Position and Deformation-Checking Method Based on Structured Illumination. External Radiotherapy Use

Summary Purpose: Despite highly efficacious chemotherapy, patients with osteosarcomas still have a poor prognosis if adequate surgical control cannot be obtained. These patients may benefit from therapy with radiolabeled phosphonates. Patients and Methods: Six patients (three male, three female; seven to 41 years) with unresectable primary osteosarcoma (n = 3) or unresectable recurrent sites of osteosarcomas (n = 3) were treated with high-activity of Sm-153-EDTMP (150 MBq/kg BW). In all patients autologous peripheral blood stem cells had been collected before Sm-153-EDTMP therapy. Results: No immediate adverse reactions were observed in the patients. In one patient bone pain increased during the first 48 hrs after therapy. Three patients received pain relief. Autologous peripheral blood stem cell reinfusion was performed on day +12 to +27 in all patients to overcome potentially irreversible damage to the hematopoietic stem cells. In three patient external radiotherapy of the primary tumor site was performed after Sm-153-EDTMP therapy and in two of them polychemotherapy was continued. Thirty-six months later one of these patients is still free of progression. Two further patients are still alive. However, they have developed new metastases. The three patients who had no accompanying external radiotherapy, all died of disease progression five to 20 months after therapy. Conclusion: These preliminary results show that high-dose Sm-153-EDTMP therapy is feasible and warrants further evaluation of efficacy. The combination with external radiation and polychemotherapy seems to be most promising. Although osteosarcoma is believed to be relatively radioresistant, the total focal dose achieved may delay local progression or even achieve permanent local tumor control in patients with surgically inaccessible primary or relapsing tumors.

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MULTIPLE SCATTERING SUPPRESSION IN PLANAR LASER IMAGING OF DENSE SPRAYS BY MEANS OF STRUCTURED ILLUMINATION

Atomization and Sprays ◽

10.1615/atomizspr.v20.i2.30 ◽

2010 ◽

Vol 20 (2) ◽

pp. 133-139 ◽

Cited By ~ 8

Author(s):

Edouard Berrocal ◽

Elias Kristensson ◽

Mattias Richter ◽

Mark Linne ◽

Marcus Alden

Keyword(s):

Multiple Scattering ◽

Structured Illumination ◽

Laser Imaging ◽

Planar Laser

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High Speed Fluorescence Endomicroscopy with Structured Illumination for Robot Assisted Minimally Invasive Surgery

10.31256/hsmr2018.19 ◽

2018 ◽

Author(s):

Haojie Zhang ◽

◽

Guang-Zhong Yang

Keyword(s):

Minimally Invasive Surgery ◽

Minimally Invasive ◽

Invasive Surgery ◽

High Speed ◽

Structured Illumination ◽

Robot Assisted

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Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

Journal of Biomedical Physics and Engineering ◽

10.31661/jbpe.v9i2apr.827 ◽

2019 ◽

Vol 9 (2Apr) ◽

Cited By ~ 1

Author(s):

S Farahani ◽

N Riyahi Alam ◽

S Haghgoo ◽

M Khoobi ◽

Gh Geraily ◽

...

Keyword(s):

Gold Nanoparticles ◽

3D Visualization ◽

Energy Levels ◽

Polymer Gel ◽

External Radiotherapy ◽

Dose Enhancement ◽

Internal Radiotherapy ◽

Boost Radiotherapy

Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lying tumors require much higher energy levels with greater penetration power, and investigations carried out in megavoltage energy range show contradictory results.Objective: In this study, we quantitatively assess and compare dose enhancement factors (DEFs) obtained through AuNPs under radiation of Cobalt-60 source (1.25MeV) versus Iridium-192 source (0.380 KeV) using MAGAT gel dosimeter.Material and Methods: MAGAT polymer gel in both pure and combined with 0.2 mM AuNPs was synthesized. In order to quantify the effect of energy on DEF, irradiation was carried out by Co-60 external radiotherapy and Ir-192 internal radiotherapy. Finally, readings of irradiated and non-irradiated gels were performed by MR imaging.Result: The radiation-induced R2 (1/T2) changes of the gel tubes doped with AuNPs compared to control samples, upon irradiation of beams released by Ir-192 source showed a significant dose enhancement (15.31% ±0.30) relative to the Co-60 external radiotherapy (5.85% ±0.14).Conclusion: This preliminary study suggests the feasibility of using AuNPs in radiation therapy (RT), especially in low-energy sources of brachytherapy. In addition, MAGAT polymer gel, as a powerful dosimeter, could be used for 3D visualization of radiation dose distribution of AuNPs in radiotherapy.

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