Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library

2019 ◽  
pp. 95-113
Author(s):  
Valentin Jakob ◽  
Saskia Helmsing ◽  
Michael Hust ◽  
Martin Empting
Keyword(s):  
Peptide Library ◽  
Free Construction ◽  
Macrocyclic Peptide

A Macrocyclic Peptide Library with a Structurally Constrained Cyclopropane‐containing Building Block Leads to Thiol‐independent Inhibitors of Phosphoglycerate Mutase

2020 ◽  
Vol 15 (17) ◽  
pp. 2631-2636
Author(s):  
Rika Okuma ◽  
Tomoki Kuwahara ◽  
Takafumi Yoshikane ◽  
Mizuki Watanabe ◽  
Patricia Dranchak ◽  
...  
Keyword(s):  
Building Block ◽  
Peptide Library ◽  
Phosphoglycerate Mutase ◽  
Macrocyclic Peptide

Design and Application of a DNA-Encoded Macrocyclic Peptide Library

2017 ◽  
Vol 13 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Zhengrong Zhu ◽  
Alex Shaginian ◽  
LaShadric C. Grady ◽  
Thomas O’Keeffe ◽  
Xiangguo E. Shi ◽  
...  
Keyword(s):  
Peptide Library ◽  
Macrocyclic Peptide ◽  
Design And Application

DNA-Encoded Macrocyclic Peptide Library

2019 ◽  
pp. 273-284 ◽  
Author(s):  
Zhengrong Zhu ◽  
Alex Shaginian ◽  
La Shadric C. Grady ◽  
Christopher P. Davie ◽  
Kenneth Lind ◽  
...  
Keyword(s):  
Peptide Library ◽  
Macrocyclic Peptide

scholarly journals Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles

2021 ◽  
Author(s):  
Sebastian Dengler ◽  
Pradeep Kumar Mandal ◽  
Lars Allmendinger ◽  
Céline Douat ◽  
Ivan Huc
Keyword(s):  
Important Class ◽  
Hybrid Peptide ◽  
Bioactive Substances ◽  
Macrocyclic Peptides ◽  
Macrocyclic Peptide

Macrocyclic peptides are an important class of bioactive substances. When inserting an aromatic foldamer segment in a macrocyclic peptide, the strong folding propensity of the former may influence the conformation...

Rapid Identification of Substrates for Novel Proteases Using a Combinatorial Peptide Library

2000 ◽  
Vol 2 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Gérard Rossé ◽  
Erich Kueng ◽  
Malcolm G. P. Page ◽  
Vesna Schauer-Vukasinovic ◽  
Thomas Giller ◽  
...  
Keyword(s):  
Rapid Identification ◽  
Peptide Library ◽  
Combinatorial Peptide Library

scholarly journals Unlocking the PIP-box: A peptide library reveals interactions that drive high affinity binding to human PCNA

2021 ◽  
pp. 100773
Author(s):  
Aimee J. Horsfall ◽  
Beth A. Vandborg ◽  
Wioleta Kowalczyk ◽  
Theresa Chav ◽  
Denis B. Scanlon ◽  
...  
Keyword(s):  
Peptide Library ◽  
Affinity Binding ◽  
High Affinity Binding ◽  
High Affinity

scholarly journals Rapid discovery of self-assembling peptides with one-bead one-compound peptide library

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pei-Pei Yang ◽  
Yi-Jing Li ◽  
Yan Cao ◽  
Lu Zhang ◽  
Jia-Qi Wang ◽  
...  
Keyword(s):  
Combinatorial Library ◽  
Rapid Identification ◽  
Screening Strategy ◽  
Peptide Library ◽  
Aqueous Environment ◽  
Self Assembling ◽  
Material Sciences ◽  
The One ◽  
Combinatorial Space ◽  
Simple Screening

AbstractSelf-assembling peptides have shown tremendous potential in the fields of material sciences, nanoscience, and medicine. Because of the vast combinatorial space of even short peptides, identification of self-assembling sequences remains a challenge. Herein, we develop an experimental method to rapidly screen a huge array of peptide sequences for self-assembling property, using the one-bead one-compound (OBOC) combinatorial library method. In this approach, peptides on beads are N-terminally capped with nitro-1,2,3-benzoxadiazole, a hydrophobicity-sensitive fluorescence molecule. Beads displaying self-assembling peptides would fluoresce under aqueous environment. Using this approach, we identify eight pentapeptides, all of which are able to self-assemble into nanoparticles or nanofibers. Some of them are able to interact with and are taken up efficiently by HeLa cells. Intracellular distribution varied among these non-toxic peptidic nanoparticles. This simple screening strategy has enabled rapid identification of self-assembling peptides suitable for the development of nanostructures for various biomedical and material applications.

scholarly journals Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

2021 ◽  
Author(s):  
Amy Emery ◽  
Bryn S. Hardwick ◽  
Alex T. Crooks ◽  
Nadia Milech ◽  
Paul M. Watt ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Target Identification ◽  
Peptide Library

scholarly journals A Macrocyclic Peptide that Serves as a Cocrystallization Ligand and Inhibits the Function of a MATE Family Transporter

Molecules ◽  
2013 ◽  
Vol 18 (9) ◽  
pp. 10514-10530 ◽  
Author(s):  
Christopher Hipolito ◽  
Yoshiki Tanaka ◽  
Takayuki Katoh ◽  
Osamu Nureki ◽  
Hiroaki Suga
Keyword(s):  
Macrocyclic Peptide
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