapy”, “continuous”, “movement therapy”, “continuous passive”, “passive motion therapy”, “continuous passive motion therapy”, “CPM therapy”, “CPM therapies”, “therapies”, “therapy, CPM”. O tratamento permanece controverso, imprevisível e impreciso na medida</div><div>em que as indicações estão sem causa, e às vezes, é impraticável no que se refere aos regimes de reabilitação e custos de entrega efetiva e da recuperação. Resultados: indicaram eficácia no tratamento das lesões de cartilagem, principalmente no que se refere à dor. E, por fim, deixa-se espaço para que outros pesquisadores busquem mais evidências científicas sobre a MPC, já que a pobreza</div><div>do acervo consultado nos impossibilita de realizar um estudo mais aprimorado.</div>


2019 ◽  
Vol 27 ◽  
pp. S192
Author(s):  
S. Asghar ◽  
G. Litherland ◽  
D. Meek ◽  
J. Cole ◽  
J. Lockhart ◽  
...  

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Lars V von Engelhardt ◽  
Matthias Lahner ◽  
André Klussmann ◽  
Bertil Bouillon ◽  
Andreas Dàvid ◽  
...  

2010 ◽  
Vol 18 ◽  
pp. S99-S100
Author(s):  
C. Jayadev ◽  
R. Rout ◽  
S.M. McDonnell ◽  
A.P. Hollander ◽  
I. Clark ◽  
...  

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