Biophysical Interactions of Direct AMPK Activators

Author(s):  
Ravi G. Kurumbail ◽  
Graham M. West ◽  
Venkatasubramanian Dharmarajan ◽  
Kris A. Borzilleri ◽  
Jane M. Withka ◽  
...  
2019 ◽  
Vol 38 (8) ◽  
pp. 2389-2401
Author(s):  
Amer M. Alanazi ◽  
Azmat Ali Khan ◽  
Md. Tabish Rehman ◽  
Mumtaz Jabeen ◽  
Nasir Algrain ◽  
...  

2012 ◽  
Vol 60 (3) ◽  
pp. 353-365 ◽  
Author(s):  
Sergio Augusto Coelho-Souza ◽  
Maria Soledad López ◽  
Jean Remy Davee Guimarães ◽  
Ricardo Coutinho ◽  
Rogério Nader Candella

The rising of cold water from deeper levels characterizes coastal upwelling systems. This flow makes nutrients available in the euphotic layer, which enhances phytoplankton production and growth. On the Brazilian coast, upwelling is most intense in the Cabo Frio region (RJ). The basic knowledge of this system was reviewed in accordance with concepts of biophysical interactions. The high frequency and amplitude of the prevailing winds are the main factor promoting the rise of South Atlantic Central Water, but meanders and eddies in the Brazil Current as well as local topography and coast line are also important. Upwelling events are common during spring/summer seasons. Primary biomass is exported by virtue of the water circulation and is also controlled by rapid zooplankton predation. Small pelagic fish regulate plankton growth and in their turn are preyed on by predatory fish. Sardine furnishes an important regional fish stock. Shoreline irregularities define the embayment formation of the Marine Extractive Reserve of Arraial do Cabo making it an area with evident different intensities of upwelled water that harbors high species diversity. Consequently, on a small spatial scale there are environments with tropical and subtropical features, a point to be explored as a particularity of this ecosystem.


2017 ◽  
Author(s):  
Manasi A. Pethe ◽  
Aliza B. Rubenstein ◽  
Dmitri Zorine ◽  
Sagar D. Khare

Biophysical interactions between proteins and peptides are key determinants of genotype-fitness landscapes, but an understanding of how molecular structure and residue-level energetics at protein-peptide interfaces shape functional landscapes remains elusive. Combining information from yeast-based library screening, next-generation sequencing and structure-based modeling, we report comprehensive sequence-energetics-function mapping of the specificity landscape of the Hepatitis C Virus (HCV) NS3/4A protease, whose function — site-specific cleavages of the viral polyprotein — is a key determinant of viral fitness. We elucidate the cleavability of 3.2 million substrate variants by the HCV protease and find extensive clustering of cleavable and uncleavable motifs in sequence space indicating mutational robustness, and thereby providing a plausible molecular mechanism to buffer the effects of low replicative fidelity of this RNA virus. Specificity landscapes of known drug-resistant variants are similarly clustered. Our results highlight the key and constraining role of molecular-level energetics in shaping plateau-like fitness landscapes from quasispecies theory.


2020 ◽  
Vol 44 (40) ◽  
pp. 17236-17244
Author(s):  
Douglas H. Nakahata ◽  
Raphael E. F. de Paiva ◽  
Wilton R. Lustri ◽  
Pedro P. Corbi

Cu–(N^N)–sulfonamide complexes are selective metallonucleases that bind tightly to BSA with no protease activity. These compounds have promising antibacterial properties.


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