DNA Hybridization Detection based on Plasmonic Photonic Crystal Fiber

A novel design of surface plasmon (SP) photonic crystal fiber (PCF) for DNA hybridization detection is proposed and analyzed. The suggested biosensor relies on plasmonic D-shaped PCF configuration. Accordingly, the core guided mode in the silica core is coupled with the SP mode near the plasmonic layer. The resonance wavelength is sensitive to the DNA hybridization process. Therefore, the suggested bio-sensor is studied to maximize the DNA hybridization detection sensitivity by adjusting the structural geometrical parameters. The numerical results are obtained using full vectorial finite element method with perfectly matched layer boundary condition and non-uniform meshing capabilities. The reported D-shaped PCF offers high wavelength sensitivity of 405.4 nm/RIU with a corresponding amplitude sensitivity of 5.65 RIU−1. Consequently, the applications based on DNA classification can be potentially implemented by the reported biosensor.

Development of an electrochemical DNA biosensor based on Quercetin as a new electroactive indicator for DNA hybridization detection

Electrochemical DNA biosensor is designed for detection of specific target DNA after hybridization with complementary probe DNA immobilized onto glassy carbon electrode surface. Quercetin was successfully used as a new...