Insulin Resistance, Diabetes, and Cardiovascular Risk in Women and the Paradigm of the Polycystic Ovary Syndrome

Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age30.4±1.2years (mean ± SEM), body mass index (BMI)36.8±1.5 kg/m2) and 26 non-PCOS subjects (age34.1±0.9years, BMI31.5±1.0 kg/m2) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (SI), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.

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Addition of low dose of metformin to the oral contraceptive has no great advantage in terms of cardiovascular risk markers in women with polycystic ovary syndrome regardless insulin resistance

Fertility and Sterility ◽

10.1016/j.fertnstert.2010.07.248 ◽

2010 ◽

Vol 94 (4) ◽

pp. S63-S64 ◽

Cited By ~ 1

Author(s):

C.S. Vieira ◽

J.B.F. Fernandes ◽

G.M. Soares ◽

W.P. Martins ◽

M.F. Silva-de-Sá ◽

...

Keyword(s):

Insulin Resistance ◽

Cardiovascular Risk ◽

Oral Contraceptive ◽

Polycystic Ovary Syndrome ◽

Low Dose ◽

Polycystic Ovary ◽

Risk Markers ◽

Ovary Syndrome

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Biological variation of insulin resistance, testosterone and cardiovascular risk factors in women with polycystic ovary syndrome: modification with rimonabant compared to metformin

http://isrctn.org/> ◽

10.1186/isrctn75758249 ◽

2013 ◽

Author(s):

Stephen Atkin

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Cardiovascular Risk ◽

Polycystic Ovary Syndrome ◽

Cardiovascular Risk Factors ◽

Polycystic Ovary ◽

Biological Variation ◽

Ovary Syndrome

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INFLUENCE OF LIFESTYLE ON THE PROGNOSIS OF POLYCYSTIC OVARY SYNDROME

Health and Society ◽

10.51249/hes01.02.2021.291 ◽

2021 ◽

Keyword(s):

Quality Of Life ◽

Insulin Resistance ◽

Cardiovascular Risk ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Overweight And Obesity ◽

Lifestyle Changes ◽

Ovary Syndrome ◽

Pubmed Database

Polycystic Ovary Syndrome (PCOS) is the most common endocrine-metabolic pathology among women at reproductive age. It has a multifactorial character, and its etiology has not yet been precisely explained. The pathogenesis of PCOS is related to metabolic issues such as hyperandrogenism and insulin resistance, and is also associated with obesity, type 2 diabetes and increased cardiovascular risk. Manifestations such as irregular menstruation, acne, hisurtism and androgenic alopecia are common in addition to the consequent psychological and quality of life impacts. Thus, knowing that the adoption of healthy habits have therapeutic impacts in the face of various signs and symptoms of PCOS, there is a need to analyze the influence of lifestyle on the prognosis of PCOS. The present study carried out its searches in the PUBMED database, using the descriptors "polycystic ovary syndrome", "life style" and "prognosis", using the Boolean operator "and". Inclusion criteria were used: articles written in Portuguese, English and Spanish, published in the last 5 years. 19 results were obtained, 5 of which were excluded, resulting in 14 articles chosen for theoretical reference. The influence of lifestyle on the prognosis of PCOS is notorious, especially in patients with overweight and obesity. Thus, healthy behaviors have the potential to improve pathological conditions and bad habits demonstrate that they can induce clinical manifestations of PCOS in predisposed people. Lifestyle changes, mainly associated with weight loss, show improvements in aspects such as insulin resistance, free testosterone, acne, hirsutism and reproductive function, reduced cardiovascular risk, in addition to positively influence to the psychic and quality of life in analyzed patients. Therapeutic strategies that combine lifestyle changes and drug interventions have been shown to be more effective, as well as strategies structered with the monitoring of professionals tend to increase adherence to treatment.

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