Qualitative Analysis of a PDE Model of Telomere Loss in a Proliferating Cell Population in the Light of Suns and Stars

2019 ◽  
pp. 71-85
Author(s):  
Y. Elalaoui ◽  
L. Alaoui
Keyword(s):  
Qualitative Analysis ◽  
Cell Population ◽  
Pde Model ◽  
Telomere Loss ◽  
Proliferating Cell

scholarly journals 5-AMINOURACIL TREATMENT

1971 ◽  
Vol 48 (2) ◽  
pp. 248-252 ◽  
Author(s):  
S. H. Socher ◽  
D. Davidson
Keyword(s):  
Mitotic Index ◽  
Vicia Faba ◽  
Cell Population ◽  
Lateral Roots ◽  
Proliferating Cells ◽  
Dividing Cells ◽  
Proliferating Cell ◽  
Two Populations

Treatment of Vicia faba lateral roots with a range of concentrations of 5-aminouracil (5-AU) indicate that cells are stopped at a particular point in interphase. The timing of the fall in mitotic index suggests that cells are held at the S - G2 transition. When cells are held at this point, treatments with 5-AU can be used to estimate the duration of G2 + mitosis/2 of proliferating cells. Treatment with 5-AU can also be used to demonstrate the presence of subpopulations of dividing cells that differ in their G2 duration. Using this method, 5-AU-induced inhibition, we have confirmed that in V. faba lateral roots there are two populations of dividing cells: (a) a fast-dividing population, which makes up ∼85% of the proliferating cell population and has a G2 + mitosis/2 duration of 3.3 hr, and (b) a slow-dividing population, which makes up ∼15% of dividing cells and has a G2 duration in excess of 12 hr. These estimates are similar to those obtained from percentage labeled mitosis (PLM) curves after incorporation of thymidine-3H.

Anaplasia and Heterogeneity of Gfap Expression in Gliomas

1986 ◽  
Vol 72 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Davide Schiffer ◽  
Maria Teresa Giordana ◽  
Isabella Germano ◽  
Alessandro Mauro
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Tumor Cells ◽  
Cell Population ◽  
Malignant Gliomas ◽  
Reactive Astrocytes ◽  
Mutation Rates ◽  
Protein Distribution ◽  
Gfap Expression ◽  
Proliferating Cell ◽  
Negative Population

GFAP (glial fibrillary acidic protein) distribution was investigated in selected areas of glioblastomas and astrocytomas. The proliferating cell population of glioblastomas was GFAP negative and contained many mitoses which were also negative. The old, deeply located areas were composed of cells with visible cytoplasm, intensely GFAP-positive; mitoses in these areas were both GFAP-positive and negative. GFAP-positive reactive astrocytes, once trapped in the tumor, were no longer distinguishable from positive tumor cells. They sometimes contained mitoses. In astrocytoma, anaplasia was due to the development of a GFAP-negative population with negative mitoses. The problem of dedifferentiation and differentiation of malignant gliomas in discussed taking into account the possiblity that malignancy may be due to increasing mutation rates of tumors. The problem of redifferentiation of already dedifferentiated cells is also discussed.

Basal-like Cells Constitute the Proliferating Cell Population in Cystic Fibrosis Airways

2005 ◽  
Vol 172 (8) ◽  
pp. 1013-1018 ◽  
Author(s):  
Judith A. Voynow ◽  
Bernard M. Fischer ◽  
Bruce C. Roberts ◽  
Alan D. Proia
Keyword(s):  
Cystic Fibrosis ◽  
Cell Population ◽  
Proliferating Cell
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