scholarly journals Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation

Genetics ◽  
2019 ◽  
Vol 213 (4) ◽  
pp. 1111-1144 ◽  
Author(s):  
Stephen T. Crews
Keyword(s):  
Nervous System ◽  
Cell Fate ◽  
Molecular Genetic ◽  
Cell Fate Specification ◽  
Cns Development ◽  
Fate Specification ◽  
The Past ◽  
New Concepts ◽  
Embryonic Cns ◽  
Complex Organ

The Drosophila embryonic central nervous system (CNS) is a complex organ consisting of ∼15,000 neurons and glia that is generated in ∼1 day of development. For the past 40 years, Drosophila developmental neuroscientists have described each step of CNS development in precise molecular genetic detail. This has led to an understanding of how an intricate nervous system emerges from a single cell. These studies have also provided important, new concepts in developmental biology, and provided an essential model for understanding similar processes in other organisms. In this article, the key genes that guide Drosophila CNS development and how they function is reviewed. Features of CNS development covered in this review are neurogenesis, gliogenesis, cell fate specification, and differentiation.

scholarly journals Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster

2009 ◽  
Vol 325 (1) ◽  
pp. 138-150 ◽  
Author(s):  
S.M. Leal ◽  
L. Qian ◽  
H. Lacin ◽  
R. Bodmer ◽  
J.B. Skeath
Keyword(s):  
Drosophila Melanogaster ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Embryonic Cns

scholarly journals Neuromancer-1 and neuromancer-2 regulate cell fate specification in the embryonic CNS of Drosophila melanogaster

2008 ◽  
Vol 319 (2) ◽  
pp. 467
Author(s):  
Sandra M. Leal ◽  
Li Qian ◽  
Rolf Bodmer ◽  
James B. Skeath
Keyword(s):  
Drosophila Melanogaster ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Embryonic Cns

scholarly journals Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system

2010 ◽  
Vol 127 (1-2) ◽  
pp. 137-145 ◽  
Author(s):  
Ramakrishnan Kannan ◽  
Christian Berger ◽  
Sudharani Myneni ◽  
Gerhard M. Technau ◽  
L.S. Shashidhara
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Fate ◽  
Cyclin E ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans

2020 ◽  
Vol 10 (9) ◽  
pp. 3071-3085
Author(s):  
Wendy Aquino-Nunez ◽  
Zachery E Mielko ◽  
Trae Dunn ◽  
Elise M Santorella ◽  
Ciara Hosea ◽  
...  
Keyword(s):  
Nervous System ◽  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Neural Development ◽  
Nervous System Development ◽  
Cell Fate Specification ◽  
Hox Gene ◽  
Fate Specification

Abstract Identifying the mechanisms behind neuronal fate specification are key to understanding normal neural development in addition to neurodevelopmental disorders such as autism and schizophrenia. In vivo cell fate specification is difficult to study in vertebrates. However, the nematode Caenorhabditis elegans, with its invariant cell lineage and simple nervous system of 302 neurons, is an ideal organism to explore the earliest stages of neural development. We used a comparative transcriptome approach to examine the role of cnd-1/NeuroD1 in C. elegans nervous system development and function. This basic helix-loop-helix transcription factor is deeply conserved across phyla and plays a crucial role in cell fate specification in both the vertebrate nervous system and pancreas. We find that cnd-1 controls expression of ceh-5, a Vax2-like homeobox class transcription factor, in the RME head motorneurons and PVQ tail interneurons. We also show that cnd-1 functions redundantly with the Hox gene ceh-13/labial in defining the fate of DD1 and DD2 embryonic ventral nerve cord motorneurons. These data highlight the utility of comparative transcriptomes for identifying transcription factor targets and understanding gene regulatory networks.

Cell fate specification by even-skipped expression in the Drosophila nervous system is coupled to cell cycle progression

Development ◽  
1995 ◽  
Vol 121 (11) ◽  
pp. 3713-3721 ◽  
Author(s):  
K. Weigmann ◽  
C.F. Lehner
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Cell Fate ◽  
Mother Cell ◽  
Cell Cycle Progression ◽  
S Phase ◽  
Cell Fate Specification ◽  
Cycle Progression ◽  
Fate Specification ◽  
Ganglion Mother Cell

The correct specification of defined neurons in the Drosophila central nervous system is dependent on even-skipped. During CNS development, even-skipped expression starts in the ganglion mother cell resulting from the first asymmetric division of neuroblast NB 1–1. This first division of NB 1–1 (and of the other early neuroblasts as well) is temporally controlled by the transcriptional regulation of string expression, which we have manipulated experimentally, even-skipped expression still occurs if the first neuroblast division is delayed, but not if the division is prohibited. Moreover, even-skipped expression is also dependent on progression through S phase which follows immediately after the first division. However, cytokinesis during the first NB division is not required for even-skipped expression as revealed by observations in pebble mutant embryos. Our results demonstrate therefore that even-skipped expression is coupled to cell cycle progression, presumably in order to prevent a premature activation of expression by a positive regulator which is produced already in the neuroblast during G2 and segregated asymmetrically into the ganglion mother cell during mitosis.

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