Photodynamic Therapy of Head and Neck Cancers

2010 ◽  
pp. 281-293 ◽  
Author(s):  
Merrill A. Biel
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Head And Neck Cancers

Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy

2021 ◽  
Vol 28 ◽  
Author(s):  
Ivana Ratkaj ◽  
Martina Mušković ◽  
Nela Malatesti
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Tumour Progression ◽  
Neck Region ◽  
Angiogenesis Inhibitors ◽  
Tumour Microenvironment ◽  
Head And Neck Cancers ◽  
Skin Cancers ◽  
Tumour Vasculature ◽  
Optimal Drug

Background: Photodynamic therapy (PDT), in comparison to other skin cancers, is still far less effective for melanoma, due to the strong absorbance and the role of melanin in cytoprotection. The tumour microenvironment (TME) has a significant role in tumour progression, and the hypoxic TME is one of the main reasons for melanoma progression to metastasis and its resistance to PDT. Hypoxia is also a feature of solid tumours in the head and neck region that indicates a negative prognosis. Objective: The aim of this study was to individuate and describe systematically the main strategiesthe main strategies systematically in targeting the TME, especially hypoxia, in PDT against melanoma and head and neck cancers (HNC), and assess the current success in their application. Methods: PubMed, was used for searching, in MEDLINE and other databases were used for searching, for the most recent publications on PDT against melanoma and HNC in combination with the TME targeting and hypoxia. Results: In PDT for melanoma and HNC, it is very important to control hypoxia levels, and, amongst the different approaches, oxygen self-supply systems are often applied. Vascular targeting is promising, but to improve it, optimal drug-light interval, and formulation to increase the accumulation of the photosensitiser in the tumour vasculature, have to be established. On the other side, the use of angiogenesis inhibitors, such as those interfering with VEGF signalling are somewhat less successful than expected and need to be further investigated. Conclusion: Combination The combination of PDT with immunotherapy by using multifunctional nanoparticles continues to develop and seems to be the most promising for achieving a complete and lasting antitumour effect.

scholarly journals Clinical Outcomes of Photodynamic Therapy for Head-and-Neck Cancer

2003 ◽  
Vol 2 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Pei-Jen Lou ◽  
Linda Jones ◽  
Colin Hopper
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Overall Response Rate ◽  
Early Stage ◽  
Therapeutic Option ◽  
Similar Efficacy ◽  
Head And Neck Cancers ◽  
The Past ◽  
Neck Tumors

Head-and-neck cancers not only carry poor prognoses, but also reduced quality of life for the patients. Disease control is often achieved at the expense of substantial functional loss and disfigurement. Photodynamic therapy (PDT) is particularly well suited to the treatment of head-and-neck-tumors because it has little effect on underlying functional structures and has an excellent cosmetic outcome. Studies in the past decades have shown that PDT is of similar efficacy as traditional measures in the treatment of early-stage head-and-neck cancers with an overall response rate of 85%–100%, with up to 75% of the complete responses sustained at 2 years after PDT. For advanced head-and-neck cancers, studies were also conducted to evaluate the palliative effects of PDT. Overall, a 58%–70% palliative benefit can be observed in these patients. Using interstitial PDT, the median survival of the patients with recurrent unresectable head-and-neck cancers can be improved to 14 months (cf. 226 days by using surface illumination PDT). PDT is thus a therapeutic option that may prove a useful addition to the armamentarium of the integrated head and neck oncology team.

scholarly journals Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers

2019 ◽  
Vol 20 (20) ◽  
pp. 5027 ◽  
Author(s):  
Lilla Pethő ◽  
József Murányi ◽  
Kinga Pénzes ◽  
Bianka Gurbi ◽  
Diána Brauswetter ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Protoporphyrin Ix ◽  
Gonadotropin Releasing Hormone ◽  
Head And Neck Cancers ◽  
Human Pituitary ◽  
Releasing Hormone ◽  
Pharyngeal Carcinoma ◽  
Targeting Peptide

Head and neck squamous cell carcinomas (HNSCC) have a high mortality rate, although several potential therapeutic targets have already been identified. Gonadotropin-releasing hormone receptor (GnRH-R) expression is less studied in head and neck cancers, hence, we investigated the therapeutic relevance of GnRH-R targeting in HNSCC patients. Our results indicate that half of the patient-derived samples showed high GnRH-R expression, which was associated with worse prognosis, making this receptor a promising target for GnRH-based drug delivery. Photodynamic therapy is a clinically approved treatment for HNSCC, and the efficacy and selectivity may be enhanced by the covalent conjugation of the photosensitizer to a GnRH-R targeting peptide. Several native ligands, gonadotropin-releasing hormone (GnRH) isoforms, are known to target GnRH-R effectively. Therefore, different 4Lys(Bu) modified GnRH analogs were designed and conjugated to protoporphyrin IX. The receptor binding potency of the novel conjugates was measured on human pituitary and human prostate cancer cells, indicating only slightly lower GnRH-R affinity than the peptides. The in vitro cell viability inhibition was tested on Detroit-562 human pharyngeal carcinoma cells that express GnRH-R in high levels, and the results showed that all conjugates were more effective than the free protoporphyrin IX.

Clinical photodynamic therapy of head and neck cancers—A review of applications and outcomes

2005 ◽  
Vol 2 (3) ◽  
pp. 205-222 ◽  
Author(s):  
R.R. Allison ◽  
R.E. Cuenca ◽  
G.H. Downie ◽  
P. Camnitz ◽  
B. Brodish ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Head And Neck Cancers

Photodynamic therapy of head and neck cancers

1995 ◽  
Vol 11 (5) ◽  
pp. 355-359 ◽  
Author(s):  
Merrill A. Biel
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Head And Neck Cancers

Organ sparing neck dissection for the treatment of head and neck cancers in children

2017 ◽  
Vol 16 (4) ◽  
pp. 56-61
Author(s):  
N.S. Grachev ◽  
◽  
I.N. Vorozhtsov ◽  
N.V. Babaskina ◽  
E.Yu. Iaremenko ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neck Dissection ◽  
Head And Neck Cancers ◽  
Organ Sparing
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