Using Random Forest Classifier for Particle Identification in the ALICE Experiment

2019 ◽  
pp. 3-17 ◽  
Author(s):  
Tomasz Trzciński ◽  
◽  
Łukasz Graczykowski ◽  
Michał Glinka
Keyword(s):  
Random Forest ◽  
Random Forest Classifier ◽  
Particle Identification ◽  
Alice Experiment

The Performance Improvement on 4-FB Face using Random Forest Classifier

2018 ◽  
Vol 10 (5) ◽  
pp. 1-12
Author(s):  
B. Nassih ◽  
A. Amine ◽  
M. Ngadi ◽  
D. Naji ◽  
N. Hmina
Keyword(s):  
Random Forest ◽  
Performance Improvement ◽  
Random Forest Classifier

Methodology for Malware Classification using a Random Forest Classifier

2018 ◽  
Author(s):  
Carlos Domenick Morales-Molina ◽  
Diego Santamaria-Guerrero ◽  
Gabriel Sanchez-Perez ◽  
Hector Perez-Meana ◽  
Aldo Hernandez-Suarez
Keyword(s):  
Random Forest ◽  
Random Forest Classifier ◽  
Malware Classification

scholarly journals Amide proton transfer weighted (APTw) imaging based radiomics allows for the differentiation of gliomas from metastases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elisabeth Sartoretti ◽  
Thomas Sartoretti ◽  
Michael Wyss ◽  
Carolin Reischauer ◽  
Luuk van Smoorenburg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Brain Tumors ◽  
Proton Transfer ◽  
Multilayer Perceptron ◽  
Random Forest Classifier ◽  
Amide Proton ◽  
Low Grade ◽  
Who Grade ◽  
Amide Proton Transfer

AbstractWe sought to evaluate the utility of radiomics for Amide Proton Transfer weighted (APTw) imaging by assessing its value in differentiating brain metastases from high- and low grade glial brain tumors. We retrospectively identified 48 treatment-naïve patients (10 WHO grade 2, 1 WHO grade 3, 10 WHO grade 4 primary glial brain tumors and 27 metastases) with either primary glial brain tumors or metastases who had undergone APTw MR imaging. After image analysis with radiomics feature extraction and post-processing, machine learning algorithms (multilayer perceptron machine learning algorithm; random forest classifier) with stratified tenfold cross validation were trained on features and were used to differentiate the brain neoplasms. The multilayer perceptron achieved an AUC of 0.836 (receiver operating characteristic curve) in differentiating primary glial brain tumors from metastases. The random forest classifier achieved an AUC of 0.868 in differentiating WHO grade 4 from WHO grade 2/3 primary glial brain tumors. For the differentiation of WHO grade 4 tumors from grade 2/3 tumors and metastases an average AUC of 0.797 was achieved. Our results indicate that the use of radiomics for APTw imaging is feasible and the differentiation of primary glial brain tumors from metastases is achievable with a high degree of accuracy.

scholarly journals Fully automated analysis combining [18F]-FET-PET and multiparametric MRI including DSC perfusion and APTw imaging: a promising tool for objective evaluation of glioma progression

2021 ◽  
Author(s):  
K. J. Paprottka ◽  
S. Kleiner ◽  
C. Preibisch ◽  
F. Kofler ◽  
F. Schmidt-Graf ◽  
...  
Keyword(s):  
Random Forest ◽  
Tumor Progression ◽  
Automated Analysis ◽  
Random Forest Classifier ◽  
Imaging Modalities ◽  
Amide Proton ◽  
Tumor Board ◽  
Dynamic Susceptibility ◽  
Fet Pet ◽  
Promising Tool

