Early Stage Squamous Cell Lung Cancer Detection

Before squamous cell lung cancer develops, pre-cancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such lesions become cancer, whereas a third spontaneously regress. While recent studies have described the presence of an active immune response in high-grade lesions, the mechanisms underpinning clinical regression of pre-cancerous lesions remain unknown. Here, we show that host immune surveillance is strongly implicated in lesion regression. Using bronchoscopic biopsies from human subjects, we find that regressive carcinoma in-situ lesions harbour more infiltrating immune cells than those that progress to cancer. Moreover, molecular profiling of these lesions identifies potential immune escape mechanisms specifically in those that progress to cancer: antigen presentation is impaired by genomic and epigenetic changes, TGF-beta signalling is overactive, and the immunomodulator TNFSF9 is downregulated. Changes appear intrinsic to the CIS lesions as the adjacent stroma of progressive and regressive lesions are transcriptomically similar. This study identifies mechanisms by which pre-cancerous lesions evade immune detection during the earliest stages of carcinogenesis and forms a basis for new therapeutic strategies that treat or prevent early stage lung cancer.

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P3.05-007 Potential of CYFRA 21-1 and CEA to Predict Adjuvant Chemotherapy Benefit in Early-Stage Squamous Cell Lung Cancer

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2017.09.1678 ◽

2017 ◽

Vol 12 (11) ◽

pp. S2292-S2293

Author(s):

T. Muley ◽

V. Rolny ◽

Y. He ◽

B. Wehnl ◽

A. Escherich ◽

...

Keyword(s):

Lung Cancer ◽

Adjuvant Chemotherapy ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Early Stage ◽

Squamous Cell Lung Cancer

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Prognostic value of three microRNA expression profiles in early-stage squamous cell lung cancer (SqCLC).

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.7028 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. 7028-7028

Author(s):

M. T. Skrzypski ◽

A. Szymanowska ◽

E. Jassem ◽

P. Czapiewski ◽

R. Rzepko ◽

...

Keyword(s):

Lung Cancer ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Prognostic Value ◽

Early Stage ◽

Expression Profiles ◽

Microrna Expression ◽

Squamous Cell Lung Cancer

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Platinum Plus Gemcitabine as the Most Effective Regimen in the First Line of Chemotherapy in Advanced Squamous Cell Lung Cancer

10.31038/cst.2017102 ◽

2017 ◽

Vol 2 (1) ◽

Keyword(s):

Lung Cancer ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Squamous Cell Lung Cancer ◽

First Line ◽

Effective Regimen

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Green synthesis of nanomaterials for early lung cancer detection

Journal of Cancer Science and Therapeutics ◽

10.36879/jcst.18.000102 ◽

2018 ◽

pp. 1-1

Keyword(s):

Lung Cancer ◽

Green Synthesis ◽

Cancer Detection ◽

World Wide ◽

Early Stage ◽

Age Groups ◽

Early Lung Cancer ◽

Lung Cancer Detection ◽

Synthesis Of Nanomaterials

Lung cancer is the foremost cause of cancer-related deaths world-wide [1]. It affects 100,000 Americans of the smoking population every year of all age groups, particularly those above 50 years of the smoking population [2]. In India, 51,000 lung cancer deaths were reported in 2012, which include 41,000 men and 10,000 women [3]. It is the leading cause of cancer deaths in men; however, in women, it ranked ninth among all cancerous deaths [4]. It is possible to detect the lung cancer at a very early stage, providing a much higher chance of survival for the patients.

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