A Risk-Structured Mathematical Model of Buruli Ulcer Disease in Ghana

2019 ◽  
pp. 109-128 ◽  
Author(s):  
Christina Edholm ◽  
Benjamin Levy ◽  
Ash Abebe ◽  
Theresia Marijani ◽  
Scott Le Fevre ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Buruli Ulcer ◽  
Ulcer Disease

scholarly journals Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease

2008 ◽  
Vol 14 (8) ◽  
pp. 1247-1254 ◽  
Author(s):  
M. Eric Benbow ◽  
Heather Williamson ◽  
Ryan Kimbirauskas ◽  
Mollie D. McIntosh ◽  
Rebecca Kolar ◽  
...  
Keyword(s):  
Aquatic Invertebrates ◽  
Buruli Ulcer ◽  
Ulcer Disease

scholarly journals Buruli-Ulcer Induced Disability in Ghana: A Study at Apromase in the Ashanti Region

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Pius Agbenorku ◽  
Anthony Edusei ◽  
Margaret Agbenorku ◽  
Thomas Diby ◽  
Esenam Nyador ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Buruli Ulcer ◽  
Lower Limbs ◽  
Daily Activities ◽  
Ulcer Disease ◽  
Mission Hospital ◽  
Ankle Joints ◽  
Proportional Increase ◽  
Using Data ◽  
Set Up

Objectives. To describe trends and category of disabilities caused by Buruli ulcer disease. Design. This retrospective study was set up to quantify information on the disability trends caused by Buruli ulcer (BU) using data on patients attending BU and chronic ulcer clinics from 2004 to 2009, at Global Evangelical Mission Hospital, Apromase. Methods. Data was retrieved from the WHO BU1 form, case registry book, surgical theatre register, and BU patients' records book of the hospital. Disability was measured as the incapability of patients to perform one or more daily activities due to his/her state of BU disease before treatment. Results. A total of 336 positive BU cases comprising 181 males (53.9%) were recorded of which 113 (33.6%) cases of disabilities were identified. A mean age of 52.5 (±1.32) years was recorded. For the trend of disabilities, the year 2009 recorded the highest (N = 34, 31.0%). The lesions were mostly located at the lower limbs (N = 65, 57.5%) region of the patients. Lesions with diameter >15 cm were the major (59.3%) category of lesions. Conclusion. Trend of disability reveals proportional increase over the years from 2004 to 2009. Contracture at the knee and ankle joints was the commonest disability recorded.

scholarly journals Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone

2021 ◽  
Vol 12 ◽  
Author(s):  
Bruno Tello Rubio ◽  
Florence Bugault ◽  
Blandine Baudon ◽  
Bertrand Raynal ◽  
Sébastien Brûlé ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Molecular Mechanisms ◽  
Scavenger Receptor ◽  
Buruli Ulcer ◽  
Systemic Circulation ◽  
Mycobacterium Ulcerans ◽  
Host Cells ◽  
Ulcer Disease ◽  
Major Mechanism ◽  
Specific Association

Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of Buruli ulcer disease. Altough bacterially derived mycolactone has been shown to traffic from cutaneous foci of infection to the bloodstream, the mechanisms underpinning its access to systemic circulation and import by host cells remain largely unknown. Using biophysical and cell-based approaches, we demonstrate that mycolactone specific association to serum albumin and lipoproteins is necessary for its solubilization and is a major mechanism to regulate its bioavailability. We also demonstrate that Scavenger Receptor (SR)-B1 contributes to the cellular uptake of mycolactone. Overall, we suggest a new mechanism of transport and cell entry, challenging the dogma that the toxin enters host cells via passive diffusion.

scholarly journals A stepwise approach to the laboratory diagnosis of Buruli ulcer disease

2006 ◽  
Vol 0 (0) ◽  
pp. 061109085615002-??? ◽  
Author(s):  
G. Bretzel ◽  
V. Siegmund ◽  
J. Nitschke ◽  
K. H. Herbinger ◽  
W. Thompson ◽  
...  
Keyword(s):  
Buruli Ulcer ◽  
Laboratory Diagnosis ◽  
Stepwise Approach ◽  
Ulcer Disease

scholarly journals Aquatic Snails, Passive Hosts of Mycobacterium ulcerans

2004 ◽  
Vol 70 (10) ◽  
pp. 6296-6298 ◽  
Author(s):  
Laurent Marsollier ◽  
Tchibozo Sévérin ◽  
Jacques Aubry ◽  
Richard W. Merritt ◽  
Jean-Paul Saint André ◽  
...  
Keyword(s):  
Buruli Ulcer ◽  
Indirect Evidence ◽  
Mycobacterium Ulcerans ◽  
Aquatic Environments ◽  
Potential Vector ◽  
Ulcer Disease ◽  
Skin Ulcers ◽  
Chronic Skin ◽  
Favorable Conditions ◽  
Water Bugs

ABSTRACT Accumulative indirect evidence of the epidemiology of Mycobacterium ulcerans infections causing chronic skin ulcers (i.e., Buruli ulcer disease) suggests that the development of this pathogen and its transmission to humans are related predominantly to aquatic environments. We report that snails could transitorily harbor M. ulcerans without offering favorable conditions for its growth and replication. A novel intermediate link in the transmission chain of M. ulcerans becomes likely with predator aquatic insects in addition to phytophage insects. Water bugs, such as Naucoris cimicoides, a potential vector of M. ulcerans, were shown to be infected specifically by this bacterium after feeding on snails experimentally exposed to M. ulcerans.

scholarly journals Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

2018 ◽  
Vol 110 (11) ◽  
pp. 237-248 ◽  
Author(s):  
Caroline Demangel ◽  
Stephen High
Keyword(s):  
Buruli Ulcer ◽  
Central Mechanism ◽  
Ulcer Disease

scholarly journals Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

2014 ◽  
Vol 8 (4) ◽  
pp. e2786 ◽  
Author(s):  
Richard O. Phillips ◽  
Fred S. Sarfo ◽  
Jordi Landier ◽  
Reid Oldenburg ◽  
Michael Frimpong ◽  
...  
Keyword(s):  
Serum Protein ◽  
Buruli Ulcer ◽  
Ulcer Disease ◽  
Protein Levels ◽  
Metabolic Defects

scholarly journals Buruli ulcer disease prevalence in Benin, West Africa: associations with land use/cover and the identification of disease clusters

2008 ◽  
Vol 7 (1) ◽  
pp. 25 ◽  
Author(s):  
Tyler Wagner ◽  
M Eric Benbow ◽  
Travis O Brenden ◽  
Jiaguo Qi ◽  
R Christian Johnson
Keyword(s):  
Land Use ◽  
West Africa ◽  
Buruli Ulcer ◽  
Disease Prevalence ◽  
Disease Clusters ◽  
Ulcer Disease
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