A History of Leydig Cell Research

2007 ◽  
pp. 3-30 ◽  
Author(s):  
A. Kent Christensen
Keyword(s):  
Leydig Cell ◽  
History Of

scholarly journals Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a 16-Year-Old Single Woman: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed Abu-Zaid ◽  
Ayman Azzam ◽  
Lama Abdulhamid Alghuneim ◽  
Mona Tarek Metawee ◽  
Tarek Amin ◽  
...  
Keyword(s):  
Literature Review ◽  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Single Woman ◽  
History Of ◽  
Poorly Differentiated ◽  
Sex Cord Stromal Tumors

Sertoli-Leydig cell tumor (SLCT) of ovary is an exceedingly unusual neoplasm that belongs to a group of sex cord-stromal tumors of ovary and accounts for less than 0.5% of all primary ovarian neoplasms. Very few case reports have been documented in the literature so far. Herein, we report a case of primary poorly differentiated ovarian Sertoli-Leydig cell tumor (SLCT) involving the left ovary in a 16-year-old single woman who presented with a 3-month history of a pelviabdominal mass, acne, hirsutism, and menstrual irregularities. In addition, a literature review on ovarian SLCTs is provided.

Ovarian Leydig cell tumor and postmenopausal hirsutism with signs of virilisation

2021 ◽  
Vol 14 (3) ◽  
pp. e240937
Author(s):  
Cátia Ferrinho ◽  
Eugénia Silva ◽  
Manuela Oliveira ◽  
João Sequeira Duarte
Keyword(s):  
Leydig Cell ◽  
Transvaginal Ultrasound ◽  
Uterine Fibroids ◽  
Histopathological Diagnosis ◽  
Bilateral Oophorectomy ◽  
Androgenic Alopecia ◽  
Regular Menses ◽  
Leydig Cell Tumour ◽  
History Of ◽  
The Voice

A 71-year-old woman was referred to the endocrinology clinic to investigate postmenopausal hirsutism with 10 years of evolution. She had history of regular menses and menopause with 50 years old. Physical examination showed a male pattern facies, deepening of the voice, androgenic alopecia and hirsutism with a score of 23 according to the modified Ferriman-Gallwey scale. Testosterone and androstenedione were increased. Transvaginal ultrasound, abdominal and pelvic CT showed uterine fibroids with no pathological findings in the adrenals or ovaries. Since she had postmenopausal vaginal bleeding, uterine fibroids and suspicion of an ovarian source for her hyperandrogenism, total hysterectomy and bilateral oophorectomy were performed. Histopathological diagnosis was a Leydig cell tumour located in left ovary and endometrial carcinoma. Improvement of hirsutism was started to notice 1 month after the surgery and she was referred to the oncology clinic for adjuvant treatment.

scholarly journals Occult Leydig Cell Tumour Presenting as Bilateral Gynaecomastia. Case Report and Literature Review

2005 ◽  
Vol 5 ◽  
pp. 884-887
Author(s):  
A. B. Patel ◽  
L. Wilson ◽  
A. Rane
Keyword(s):  
Leydig Cell ◽  
Surgical Excision ◽  
Cell Tumour ◽  
Left Testis ◽  
Threatening Condition ◽  
Leydig Cell Tumour ◽  
Life Threatening ◽  
Hypoechoic Mass ◽  
History Of ◽  
Secondary Hypogonadism

Gynaecomastia is the most common benign breast disorder in men. Among the various causes, testicular malignancies are an uncommon, life-threatening condition requiring prompt diagnosis and treatment. The case of a 28-year-old man is discussed, who presented with a 6-month history of painful bilateral gynaecomastia with no abnormality on clinical or biochemical examination. The patient's symptoms spontaneously resolved within 4 weeks. He then represented 10 years later with similar symptoms and an associated secondary hypogonadism. Ultrasound imaging revealed a clinically occult, hypoechoic mass in the left testis (Leydig cell tumour on histology). Clinical and hormonal findings normalized following surgical excision. This report underlines the importance in clinical practice of ultrasonographic evaluation of the testis, in all patients with gynaecomastia, despite unremarkable findings on physical examination.

