Human Umbilical Cord Blood Cells for Stroke

2010 ◽  
pp. 155-167 ◽  
Author(s):  
Dong-Hyuk Park ◽  
Alison E. Willing ◽  
Cesar V. Borlongan ◽  
Tracy A. Womble ◽  
L. Eduardo Cruz ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration

2010 ◽  
Vol 5 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Antonio Herranz ◽  
Rafael Gonzalo-Gobernado ◽  
Diana Reimers ◽  
Maria Asensio ◽  
Macarena Rodriguez-Serrano ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

scholarly journals Human Umbilical Cord Blood Cells Restore Brain Damage Induced Changes in Rat Somatosensory Cortex

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20194 ◽  
Author(s):  
Maren Geißler ◽  
Hubert R. Dinse ◽  
Sandra Neuhoff ◽  
Klaus Kreikemeier ◽  
Carola Meier
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells ◽  
Rat Somatosensory Cortex ◽  
Induced Changes

scholarly journals Human Umbilical Cord Blood Cells Decrease Microglial Survival In Vitro

2010 ◽  
Vol 19 (2) ◽  
pp. 221-228 ◽  
Author(s):  
Lixian Jiang ◽  
Tracy Womble ◽  
Samuel Saporta ◽  
Ning Chen ◽  
Cyndy Davis Sanberg ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

Engraftment of freshly isolated or cultured human umbilical cord blood cells and the effect of cyclosporin A on the outcome

2005 ◽  
Vol 192 (2) ◽  
pp. 365-372 ◽  
Author(s):  
Yi Pan ◽  
Jay B. Nastav ◽  
Haibo Zhang ◽  
Randolph H. Bretton ◽  
W. Michael Panneton ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

scholarly journals Human Umbilical Cord Blood Cells Ameliorate Motor Deficits in Rabbits in a Cerebral Palsy Model

2015 ◽  
Vol 37 (4-5) ◽  
pp. 349-362 ◽  
Author(s):  
Alexander Drobyshevsky ◽  
C. Michael Cotten ◽  
Zhongjie Shi ◽  
Kehuan Luo ◽  
Rugang Jiang ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
High Dose ◽  
Human Umbilical Cord ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

Cerebral palsy (CP) has a significant impact on both patients and society, but therapy is limited. Human umbilical cord blood cells (HUCBC), containing various stem and progenitor cells, have been used to treat various brain genetic conditions. In small animal experiments, HUCBC have improved outcomes after hypoxic-ischemic (HI) injury. Clinical trials using HUCBC are underway, testing feasibility, safety and efficacy for neonatal injury as well as CP. We tested HUCBC therapy in a validated rabbit model of CP after acute changes secondary to HI injury had subsided. Following uterine ischemia at 70% gestation, we infused HUCBC into newborn rabbit kits with either mild or severe neurobehavioral changes. Infusion of high-dose HUCBC (5 × 106 cells) dramatically altered the natural history of the injury, alleviating the abnormal phenotype including posture, righting reflex, locomotion, tone, and dystonia. Half the high dose showed lesser but still significant improvement. The swimming test, however, showed that joint function did not restore to naïve control function in either group. Tracing HUCBC with either MRI biomarkers or PCR for human DNA found little penetration of HUCBC in the newborn brain in the immediate newborn period, suggesting that the beneficial effects were not due to cellular integration or direct proliferative effects but rather to paracrine signaling. This is the first study to show that HUCBC improve motor performance in a dose-dependent manner, perhaps by improving compensatory repair processes.

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