Abstract Purpose To evaluate diagnostic accuracy of fully automated analysis of multimodal imaging data using [18F]-FET-PET and MRI (including amide proton transfer-weighted (APTw) imaging and dynamic-susceptibility-contrast (DSC) perfusion) in differentiation of tumor progression from treatment-related changes in patients with glioma. Material and methods At suspected tumor progression, MRI and [18F]-FET-PET data as part of a retrospective analysis of an observational cohort of 66 patients/74 scans (51 glioblastoma and 23 lower-grade-glioma, 8 patients included at two different time points) were automatically segmented into necrosis, FLAIR-hyperintense, and contrast-enhancing areas using an ensemble of deep learning algorithms. In parallel, previous MR exam was processed in a similar way to subtract preexisting tumor areas and focus on progressive tumor only. Within these progressive areas, intensity statistics were automatically extracted from [18F]-FET-PET, APTw, and DSC-derived cerebral-blood-volume (CBV) maps and used to train a Random Forest classifier with threefold cross-validation. To evaluate contribution of the imaging modalities to the classifier’s performance, impurity-based importance measures were collected. Classifier performance was compared with radiology reports and interdisciplinary tumor board assessments. Results In 57/74 cases (77%), tumor progression was confirmed histopathologically (39 cases) or via follow-up imaging (18 cases), while remaining 17 cases were diagnosed as treatment-related changes. The classification accuracy of the Random Forest classifier was 0.86, 95% CI 0.77–0.93 (sensitivity 0.91, 95% CI 0.81–0.97; specificity 0.71, 95% CI 0.44–0.9), significantly above the no-information rate of 0.77 (p = 0.03), and higher compared to an accuracy of 0.82 for MRI (95% CI 0.72–0.9), 0.81 for [18F]-FET-PET (95% CI 0.7–0.89), and 0.81 for expert consensus (95% CI 0.7–0.89), although these differences were not statistically significant (p > 0.1 for all comparisons, McNemar test). [18F]-FET-PET hot-spot volume was single-most important variable, with relevant contribution from all imaging modalities. Conclusion Automated, joint image analysis of [18F]-FET-PET and advanced MR imaging techniques APTw and DSC perfusion is a promising tool for objective response assessment in gliomas.

scholarly journals A random forest classifier predicts recurrence risk in patients with ovarian cancer

2018 ◽  
Author(s):  
Li Cheng ◽  
Lin Li ◽  
Liling Wang ◽  
Xiaofang Li ◽  
Hui Xing ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Random Forest ◽  
Recurrence Risk ◽  
Random Forest Classifier

MSIFinder: A python package for detecting MSI status using random forest classifier.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 2601-2601
Author(s):  
Tao Zhou ◽  
Libin Chen ◽  
Jing Guo ◽  
Mengmeng Zhang ◽  
Huanhuan Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Random Forest ◽  
Microsatellite Instability ◽  
Random Forest Classifier ◽  
Sequencing Depth ◽  
Genomic Alteration ◽  
Test Set ◽  
Panel Size ◽  
Python Package ◽  
Training Sets

2601 Background: Microsatellite instability (MSI) is a common genomic alteration in several tumors, such as colorectal cancer, endometrial carcinoma, and stomach, which is characterized as microsatellite instability-high (MSI-H) and microsatellite stable (MSS) based on a high degree of polymorphism in microsatellite lengths. MSI is a predictive biomarker for immunotherapy efficacy in advanced/metastatic solid tumors, especially in colorectal cancer (CRC) patients. Several computational approaches based on target panel sequencing data have been used to detect MSI; However, they are considerably affected by the sequencing depth and panel size. Methods: We developed MSIFinder, a python package for automatic MSI classification, using random forest classifier (RFC)-based genome sequencing, which is a machine learning technology. We included 19 MSI-H and 25 MSS samples as training sets. First, RFC model were built by 54 feature markers from the training sets. Second. The software was validated the classifier using a test set comprising 21 MSI-H and 379 MSS samples. Results: With this test set, MSIFinder achieved a sensitivity (recall) of 0.997, a specificity of 1, an accuracy of 0.998, a positive predictive value (PPV) of 0.954, an F1 score of 0.977, and an area under curve (AUC) of 0.999. We discovered that MSIFinder is less affected by low sequencing depth and can achieve a concordance of 0.993, while exhibiting a sequencing depth of 100×. Furthermore, we realized that MSIFinder is less affected by the panel size and can achieve a concordance of 0.99 when the panel size is 0.5 m (million base). Conclusions: These results indicated that MSIFinder is a robust MSI classification tool and not affected by the panel size and sequencing depth. Furthermore, MSIFinder can provide reliable MSI detection for scientific and clinical purposes.[Table: see text]

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