scholarly journals The triphasic nature of Leydig cell development in humans, and comments on nomenclature

2001 ◽  
Vol 168 (2) ◽  
pp. 213-216 ◽  
Author(s):  
FP Prince
Keyword(s):  
Leydig Cell ◽  
Neonatal Period ◽  
Adult Life ◽  
Cell Development ◽  
Fetal Life ◽  
Testosterone Production ◽  
Functional Implications ◽  
History Of ◽  
Qualitative Nature ◽  
Developmental Phases

Leydig cell development in humans, although for years described as being biphasic, with fetal and adult phases of maturation, is better considered as a triphasic developmental phenomenon. The morphological literature is summarized in this commentary. Although the majority of studies are of a qualitative nature and many questions remain as to the relative and absolute numbers of cells involved in these developmental phases, this literature is more consistent with a triphasic developmental pattern. This view of Leydig cell development is in accord with the well-known triphasic history of testosterone production, i.e. peaks at 14-18 weeks of fetal life, 2-3 months after birth, and from puberty throughout adult life. It is also significant that the neonatal phase of testosterone production is dependent upon reactivation of the hypothalamic-pituitary-testicular axis (HPT). The current interest in the functional implications of the neonatal period will be better served by considering human Leydig cell development as triphasic.

scholarly journals Tumor de Células de Leydig num Doente com Criptorquidia Contralateral: Uma Associação Rara

2020 ◽  
Vol 33 (13) ◽  
Author(s):  
Ricardo Capitão ◽  
Catarina Saraiva ◽  
Clara Cunha ◽  
Mónica Martins
Keyword(s):  
Leydig Cell ◽  
Previous History ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Timely Manner ◽  
Testicular Tumors ◽  
History Of ◽  
The Right ◽  
Subsequent Improvement ◽  
Leydig Cell Tumors

Gynecomastia is a frequent sign that may be physiological or caused by various benign or malignant diseases. In rare cases, it may be caused by testicular tumors. We describe a case of progressive gynecomastia at age 20 due to a Leydig cell tumor of the right testicle in a patient with a previous history of left-sided cryptorchidism. The patient underwent orchidectomy and testicular prosthesis placement, with subsequent improvement of gynecomastia and normalization of estrogen. Our case, in addition to demonstrating that gynecomastia may regress if the underlying cause is treated in a timely manner, shows that cryptorchidism may be related with the development of Leydig cell tumors in the same way as it is in other testicular tumors.

scholarly journals A family with Sertoli–Leydig cell tumour, multinodular goiter, and DICER1 mutation

2019 ◽  
Vol 26 (3) ◽  
Author(s):  
M. G. Haley ◽  
P. Bindal ◽  
A. McAuliffe ◽  
J. Vredenburgh
Keyword(s):  
Leydig Cell ◽  
Multinodular Goiter ◽  
Early Recognition ◽  
Adult Population ◽  
Cell Cancer ◽  
Cell Tumour ◽  
Cancer Risks ◽  
Leydig Cell Tumour ◽  
History Of ◽  
Dicer1 Syndrome

