Assessment of Genetic Variability Among Subspecies B1 Human Adenoviruses for Molecular Epidemiology Studies

2007 ◽  
pp. 335-355 ◽  
Author(s):  
Adriana E. Kajon ◽  
Dean D. Erdman
Keyword(s):  
Genetic Variability ◽  
Molecular Epidemiology ◽  
Human Adenoviruses ◽  
Epidemiology Studies

scholarly journals 32P-Post-labelling method improvements for aromatic compound-related molecular epidemiology studies

Mutagenesis ◽  
2007 ◽  
Vol 22 (6) ◽  
pp. 381-385 ◽  
Author(s):  
A. Munnia ◽  
F. Saletta ◽  
A. Allione ◽  
S. Piro ◽  
M. Confortini ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Aromatic Compound ◽  
Epidemiology Studies ◽  
Labelling Method

scholarly journals Molecular epidemiology of dengue viruses in Brazil

2000 ◽  
Vol 16 (1) ◽  
pp. 205-211 ◽  
Author(s):  
Rita Maria Ribeiro Nogueira ◽  
Marize Pereira Miagostovich ◽  
Hermann Gonçalves Schatzmayr
Keyword(s):  
Genetic Variability ◽  
Molecular Epidemiology ◽  
Epidemiological Studies ◽  
Dengue Viruses ◽  
Laboratory Evidence ◽  
Dengue Epidemics

Dengue viruses (DEN) are found as four antigenically distinct serotypes designated DEN-1, 2, 3, and 4. Laboratory evidence that strain-intratypical variation occurs among DEN viruses has been demonstrated since the 1970s, although only with the advances in molecular technologies has it been possible to determine the genetic variability of each serotype. Genotypical identification has proven to be a useful tool for determining the origin and spread of epidemics and to correlate virulence of strains. In this report we present the results of molecular epidemiological studies with the DEN-1 and DEN-2 viruses that caused dengue epidemics in Brazil during the last decade.

scholarly journals Use of short tandem repeat fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies

2014 ◽  
Vol 95 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Victoria C. Edwards ◽  
C. Patrick McClure ◽  
Richard J. P. Brown ◽  
Emma Thompson ◽  
William L. Irving ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
Molecular Epidemiology ◽  
Alternative Explanation ◽  
Sequence Analyses ◽  
Distinct Virus ◽  
Virus Sequence ◽  
Epidemiology Studies ◽  
Short Tandem

Sequence analysis is used to define the molecular epidemiology and evolution of the hepatitis C virus. Whilst most studies have shown that individual patients harbour viruses that are derived from a limited number of highly related strains, some recent reports have shown that some patients can be co-infected with very distinct variants whose frequency can fluctuate greatly. Whilst co-infection with highly divergent strains is possible, an alternative explanation is that such data represent contamination or sample mix-up. In this study, we have shown that DNA fingerprinting techniques can accurately assess sample provenance and differentiate between samples that are truly exhibiting mixed infection from those that harbour distinct virus populations due to sample mix-up. We have argued that this approach should be adopted routinely in virus sequence analyses to validate sample provenance.

Cryopreserving whole blood for functional assays using viable lymphocytes in molecular epidemiology studies

2001 ◽  
Vol 166 (2) ◽  
pp. 155-163 ◽  
Author(s):  
L Cheng ◽  
L.E Wang ◽  
M.R Spitz ◽  
Q Wei
Keyword(s):  
Molecular Epidemiology ◽  
Whole Blood ◽  
Functional Assays ◽  
Epidemiology Studies

scholarly journals Perceptions of molecular epidemiology studies of HIV among stakeholders

2017 ◽  
Vol 6 (3) ◽  
Author(s):  
Cynthia Schairer ◽  
Sanjay R. Mehta ◽  
Staal A. Vinterbo ◽  
Martin Hoenigl ◽  
Michael Kalichman ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Qualitative Interviews ◽  
Public Health Research ◽  
Hiv Care ◽  
Willingness To Participate ◽  
Research Subjects ◽  
Privacy Breaches ◽  
Epidemiology Studies ◽  
Study Participants ◽  
Design And Methods

Background: Advances in viral sequence analysis make it possible to track the spread of infectious pathogens, such as HIV, within a population. When used to study HIV, these analyses (i.e., molecular epidemiology) potentially allow inference of the identity of individual research subjects. Current privacy standards are likely insufficient for this type of public health research. To address this challenge, it will be important to understand how stakeholders feel about the benefits and risks of such research. Design and Methods: To better understand perceived benefits and risks of these research methods, in-depth qualitative interviews were conducted with HIV-infected individuals, individuals at high-risk for contracting HIV, and professionals in HIV care and prevention. To gather additional perspectives, attendees to a public lecture on molecular epidemiology were asked to complete an informal questionnaire. Results: Among those interviewed and polled, there was near unanimous support for using molecular epidemiology to study HIV. Questionnaires showed strong agreement about benefits of molecular epidemiology, but diverse attitudes regarding risks. Interviewees acknowledged several risks, including privacy breaches and provocation of anti-gay sentiment. The interviews also demonstrated a possibility that misunderstandings about molecular epidemiology may affect how risks and benefits are evaluated. Conclusions: While nearly all study participants agree that the benefits of HIV molecular epidemiology outweigh the risks, concerns about privacy must be addressed to ensure continued trust in research institutions and willingness to participate in research.

scholarly journals RESPONSE: Re: Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

2004 ◽  
Vol 96 (22) ◽  
pp. 1722-1723 ◽  
Author(s):  
S. Wacholder ◽  
S. Chanock ◽  
M. Garcia-Closas ◽  
H. A. Katki ◽  
L. El ghormli ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Positive Report ◽  
Epidemiology Studies

scholarly journals Genetic variability of hepatitis A virus

2003 ◽  
Vol 84 (12) ◽  
pp. 3191-3201 ◽  
Author(s):  
Mauro Costa-Mattioli ◽  
Anna Di Napoli ◽  
Virginie Ferré ◽  
Sylviane Billaudel ◽  
Raul Perez-Bercoff ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Molecular Biology ◽  
Genetic Variability ◽  
Molecular Epidemiology ◽  
Mutation Rate ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Genetic Recombination ◽  
Classification Methods ◽  
Evolutionary Mechanisms

Knowledge of the molecular biology of hepatitis A virus (HAV) has increased exponentially since its identification. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. HAV has been characterized by the emergence of different genotypes, three human antigenic variants and only one major serotype. This paper reviews the genetic variability and molecular epidemiology of HAV. Its evolutionary mechanisms are described with particular emphasis on genetic recombination and HAV mutation rate. Genotypic classification methods are also discussed.

scholarly journals Analysis of the transcriptome in molecular epidemiology studies

2013 ◽  
Vol 54 (7) ◽  
pp. 500-517 ◽  
Author(s):  
Cliona M. McHale ◽  
Luoping Zhang ◽  
Reuben Thomas ◽  
Martyn T. Smith
Keyword(s):  
Molecular Epidemiology ◽  
Epidemiology Studies
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