Omics: Potential Role in Early Phase Drug Development

2019 ◽  
pp. 309-347
Author(s):  
Harald Grallert ◽  
Carola S. Marzi ◽  
Stefanie M. Hauck ◽  
Christian Gieger
Keyword(s):  
Drug Development ◽  
Early Phase ◽  
Potential Role

Omics: Potential Role in Early-Phase Drug Development

2014 ◽  
pp. 189-222
Author(s):  
Harald Grallert ◽  
Carola S. Marzi ◽  
Stefanie M. Hauck ◽  
Christian Gieger
Keyword(s):  
Drug Development ◽  
Early Phase ◽  
Potential Role

Diosgenin: Therapeutic Action, Pharmacology and Applications

2017 ◽  
Vol 5 (1) ◽  
pp. 7-15
Author(s):  
Sanasam Sanjeev ◽  
◽  
Maibam Sunita Devi ◽  
Khushboo Maurya ◽  
Vikas Kumar Roy ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Drug Development ◽  
Liver Diseases ◽  
Potential Role ◽  
Wide Spectrum ◽  
Herbal Product ◽  
Biological Properties ◽  
Therapeutic Action ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Beneficial Effects

Diosgenin [25R-spriost-5-en-3þ-ol], is an important steroidal metabolite found in various plant species. The discovery of diosgenin has made it one of the most researched and studied herbal product. Moreover, there is excellent opportunity to address whether diosgenin plays a role in chemoprevention versus therapy, or both. However, rigorous experimental based evidence in support of ethnomedicine-derived notions would lead to the development of products relevant to drug development. The health beneficial effects of diosgenin are further extended to its potential role to treat other ailments such as HIV and hepatitis-C infections as well as liver diseases. There is little information regarding the bioavailability, pharmacokinetics and pharmacodynamics of diosgenin in relation to its health beneficial effects. It has been reported to have wide spectrum of biological properties that contributes to several diseases in its role as a health beneficial phytochemical by citing new studies.

scholarly journals Principal stratum strategy: Potential role in drug development

2021 ◽  
Author(s):  
Björn Bornkamp ◽  
Kaspar Rufibach ◽  
Jianchang Lin ◽  
Yi Liu ◽  
Devan V. Mehrotra ◽  
...  
Keyword(s):  
Drug Development ◽  
Potential Role

Early phase drug development for treatment of chronic pain — Options for clinical trial and program design

2012 ◽  
Vol 33 (4) ◽  
pp. 689-699 ◽  
Author(s):  
Jarkko Kalliomäki ◽  
Frank Miller ◽  
Matts Kågedal ◽  
Rolf Karlsten
Keyword(s):  
Clinical Trial ◽  
Chronic Pain ◽  
Drug Development ◽  
Early Phase ◽  
Program Design

Hepatitis C virus replicons: potential role for drug development

2002 ◽  
Vol 1 (11) ◽  
pp. 911-916 ◽  
Author(s):  
Ralf Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Development ◽  
Potential Role

Efficient Design of Integrated and Adaptively Interlinked Protocols for Early-Phase Drug Development Programs

2019 ◽  
pp. 216847901882108
Author(s):  
Simon Coates ◽  
Oliver Pohl ◽  
Jean-Pierre Gotteland ◽  
Jörg Täubel ◽  
Ulrike Lorch
Keyword(s):  
Drug Development ◽  
Early Phase ◽  
Development Programs ◽  
Efficient Design
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