Bioinformatics Assembling and Assessment of Novel Coxsackievirus B1 Genome

2018 ◽  
pp. 261-272 ◽  
Author(s):  
Jake Lin ◽  
Bryn Y. Kimura ◽  
Sami Oikarinen ◽  
Matti Nykter
Keyword(s):  
Coxsackievirus B1

scholarly journals Comparison of Monoclonal Gammopathies Linked to Poliovirus or Coxsackievirus vs. Other Infectious Pathogens

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 438
Author(s):  
Jean Harb ◽  
Nicolas Mennesson ◽  
Cassandra Lepetit ◽  
Maeva Fourny ◽  
Margaux Louvois ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
B Cell ◽  
Monoclonal Gammopathy ◽  
Coat Proteins ◽  
Chronic Stimulation ◽  
B Cell Epitopes ◽  
Monoclonal Immunoglobulins ◽  
Self Antigen ◽  
Coxsackievirus B1 ◽  
Undetermined Significance

Chronic stimulation by infectious pathogens or self-antigen glucosylsphingosine (GlcSph) can lead to monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Novel assays such as the multiplex infectious antigen microarray (MIAA) and GlcSph assays, permit identification of targets for >60% purified monoclonal immunoglobulins (Igs). Searching for additional targets, we selected 28 purified monoclonal Igs whose antigen was not represented on the MIAA and GlcSph assays; their specificity of recognition was then analyzed using microarrays consisting of 3760 B-cell epitopes from 196 pathogens. The peptide sequences PALTAVETG and PALTAAETG of the VP1 coat proteins of human poliovirus 1/3 and coxsackievirus B1/B3, respectively, were specifically recognized by 6/28 monoclonal Igs. Re-analysis of patient cohorts showed that purified monoclonal Igs from 10/155 MGUS/SM (6.5%) and 3/147 MM (2.0%) bound to the PALTAVETG or PALTAAETG epitopes. Altogether, PALTAV/AETG-initiated MGUS are not rare and few seem to evolve toward myeloma.

Generation of dsRNAs Targeting VP1 and VP3 Gene Regions of Coxsackievirus B1 Utilizing Bacteriophage ф6 Polymerase Complex

2011 ◽  
Vol 90 (2) ◽  
pp. A62
Author(s):  
Nikolay M. Petrov ◽  
Dennis H. Bamford ◽  
Ralitsa Vassileva-Pencheva ◽  
Angel S. Galabov
Keyword(s):  
Polymerase Complex ◽  
Vp3 Gene ◽  
Coxsackievirus B1

scholarly journals Coxsackievirus B1-induced murine myositis: no evidence for viral persistence

1993 ◽  
Vol 74 (10) ◽  
pp. 2071-2076 ◽  
Author(s):  
J. Zoll ◽  
P. Jongen ◽  
J. Galama ◽  
F. v. Kuppeveld ◽  
W. Melchers
Keyword(s):  
Viral Persistence ◽  
Coxsackievirus B1

scholarly journals Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

Diabetes ◽  
2013 ◽  
Vol 63 (2) ◽  
pp. 655-662 ◽  
Author(s):  
S. Oikarinen ◽  
S. Tauriainen ◽  
D. Hober ◽  
B. Lucas ◽  
A. Vazeou ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Virus Antibody ◽  
Risk Association ◽  
European Populations ◽  
Coxsackievirus B1

scholarly journals Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes

Diabetologia ◽  
2018 ◽  
Vol 61 (5) ◽  
pp. 1193-1202 ◽  
Author(s):  
Amir-Babak Sioofy-Khojine ◽  
Jussi Lehtonen ◽  
Noora Nurminen ◽  
Olli H. Laitinen ◽  
Sami Oikarinen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coxsackievirus B1

scholarly journals Multiple Viral Determinants Mediate Myopathogenicity in Coxsackievirus B1-Induced Chronic Inflammatory Myopathy

2003 ◽  
Vol 77 (21) ◽  
pp. 11849-11854 ◽  
Author(s):  
Patricia E. Tam ◽  
Melissa L. Weber-Sanders ◽  
Ronald P. Messner
Keyword(s):  
Untranslated Region ◽  
Hind Limb ◽  
Inflammatory Myopathy ◽  
Limb Weakness ◽  
3C Protease ◽  
Viral Determinants ◽  
Coxsackievirus B1

ABSTRACT Mice infected with myopathic coxsackievirus B1 Tucson (CVB1T) develop chronic inflammatory myopathy (CIM) consisting of hind limb weakness and inflammation. Amyopathic virus variants are infectious but attenuated for CIM. In this report, viral clones, chimeras, and sequencing were used to identify viral determinants of CIM. Chimeras identified several regions involved in CIM and localized a weakness determinant to nucleotides 2493 to 3200 of VP1. Sequencing of multiple clones and viruses identified five candidate determinants that were strictly conserved in myopathic viruses with one located in the 5′ untranslated region (UTR), three in the VP1 capsid, and one in the 3C protease. Taken together, these studies implicate Tyr-87 and/or Val-136 as candidate determinants of weakness. They also indicate that there are at least two determinants of inflammation and one additional determinant of weakness encoded by myopathic CVB1T.

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