Ca2+ Imaging as a Tool to Assess TRP Channel Function in Murine Distal Nephrons

2013 ◽  
pp. 371-384 ◽  
Author(s):  
Mykola Mamenko ◽  
Oleg Zaika ◽  
Roger G. O’Neil ◽  
Oleh Pochynyuk
Keyword(s):  
Trp Channel ◽  
Channel Function

Transient receptor potential (TRP) channel function in the reproductive axis

Cell Calcium ◽  
2017 ◽  
Vol 67 ◽  
pp. 138-147 ◽  
Author(s):  
Viktoria Götz ◽  
Sen Qiao ◽  
Andreas Beck ◽  
Ulrich Boehm
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Trp Channel ◽  
Channel Function ◽  
Reproductive Axis ◽  
Transient Receptor

scholarly journals TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity

2015 ◽  
Vol 208 (1) ◽  
pp. 89-107 ◽  
Author(s):  
Dimitra Gkika ◽  
Loic Lemonnier ◽  
George Shapovalov ◽  
Dmitri Gordienko ◽  
Céline Poux ◽  
...  
Keyword(s):  
Associated Factors ◽  
Trp Channel ◽  
Channel Activity ◽  
Trpm8 Channel ◽  
Channel Function ◽  
Intracellular Proteins ◽  
Opposing Effects ◽  
Partner Proteins ◽  
Cold Sensor ◽  
Novel Protein

TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-temperature-sensing organs, and is regulated by downstream receptor–activated signaling pathways. However, little is known about the intracellular proteins necessary for channel function. Here, we identify two previously unknown proteins, which we have named “TRP channel–associated factors” (TCAFs), as new TRPM8 partner proteins, and we demonstrate that they are necessary for channel function. TCAF1 and TCAF2 both bind to the TRPM8 channel and promote its trafficking to the cell surface. However, they exert opposing effects on TRPM8 gating properties. Functional interaction of TCAF1/TRPM8 also leads to a reduction in both the speed and directionality of migration of prostate cancer cells, which is consistent with an observed loss of expression of TCAF1 in metastatic human specimens, whereas TCAF2 promotes migration. The identification of TCAFs introduces a novel mechanism for modulation of TRPM8 channel activity.

scholarly journals The effect of the electrophilic fatty acid nitro-oleic acid on TRP channel function in sensory neurons

Nitric Oxide ◽  
2018 ◽  
Vol 78 ◽  
pp. 154-160 ◽  
Author(s):  
Jonathan M. Beckel ◽  
William C. de Groat
Keyword(s):  
Oleic Acid ◽  
Fatty Acid ◽  
Sensory Neurons ◽  
Trp Channel ◽  
Channel Function

scholarly journals TRP Channel Function in iPSC-Derived Sensory Neurons

2017 ◽  
Vol 112 (3) ◽  
pp. 135a
Author(s):  
Laura Vangeel
Keyword(s):  
Sensory Neurons ◽  
Trp Channel ◽  
Channel Function

scholarly journals Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal

2021 ◽  
Vol 22 (2) ◽  
pp. 481
Author(s):  
Fernando Aleixandre-Carrera ◽  
Nurit Engelmayer ◽  
David Ares-Suárez ◽  
María del Carmen Acosta ◽  
Carlos Belmonte ◽  
...  
Keyword(s):  
Nerve Terminal ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Functional Organization ◽  
Receptor Potential ◽  
Sensory Transduction ◽  
Trp Channel ◽  
Optical Methods ◽  
Channel Function

Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation of ion channel activity by pharmacological tools has provided an invaluable opportunity to directly assess nociceptive TRP channel function at the nerve terminal.

Proteins modulating TRP channel function

Cell Calcium ◽  
2003 ◽  
Vol 33 (5-6) ◽  
pp. 303-310 ◽  
Author(s):  
Christian Harteneck
Keyword(s):  
Trp Channel ◽  
Channel Function

GLP-1 based multi-agonists-induced signaling includes profound TRP channel involvement in insulin secretion

2017 ◽  
Author(s):  
Noushafarin Khajavi ◽  
Brian Finan ◽  
Oliver Kluth ◽  
Stefan Mergler ◽  
Timo Muller ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Trp Channel
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