Outcomes of Metabolic Surgery

2019 ◽  
pp. 341-351
Author(s):  
Rene Aleman ◽  
Francesco Rubino ◽  
Emanuele Lo Menzo ◽  
Raul J. Rosenthal
Keyword(s):  
Metabolic Surgery

Neurotensin system mediates weight loss response after metabolic surgery

2019 ◽  
Author(s):  
R Chakaroun ◽  
L Scheffler ◽  
S Tabei ◽  
A Tönjes ◽  
M Blüher ◽  
...  
Keyword(s):  
Weight Loss ◽  
Metabolic Surgery

Liver Fibrosis stage at baseline predicts outcome of metabolic surgery

2019 ◽  
Author(s):  
C Kienbacher ◽  
M Wakolbinger ◽  
S Traussnigg ◽  
R Kruschitz ◽  
T Würger ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Metabolic Surgery ◽  
Fibrosis Stage

1157-P: Two-Year Results of Multicenter, Prospective Study of Metabolic Surgery in Obese Type 2 Diabetes Mellitus Subjects in China

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1157-P
Author(s):  
YUQIAN BAO ◽  
HUI LIANG ◽  
PIN ZHANG ◽  
CUNCHUAN WANG ◽  
TAO JIANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Prospective Study ◽  
Metabolic Surgery ◽  
Multicenter Prospective Study

1904-P: Metabolomic Fingerprints after Metabolic Surgery: The STAMPEDE Trial

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1904-P
Author(s):  
WAGNER S. DANTAS ◽  
CHRISTOPHER L. AXELROD ◽  
ADITHYA HARI ◽  
SANGEETA KASHYAP ◽  
PHILIP SCHAUER ◽  
...  
Keyword(s):  
Metabolic Surgery

Presence of Liver Steatosis Is Associated With Greater Diabetes Remission After Gastric Bypass Surgery

2020 ◽  
Author(s):  
Roman Vangoitsenhoven ◽  
Rickesha Wilson ◽  
Deepa V Cherla ◽  
Chao Tu ◽  
Sangeeta R Kashyap ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Metabolic Surgery ◽  
Gastric Bypass Surgery ◽  
Liver Steatosis ◽  
Multivariable Analysis ◽  
Diabetes Remission ◽  
Independent Association ◽  
Glycemic Outcomes ◽  
Design And Methods

<b>Objective</b>: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and beta-cell dysfunction. Ectopic fat accumulation in liver and muscle causes IR. Since bariatric and metabolic surgery significantly improves fatty liver disease, <a>we hypothesized that coexistence of liver steatosis (i.e., when hepatic IR contributes in T2DM) would be associated with greater diabetes improvement after surgery.</a> <p> </p> <p><b>Research design and methods</b>: A total of 519 patients with T2DM who underwent Roux-en-Y gastric bypass and simultaneous liver biopsy and had a minimum 5-year follow-up were analyzed to assess the independent association between biopsy-proven liver steatosis and postoperative long-term diabetes remission (glycated hemoglobin < 6.5% off medications).</p> <p> </p> <p><b>Results</b>: Of the 407 patients with biopsy-proven liver steatosis, long-term diabetes remission was achieved in 211 (52%) patients, compared with 44/112 (39%) remission in patients without steatosis (P=0.027). In multivariable analysis, presence of liver steatosis was an independent predictor of long-term diabetes remission (odds ratio 1.96, [95% confidence interval 1.04 – 3.72], <i>P</i>=0.038). Hepatocyte ballooning, lobular inflammation, or fibrosis at baseline did not predict diabetes remission.</p> <p> </p> <p><b>Conclusion</b>: This study, for the first time, suggests that in patients with T2DM who are considering bariatric and metabolic surgery, coexistence of liver steatosis is associated with better long-term glycemic outcomes. Furthermore, our data suggest that there are different variants of T2DM wherein metabolic responses to surgical weight loss are different. A subgroup of patients whose T2DM is characterized by the presence of hepatic steatosis (presumably associated with worse IR) experience better postoperative metabolic outcomes.</p>

Progress in bariatric-metabolic surgery

2018 ◽  
Vol 31 (2) ◽  
Author(s):  
Hady Razak Hady ◽  
Magdalena Luba ◽  
Mikolaj Czerniawski ◽  
Paweł Wojciak ◽  
Inna Diemieszczyk ◽  
...  
Keyword(s):  
Metabolic Surgery ◽  
Bariatric Metabolic Surgery

Metabolic surgery, a new paradigm for the treatment of diabetes

2019 ◽  
Vol 30 (4) ◽  
pp. 477-485
Author(s):  
R Balongo García ◽  
D Bejarano Gómez-Serna ◽  
A de la Rosa Báez ◽  
D Molina García ◽  
B García del Pino ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Surgery ◽  
New Paradigm ◽  
Calidad De Vida ◽  
Treatment Of Diabetes ◽  
Sistemas Sanitarios

Resumen La diabetes mellitus tipo II (DM2) es una enfermedad crónica, progresiva e incurable, que ocasiona una reducción de la esperanza y de la calidad de vida. Se está produciendo un incremento epidémico global de la misma asociada a la obesidad, y a largo plazo se convertirá en la mayor carga sobre los sistemas sanitarios. Aunque existe un tratamiento efectivo para la diabetes, muchos de los pacientes sólo con el tratamiento médico no consiguen los objetivos terapéuticos mínimos para el control del riesgo microvascular. Las técnicas quirúrgicas para la obesidad mórbida han demostrado que pueden controlar la hiperglucemia, y existe consenso para su uso como forma de tratamiento para algunos pacientes desde 2015. Dado que los objetivos, el tipo de respuesta y los criterios de efectividad no están relacionados directamente con el sobrepeso, estamos ante un nuevo paradigma, definido por el término cirugía metabólica.

Bariatric Surgery as Metabolic Surgery for Diabetic Patients

2014 ◽  
Vol 20 (22) ◽  
pp. 3631-3646 ◽  
Author(s):  
Aristotelis Kalyvas ◽  
Konstantinos Vlachos ◽  
Mohammed Abu-Amara ◽  
John Sampalis ◽  
Georgios Glantzounis
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Surgery ◽  
Diabetic Patients
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