Cell Therapy for Models of Pain and Traumatic Brain Injury

2007 ◽  
pp. 199-239
Author(s):  
Mary Eaton ◽  
Jacqueline Sagen
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cell Therapy

Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies

2021 ◽  
Author(s):  
Lianxu Cui ◽  
Yasmeen Saeed ◽  
Haomin Li ◽  
Jingli Yang
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Stem Cell ◽  
Brain Injury ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Therapeutic Strategies ◽  
Study Data ◽  
Health Concern ◽  
Standardized Treatment

Traumatic brain injury (TBI) is a serious health concern, yet there is a lack of standardized treatment to combat its long-lasting effects. The objective of the present study was to provide an overview of the limitation of conventional stem cell therapy in the treatment of TBI and to discuss the application of novel acellular therapies and their advanced strategies to enhance the efficacy of stem cells derived therapies in the light of published study data. Moreover, we also discussed the factor to optimize the therapeutic efficiency of stem cell-derived acellular therapy by overcoming the challenges for its clinical translation. Hence, we concluded that acellular therapy possesses the potential to bring a breakthrough in the field of regenerative medicine to treat TBI.

scholarly journals Cell therapies for traumatic brain injury

2008 ◽  
Vol 24 (3-4) ◽  
pp. E18 ◽  
Author(s):  
Matthew T. Harting ◽  
James E. Baumgartner ◽  
Laura L. Worth ◽  
Linda Ewing-Cobbs ◽  
Adrian P. Gee ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Clinical Trials ◽  
Brain Injury ◽  
Cell Therapy ◽  
Adult Stem Cells ◽  
Cell Types ◽  
Current Status ◽  
Cell Therapies ◽  
Current Therapies

Preliminary discoveries of the efficacy of cell therapy are currently being translated to clinical trials. Whereas a significant amount of work has been focused on cell therapy applications for a wide array of diseases, including cardiac disease, bone disease, hepatic disease, and cancer, there continues to be extraordinary anticipation that stem cells will advance the current therapeutic regimen for acute neurological disease. Traumatic brain injury is a devastating event for which current therapies are limited. In this report the authors discuss the current status of using adult stem cells to treat traumatic brain injury, including the basic cell types and potential mechanisms of action, preclinical data, and the initiation of clinical trials.

scholarly journals Human cord blood‐derived regulatory T ‐cell therapy modulates the central and peripheral immune response after traumatic brain injury

2020 ◽  
Vol 9 (8) ◽  
pp. 903-916 ◽  
Author(s):  
Henry W. Caplan ◽  
Karthik S. Prabhakara ◽  
Akshita Kumar ◽  
Naama E. Toledano‐Furman ◽  
Cecilia Martin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Immune Response ◽  
Brain Injury ◽  
T Cell ◽  
Cell Therapy ◽  
Cord Blood ◽  
Regulatory T Cell ◽  
Human Cord Blood ◽  
T Cell Therapy ◽  
Peripheral Immune Response

Bone marrow–derived stromal cell therapy for traumatic brain injury is neuroprotective via stimulation of non-neurologic organ systems

Surgery ◽  
2012 ◽  
Vol 152 (5) ◽  
pp. 790-793 ◽  
Author(s):  
Peter A. Walker ◽  
Shinil K. Shah ◽  
Fernando Jimenez ◽  
Kevin R. Aroom ◽  
Matthew T. Harting ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Bone Marrow ◽  
Brain Injury ◽  
Cell Therapy ◽  
Stromal Cell ◽  
Organ Systems ◽  
Stimulation Of
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