Analysis of Methylation Status of Plant MicroRNAs

2019 ◽  
pp. 285-293
Author(s):  
Susu Chen ◽  
Guodong Ren
Keyword(s):  
Methylation Status

Methylation status of the p16 tumor-supressor and DAP-kinase genes in colon biopsies from normal and ulcerative colitis samples

2007 ◽  
Vol 45 (05) ◽  
Author(s):  
T Hevér-Pálfy ◽  
O Galamb ◽  
S Spisák ◽  
B Galamb ◽  
B Molnár ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Methylation Status ◽  
Tumor Supressor ◽  
Dap Kinase

Methylation status of HOXB4 gene in papillary thyroid carcinoma

2014 ◽  
Author(s):  
Andreea Brehar ◽  
Camelia Procopiuc ◽  
Diana Paun ◽  
Dana Manda ◽  
Sabina Oros ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Methylation Status ◽  
Papillary Thyroid

Epigenetic Profiling Identifies Novel Genes for Ascending Aortic Aneurysm Formation with Bicuspid Aortic Valves

2015 ◽  
Vol 18 (4) ◽  
pp. 134 ◽  
Author(s):  
Asad A Shah
Keyword(s):  
Gene Expression ◽  
Aortic Aneurysm ◽  
Methylation Status ◽  
Aortic Aneurysms ◽  
Aortic Valves ◽  
Ascending Aortic Aneurysm ◽  
Novel Genes ◽  
Aneurysm Formation ◽  
Aortic Replacement ◽  
Bicuspid Aortic Valves

<p><strong>Background:  </strong>Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized.  We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patients.</p><p><strong>Methods:  </strong>Ascending aortic aneurysm tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves.  Genome-wide DNA methylation status was determined on DNA from tissue using the Illumina 450K methylation chip, and gene expression was profiled on the same samples using Illumina Whole-Genome DASL arrays.  Gene methylation and expression were compared between bicuspid and trileaflet individuals using an unadjusted Wilcoxon rank sum test.  </p><p><strong>Results:  </strong>Twenty-seven probes in 9 genes showed significant differential methylation and expression (P&lt;5.5x10<sup>-4</sup>).  The top gene was protein tyrosine phosphatase, non-receptor type 22 (<em>PTPN22</em>), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10<sup>-5</sup>) in bicuspid patients, as compared to tricuspid patients.  Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including <em>ACTA2</em> (4 probes, delta beta range:  -10.0 to -22.9%), which when mutated causes the syndrome of familial thoracic aortic aneurysms and dissections</p><p><strong>Conclusions:  </strong>Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending aortic aneurysms in patients with bicuspid aortic valves, modulated through epigenetic mechanisms.  The top gene was <em>PTPN22</em>, which is involved in T-cell receptor signaling and associated with various immune disorders.  These differences highlight novel potential mechanisms of aneurysm development in the bicuspid population.</p>

Association of methylation status of RASSF1A and APC promoters with prostate cancer

2013 ◽  
Vol 32 (5) ◽  
pp. 479-483
Author(s):  
Yong LIANG ◽  
Bai-ping DONG ◽  
Zhen QIU ◽  
Xin-gang CUI ◽  
Lian-sheng ZHANG ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Methylation Status

DNA Methylation Status of Mash2 in Lungs of Somatic Cell Cloning Bovines*

2010 ◽  
Vol 37 (9) ◽  
pp. 960-966 ◽  
Author(s):  
Jie CHEN ◽  
Dong-Jie LI ◽  
Cui ZHANG ◽  
Ning LI ◽  
Shi-Jie LI
Keyword(s):  
Dna Methylation ◽  
Somatic Cell ◽  
Methylation Status ◽  
Cell Cloning

Serum Markers of Methylation Status in Relation to Brain MRI Measures and Risk of Dementia

2018 ◽  
Author(s):  
Babak Hooshmand ◽  
Helga Refsum ◽  
A. David Smith ◽  
Grégoria Kalpouzos ◽  
Francesca Mangialasche ◽  
...  
Keyword(s):  
Brain Mri ◽  
Methylation Status ◽  
Serum Markers
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