Evaluating B-Cells: From Bone Marrow Precursors to Antibody-Producing Cells

2013 ◽  
pp. 45-57 ◽  
Author(s):  
M. Manuela Rosado ◽  
Marco Scarsella ◽  
Simona Cascioli ◽  
Ezio Giorda ◽  
Rita Carsetti
Keyword(s):  
Bone Marrow ◽  
B Cells

scholarly journals IL-7R signaling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells

Cell Reports ◽  
2021 ◽  
Vol 36 (2) ◽  
pp. 109349
Author(s):  
Amanda Baizan-Edge ◽  
Bryony A. Stubbs ◽  
Michael J.T. Stubbington ◽  
Daniel J. Bolland ◽  
Kristina Tabbada ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Antibody Diversity ◽  
Gene Usage

scholarly journals A comparative analysis of human bone marrow–resident and peripheral memory B cells

2018 ◽  
Vol 141 (5) ◽  
pp. 1911-1913.e7 ◽  
Author(s):  
Sonya C. Becker ◽  
Martin Szyska ◽  
Angela Mensen ◽  
Katharina Hellwig ◽  
Raik Otto ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Comparative Analysis ◽  
B Cells ◽  
Memory B Cells ◽  
Human Bone ◽  
Human Bone Marrow

scholarly journals INDUCTION OF A HEMOLYSIN RESPONSE IN VITRO

1971 ◽  
Vol 133 (6) ◽  
pp. 1325-1333 ◽  
Author(s):  
Klaus-Ulrich Hartmann
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
B Cells ◽  
Close Contact ◽  
Precursor Cells ◽  
Spleen Cells ◽  
High Concentrations ◽  
Thymus Cells ◽  
Bone Marrow Chimeras

Spleen cells of bone marrow chimeras (B cells) and of irradiated mice injected with thymus cells and heterologous erythrocytes (educated T cells) were mixed and cultured together (17). The number of PFC developing in these cultures was dependent both on the concentration of the B cells and of the educated T cells. In excess of T cells the number of developing PFC is linearly dependent on the number of B cells. At high concentrations of T cells more PFC developed; the increase in the number of PFC was greatest between the 3rd and 4th day of culture. Increased numbers of educated T cells also assisted the development of PFC directed against the erythrocytes. It is concluded that the T cells not only play a role during the triggering of the precursor cells but also during the time of proliferation of the B cells; close contact between B and T cells seems to be needed to allow the positive activity of the T cells.

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

Cell ◽  
1994 ◽  
Vol 77 (1) ◽  
pp. 133-143 ◽  
Author(s):  
Hajime Karasuyama ◽  
Antonius Rolink ◽  
Yoichi Shinkal ◽  
Faith Young ◽  
Frederick W. Alt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
B Cell ◽  
Light Chain ◽  
Mutant Mice ◽  
Deficient Mutant ◽  
Surrogate Light Chain ◽  
Bone Marrow Precursor ◽  
Precursor B Cells

Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages

1990 ◽  
Vol 10 (7) ◽  
pp. 3562-3568
Author(s):  
M Principato ◽  
J L Cleveland ◽  
U R Rapp ◽  
K L Holmes ◽  
J H Pierce ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
B Cell ◽  
Cell Lines ◽  
Bone Marrow Cells ◽  
Hematopoietic Differentiation ◽  
Developmental Relationships ◽  
Murine Bone Marrow ◽  
B Lineage ◽  
Marrow Cells

Murine bone marrow cells infected with replication-defective retroviruses containing v-raf alone or v-myc alone yielded transformed pre-B cell lines, while a retroviral construct containing both v-raf and v-myc oncogenes produced clonally related populations of mature B cells and mature macrophages. The genealogy of these transformants demonstrates that mature myeloid cells were derived from cells with apparent B-lineage commitment and functional immunoglobulin rearrangements. This system should facilitate studies of developmental relationships in hematopoietic differentiation and analysis of lineage determination.

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