Bone Marrow–Derived Cells as Treatment Vehicles in the Central Nervous System

2011 ◽  
pp. 109-123
Author(s):  
Coral-Ann B. Lewis ◽  
Fabio M. Rossi ◽  
Charles Krieger
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
The Central Nervous System ◽  
Bone Marrow Derived Cells

Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis

Glia ◽  
2006 ◽  
Vol 53 (7) ◽  
pp. 744-753 ◽  
Author(s):  
Jennifer N. Solomon ◽  
Coral-Ann B. Lewis ◽  
Bahareh Ajami ◽  
Stephane Y. Corbel ◽  
Fabio M.V. Rossi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Amyotrophic Lateral Sclerosis ◽  
Nervous System ◽  
Mouse Model ◽  
The Central Nervous System ◽  
Bone Marrow Derived Cells ◽  
Lateral Sclerosis

Migration of Bone Marrow-Derived Cells Into the Central Nervous System in Models of Neurodegeneration

2013 ◽  
Vol 521 (17) ◽  
pp. Spc1-Spc1 ◽  
Author(s):  
Antoine Lampron ◽  
Pedro M. Pimentel-Coelho ◽  
Serge Rivest
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
The Central Nervous System ◽  
Bone Marrow Derived Cells

Mammalian Bone Marrow Acetylcholinesterase

1982 ◽  
Vol 40 ◽  
pp. 44-45
Author(s):  
Ezzatollah Keyhani
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Common Property ◽  
Extracellular Medium ◽  
The Central Nervous System ◽  
The Common ◽  
Mammalian Bone

Acetylcholinesterase (EC 3.1.1.7) (ACHE) has been localized at cholinergic junctions both in the central nervous system and at the periphery and it functions in neurotransmission. ACHE was also found in other tissues without involvement in neurotransmission, but exhibiting the common property of transporting water and ions. This communication describes intracellular ACHE in mammalian bone marrow and its secretion into the extracellular medium.

scholarly journals Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice

2009 ◽  
Vol 9 (1) ◽  
pp. 1 ◽  
Author(s):  
Irene Bergwerf ◽  
Nathalie De Vocht ◽  
Bart Tambuyzer ◽  
Jacob Verschueren ◽  
Kristien Reekmans ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Reporter Gene ◽  
Stromal Cells ◽  
The Central Nervous System ◽  
Immunocompetent Mice ◽  
Gene Expressing

scholarly journals Quantitative and phenotypic analysis of bone marrow-derived cells in the intact and inflamed central nervous system

2011 ◽  
Vol 5 (5) ◽  
pp. 373-381 ◽  
Author(s):  
Martin A. Short ◽  
Naomi Campanale ◽  
Sara Litwak ◽  
Claude C.A. Bernard
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Phenotypic Analysis ◽  
Bone Marrow Derived Cells

scholarly journals After Injection into the Striatum, in Vitro-Differentiated Microglia- and Bone Marrow-Derived Dendritic Cells Can Leave the Central Nervous System via the Blood Stream

2008 ◽  
Vol 173 (6) ◽  
pp. 1669-1681 ◽  
Author(s):  
Sonja Hochmeister ◽  
Manuel Zeitelhofer ◽  
Jan Bauer ◽  
Eva-Maria Nicolussi ◽  
Marie-Therese Fischer ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Dendritic Cells ◽  
Blood Stream ◽  
The Central Nervous System

scholarly journals Mantle Cell Lymphoma recurrence and involvement of the central nervous system after bone marrow transplantation: case report.

2021 ◽  
Author(s):  
Rafael Bragança Rodrigues Matias ◽  
Bruna Cardoso de Mattos Boccalini ◽  
Renata de Oliveira Costa ◽  
Maria Fernanda Mélega Mingossi
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Case Report ◽  
Bone Marrow Transplantation ◽  
Mantle Cell Lymphoma ◽  
Marrow Transplantation ◽  
Cell Lymphoma ◽  
Mantle Cell ◽  
The Central Nervous System

Introduction: Mantle cell lymphoma (MCL) is a subtype of uncommon nonHodgkin lymphoma. The involvement of the central nervous system (CNS) is uncommon in the course of the disease. Objective: To report a case of recurrence of MCL in the CNS as the first manifestation, after chemotherapy and bone marrow transplantation. Case report: Male patient, 49 years old, with no previous comorbidities diagnosed with stage IV MCL (bone marrow), submitted to chemotherapy and autologous transplantation. After two years, he sought out the neurology clinic with a complaint of blurred vision. Neurological examination: without motor deficit; bilateral partial ptosis, bilateral divergent strabismus, tongue shift to the right. CSF with 230 leukocytes/mm³, 70% of lymphocytes, glucose of 71 mg /dl and protein of 85 mg /dl; Skull MRI demonstrated bilateral and symmetrical enhancement of segments of the cisterns of the optic and oculomotor nerves; Trigeminal, facial, vestibulocochlear and glossopharyngeal, vagus and accessory nerves more exuberant on the left. CSF immunophenotyping showed CD19, CD5 and Kappa positive monoclonal, compatible with MCL recurrence. Intrathecal and systemic chemotherapy with methotrexate were initiated. Discussion: Risk of recurrence of MCL and infiltration of the CNS is uncommon (3.9 - 5%). The patient did not show any signs of systemic involvement, only the neurological findings, which is atypical since the neurological presentation is more associated with recurrence of MCL with a course of systemic findings. Conclusion:The authors point out that in patients with treated MCL who have neurological manifestations without systemic findings, tumor recurrence should be considered.

scholarly journals Expression of (pro)renin receptor and angiotensin II type 1 receptor on bone marrow‐related neurons in the central nervous system

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Christie Diane Kimball ◽  
Wencheng Li ◽  
Andrea Zsombok ◽  
Andrei Derbenev ◽  
Joseph Francis ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Angiotensin Ii ◽  
The Central Nervous System
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