The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development

2020 ◽  
pp. 39-58
Author(s):  
Shahrzad Bahrampour ◽  
Stefan Thor
Keyword(s):  
Drosophila Melanogaster ◽  
Notch Signalling ◽  
Cns Development ◽  
Embryonic Cns

scholarly journals Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster

2009 ◽  
Vol 325 (1) ◽  
pp. 138-150 ◽  
Author(s):  
S.M. Leal ◽  
L. Qian ◽  
H. Lacin ◽  
R. Bodmer ◽  
J.B. Skeath
Keyword(s):  
Drosophila Melanogaster ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Embryonic Cns

scholarly journals The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development

2007 ◽  
Vol 21 (7) ◽  
pp. 744-749 ◽  
Author(s):  
J. Visvanathan ◽  
S. Lee ◽  
B. Lee ◽  
J. W. Lee ◽  
S.-K. Lee
Keyword(s):  
Cns Development ◽  
Embryonic Cns

scholarly journals Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation

Genetics ◽  
2019 ◽  
Vol 213 (4) ◽  
pp. 1111-1144 ◽  
Author(s):  
Stephen T. Crews
Keyword(s):  
Nervous System ◽  
Cell Fate ◽  
Molecular Genetic ◽  
Cell Fate Specification ◽  
Cns Development ◽  
Fate Specification ◽  
The Past ◽  
New Concepts ◽  
Embryonic Cns ◽  
Complex Organ

The Drosophila embryonic central nervous system (CNS) is a complex organ consisting of ∼15,000 neurons and glia that is generated in ∼1 day of development. For the past 40 years, Drosophila developmental neuroscientists have described each step of CNS development in precise molecular genetic detail. This has led to an understanding of how an intricate nervous system emerges from a single cell. These studies have also provided important, new concepts in developmental biology, and provided an essential model for understanding similar processes in other organisms. In this article, the key genes that guide Drosophila CNS development and how they function is reviewed. Features of CNS development covered in this review are neurogenesis, gliogenesis, cell fate specification, and differentiation.

Glia maintain follower neuron survival during Drosophila CNS development

Development ◽  
2000 ◽  
Vol 127 (2) ◽  
pp. 237-244 ◽  
Author(s):  
G.E. Booth ◽  
E.F. Kinrade ◽  
A. Hidalgo
Keyword(s):  
Axon Guidance ◽  
Neuronal Survival ◽  
Cell Number ◽  
Cns Development ◽  
Neuronal Fate ◽  
Missing Gene ◽  
Pioneer Neurons ◽  
Longitudinal Axon ◽  
Glial Function ◽  
Embryonic Cns

While survival of CNS neurons appears to depend on multiple neuronal and non-neuronal factors, it remains largely unknown how neuronal survival is controlled during development. Here we show that glia regulate neuronal survival during formation of the Drosophila embryonic CNS. When glial function is impaired either by mutation of the glial cells missing gene, which transforms glia toward a neuronal fate, or by targeted genetic glial ablation, neuronal death is induced non-autonomously. Pioneer neurons, which establish the first longitudinal axon fascicles, are insensitive to glial depletion whereas the later extending follower neurons die. This differential requirement of neurons for glia is instructive in patterning and links control of cell number with axon guidance during CNS development.

scholarly journals The DOCK Protein Sponge Binds to ELMO and Functions in Drosophila Embryonic CNS Development

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16120 ◽  
Author(s):  
Bridget Biersmith ◽  
Ze Liu ◽  
Kenneth Bauman ◽  
Erika R. Geisbrecht
Keyword(s):  
Cns Development ◽  
Embryonic Cns

scholarly journals Deep Learning Decodes Multi-layered Roles of Polycomb Repressor Complex 2 During Mouse CNS Development

2021 ◽  
Author(s):  
Ariane Mora ◽  
Jonathan Rakar ◽  
Ignacio Monedero Cobeta ◽  
Behzad Yaghmaeian Salmani ◽  
Annika Starkenberg ◽  
...  
Keyword(s):  
Cns Development ◽  
Full Spectrum ◽  
Transcriptomic Response ◽  
Repressor Complex ◽  
Variate Analysis ◽  
Central Nervous Systems ◽  
Embryonic Cns ◽  
Spatio Temporal ◽  
Bioinformatics Workflow

A prominent aspect of most, if not all, central nervous systems (CNSs) is that anterior regions (brain) are larger than posterior ones (spinal cord). Studies in Drosophila and mouse have revealed that the Polycomb Repressor Complex 2 (PRC2) acts by several mechanisms to promote anterior CNS expansion. However, it is unclear if PRC2 acts directly and/or indirectly upon key downstream genes, what the full spectrum of PRC2 action is during embryonic CNS development and how PRC2 integrates with the epigenetic landscape. We removed PRC2 function from the developing mouse CNS, by mutating the key gene Eed, and generated spatio-temporal transcriptomic data. We developed a bioinformatics workflow that incorporates standard statistical analyses with machine learning to integrate the transcriptomic response to PRC2 inactivation with epigenetic information from ENCODE. This multi-variate analysis corroborates the central involvement of PRC2 in anterior CNS expansion, and reveals layered regulation via PRC2. These findings uncover a differential logic for the role of PRC2 upon functionally distinct gene categories that drive CNS anterior expansion. To support the analysis of emerging multi-modal datasets, we provide a novel bioinformatics package that can disentangle regulatory underpinnings of heterogeneous biological processes.

Approaches to identify genes involved inDrosophila embryonic CNS development

1993 ◽  
Vol 24 (6) ◽  
pp. 701-722 ◽  
Author(s):  
Elizabeth Noll ◽  
Lizabeth A. Perkins ◽  
Anthony P. Mahowald ◽  
Norbert Perrimon
Keyword(s):  
Cns Development ◽  
Embryonic Cns
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