Silicon Nanowire Biosensor for Ultrasensitive and Label-Free Direct Detection of miRNAs

2010 ◽  
pp. 111-121 ◽  
Author(s):  
Guo-Jun Zhang
Keyword(s):  
Direct Detection ◽  
Silicon Nanowire ◽  
Label Free

scholarly journals Label-Free Direct Detection of miRNAs with Poly-Silicon Nanowire Biosensors

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145160 ◽  
Author(s):  
Jing He ◽  
Jianjun Zhu ◽  
Changguo Gong ◽  
Jiming Qi ◽  
Han Xiao ◽  
...  
Keyword(s):  
Direct Detection ◽  
Silicon Nanowire ◽  
Label Free ◽  
Poly Silicon

Label-free direct detection of MiRNAs with silicon nanowire biosensors

2009 ◽  
Vol 24 (8) ◽  
pp. 2504-2508 ◽  
Author(s):  
Guo-Jun Zhang ◽  
Jay Huiyi Chua ◽  
Ru-Ern Chee ◽  
Ajay Agarwal ◽  
She Mein Wong
Keyword(s):  
Direct Detection ◽  
Silicon Nanowire ◽  
Label Free

A microfluidic device with integrated impedance detection for λ-DNA

2003 ◽  
Vol 773 ◽  
Author(s):  
Myung-Il Park ◽  
Jonging Hong ◽  
Dae Sung Yoon ◽  
Chong-Ook Park ◽  
Geunbae Im
Keyword(s):  
Microfluidic Device ◽  
Electrochemical Impedance ◽  
Direct Detection ◽  
Full Potential ◽  
Label Free ◽  
Buffer Solution ◽  
Detection Systems ◽  
Significant Difference ◽  
Detection Of Biomolecules ◽  
Impedance Magnitude

AbstractThe large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.

scholarly journals Biologically sensitive field-effect transistors: from ISFETs to NanoFETs

2016 ◽  
Vol 60 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Vivek Pachauri ◽  
Sven Ingebrandt
Keyword(s):  
Field Effect ◽  
Gate Dielectric ◽  
Gate Dielectrics ◽  
Field Effect Transistors ◽  
Silicon Nanowire ◽  
Label Free ◽  
Biomolecular Detection ◽  
New Device ◽  
Label Free Detection ◽  
History Of

Biologically sensitive field-effect transistors (BioFETs) are one of the most abundant classes of electronic sensors for biomolecular detection. Most of the time these sensors are realized as classical ion-sensitive field-effect transistors (ISFETs) having non-metallized gate dielectrics facing an electrolyte solution. In ISFETs, a semiconductor material is used as the active transducer element covered by a gate dielectric layer which is electronically sensitive to the (bio-)chemical changes that occur on its surface. This review will provide a brief overview of the history of ISFET biosensors with general operation concepts and sensing mechanisms. We also discuss silicon nanowire-based ISFETs (SiNW FETs) as the modern nanoscale version of classical ISFETs, as well as strategies to functionalize them with biologically sensitive layers. We include in our discussion other ISFET types based on nanomaterials such as carbon nanotubes, metal oxides and so on. The latest examples of highly sensitive label-free detection of deoxyribonucleic acid (DNA) molecules using SiNW FETs and single-cell recordings for drug screening and other applications of ISFETs will be highlighted. Finally, we suggest new device platforms and newly developed, miniaturized read-out tools with multichannel potentiometric and impedimetric measurement capabilities for future biomedical applications.

scholarly journals Wafer-scale HfO2 encapsulated silicon nanowire field effect transistor for efficient label-free DNA hybridization detection in dry environment

2019 ◽  
Vol 30 (18) ◽  
pp. 184002 ◽  
Author(s):  
Ganesh Jayakumar ◽  
Maxime Legallais ◽  
Per-Erik Hellström ◽  
Mireille Mouis ◽  
Isabelle Pignot-Paintrand ◽  
...  
Keyword(s):  
Dna Hybridization ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
Label Free ◽  
Wafer Scale ◽  
Free Dna ◽  
Effect Transistor ◽  
Hybridization Detection

scholarly journals Direct detection of label-free blood fingermarks by SECM imaging

2019 ◽  
Vol 102 ◽  
pp. 89-93 ◽  
Author(s):  
Lu Tian ◽  
Xiaohui Wang ◽  
Liang Zhao ◽  
Mi Shi ◽  
Hongjuan Wang ◽  
...  
Keyword(s):  
Direct Detection ◽  
Label Free
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