Predicting Nucleus Basalis of Meynert Volume from Compartmental Brain Segmentations

2018 ◽  
pp. 68-75 ◽  
Author(s):  
Hennadii Madan ◽  
Rok Berlot ◽  
Nicola J. Ray ◽  
Franjo Pernuš ◽  
Žiga Špiclin
Keyword(s):  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

scholarly journals In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies

2021 ◽  
Vol 30 ◽  
pp. 102604
Author(s):  
Julia Schumacher ◽  
John-Paul Taylor ◽  
Calum A. Hamilton ◽  
Michael Firbank ◽  
Ruth A. Cromarty ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Lewy Bodies ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

scholarly journals Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease

2021 ◽  
pp. 1-6
Author(s):  
Julia Schumacher ◽  
Alan J. Thomas ◽  
Luis R. Peraza ◽  
Michael Firbank ◽  
John T. O’Brien ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Lewy Body ◽  
Cholinergic System ◽  
Structural Changes ◽  
Lewy Body Dementia ◽  
Occipital Cortex ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

ABSTRACT Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.

scholarly journals Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Muhammad Nazmuddin ◽  
Ingrid H. C. H. M. Philippens ◽  
Teus van Laar
Keyword(s):  
Electrical Stimulation ◽  
Clinical Data ◽  
Animal Studies ◽  
Receptive Fields ◽  
Lewy Body Dementia ◽  
Clinical Situation ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Clinical Effects ◽  
Stimulation Of

AbstractDeep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically investigated in Alzheimer’s disease (AD) and Lewy body dementia (LBD). However, the clinical effects are highly variable, which questions the suggested basic principles underlying these clinical trials. Therefore, preclinical and clinical data on the design of NBM stimulation experiments and its effects on behavioral and neurophysiological aspects are systematically reviewed here. Animal studies have shown that electrical stimulation of the NBM enhanced cognition, increased the release of acetylcholine, enhanced cerebral blood flow, released several neuroprotective factors, and facilitates plasticity of cortical and subcortical receptive fields. However, the translation of these outcomes to current clinical practice is hampered by the fact that mainly animals with an intact NBM were used, whereas most animals were stimulated unilaterally, with different stimulation paradigms for only restricted timeframes. Future animal research has to refine the NBM stimulation methods, using partially lesioned NBM nuclei, to better resemble the clinical situation in AD, and LBD. More preclinical data on the effect of stimulation of lesioned NBM should be present, before DBS of the NBM in human is explored further.

PS-46-4 The effects of nucleus basalis of meynert lesions on the P-3 like potentials in rabbits

1995 ◽  
Vol 97 (4) ◽  
pp. S205
Author(s):  
Yuping Wang ◽  
Kenji Nakashima ◽  
Yasuaki Kawai ◽  
Eisaku Ohama ◽  
Kazuro Takahashi
Keyword(s):  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert
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