Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis

Glia ◽  
2006 ◽  
Vol 53 (7) ◽  
pp. 744-753 ◽  
Author(s):  
Jennifer N. Solomon ◽  
Coral-Ann B. Lewis ◽  
Bahareh Ajami ◽  
Stephane Y. Corbel ◽  
Fabio M.V. Rossi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Amyotrophic Lateral Sclerosis ◽  
Nervous System ◽  
Mouse Model ◽  
The Central Nervous System ◽  
Bone Marrow Derived Cells ◽  
Lateral Sclerosis

scholarly journals Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS

Metallomics ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 1002-1011 ◽  
Author(s):  
J. B. Hilton ◽  
A. R. White ◽  
P. J. Crouch
Keyword(s):  
Central Nervous System ◽  
Amyotrophic Lateral Sclerosis ◽  
Nervous System ◽  
Mouse Model ◽  
Limited Capacity ◽  
Mutant Sod1 ◽  
The Central Nervous System ◽  
Sod1 Mouse ◽  
Lateral Sclerosis

It is unclear why ubiquitous expression of mutant SOD1 selectively affects the central nervous system in amyotrophic lateral sclerosis. Here we hypothesise that the central nervous system is primarily affected because, unlike other tissues, it has relatively limited capacity to satiate an increased requirement for Cu.

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