Background DICER1 syndrome is an autosomal dominant tumour predisposition syndrome associated with a wide variety of cancerous and noncancerous conditions, including ovarian sex cord–stromal tumours and thyroid conditions, including multinodular goiter. The most common ovarian sex cord–stromal tumour associated with DICER1 syndrome is Sertoli–Leydig cell tumour, with germline DICER1 mutations present in more than 50% of cases. We present a case in which a patient in her late 30s was diagnosed with a Sertoli–Leydig cell tumour in the background of a strong family history of multinodular goiter and Sertoli–Leydig cell tumour with a germline mutation in DICER1.Case Presentation A 38-year-old woman with history of multinodular goiter was found to have stage iiic ovarian Sertoli–Leydig cell cancer after presenting with abdominal pain. She underwent multiple surgeries and chemotherapy. The patient developed rapid disease progression and died 7 months after diagnosis. Seven years earlier, a daughter had experienced the same disease and was found to have a germline DICER1 mutation. The mother had not undergone testing before her own diagnosis.Summary The co-occurrence of Sertoli–Leydig cell tumour and multinodular goiter is highly suggestive of DICER1 syndrome. The recognition of DICER1 syndrome within a family is essential for increased awareness and potential early recognition of complications. Most conditions associated with DICER1 syndrome occur in childhood, and most of the current screening recommendations are specific for childhood and young adulthood. Cancer risks and findings for the adult population are not as well defined. Clinicians who encounter DICER1 syndrome should review recommendations for genetic testing and surveillance and enrol patients in the DICER1 registry.

scholarly journals SUN-011 Beyond PCOS - Ovarian Neoplasms Presenting with Hirsutism and Virilization

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Shourjo Chakravorty ◽  
Brandon Hoard ◽  
Gina Cosentino ◽  
Karen E Friday ◽  
Gabriel Ikponmosa Uwaifo
Keyword(s):  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Total Serum ◽  
Symptom Improvement ◽  
Ovarian Mass ◽  
Multiple Imaging ◽  
History Of ◽  
Androgen Levels

Abstract BACKGROUND: PCOS is the most common cause of hirsutism in women of reproductive age. The presence of virilization in addition to hirsutism should alert to the possibility of less common causes of hyper-androgenization (HA) in this population including otherwise uncommon functional ovarian neoplasms (FON). We present 3 cases of women initially thought to have PCOS in whom virilization was the prime clue to the correct diagnosis of FON. Clinical Case series: Case 1 is a 40yr old woman with obesity and dysmetabolic syndrome referred for hirsutism presumed due to PCOS. She had noted symptoms over 2–3 yrs with amenorrhea and associated infertility. Examination revealed marked hirsutism and virilization with Ferriman-Galleway score (FGS) of 20. Lab tests confirmed marked male range HA. Multiple imaging tests revealed no adrenal or ovarian mass lesions. FDG-PET scan finally revealed a left ovarian focus for which she has left oophorectomy that revealed a 1cm Leydig cell tumor, Her HA resolved post-op and spontaneous periods resumed. Case 2 is a 45yr old woman referred with possible PCOS who had 5 mth history of progressive hirsutism and generalized hypertrichosis, dull lower abdominal pain and amenorrhea. Examination revealed marked hirsutism with generalized hypertrichosis and virilization. FGS was 25 and clitoral index was 935mm2. Lab tests confirmed marked male range HA and abdominopelvic imaging show no adrenal lesions but a 5.2cm left ovarian mass. Left salpingo-oophorectomy revealed a steroid cell tumor and postoperatively her androgen levels normalized. Case 3 is 37 yr old woman with SLE and obesity with prior gastric bypass referred with presumed PCOS but presenting with 1 yr history of progressive hirsutism. She was initially thought to have non classical CAH and treated with oral glucocorticoids with no symptom improvement. Examination revealed marked hirsutism, virilization with elevated FGS and clitoromegaly. Lab tests showed marked male range HA but multiple imaging studies revealed no apparent adrenal or ovarian lesions. Patient had no fertility interests and so had elective total hysterectomy and bilateral salpingo-oophorectomy. Histopathology revealed a 2.5cm left ovarian Leydig cell tumor not apparent at surgery and post op her androgen levels normalized. Conclusion: The distinction between PCOS which is ubiquitous and FON which is rare hinges on careful history and examination. Rapid onset hirsutism with virilization should prompt suspicion of FON. Marked male range HA (total serum testosterone >250ng/dl) is another “red flag” finding. Persistent radiologic search for such lesions should continue as they may not be immediately apparent on routine abdominopelvic imaging.

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