Gadolinium-Based Contrast Agents for Breast MRI and Uncertainties About Brain Gadolinium Retention

2020 ◽  
pp. 63-82
Author(s):  
Francesco Sardanelli ◽  
Simone Schiaffino ◽  
Andrea Cozzi ◽  
Luca A. Carbonaro
Keyword(s):  
Contrast Agents ◽  
Breast Mri ◽  
Gadolinium Retention

Screening Breast MRI and Gadolinium Deposition: Cause for Concern?

2021 ◽  
Author(s):  
Colleen H Neal
Keyword(s):  
Breast Cancer ◽  
Renal Function ◽  
Contrast Agents ◽  
Biological Significance ◽  
Breast Mri ◽  
Reliable Data ◽  
Breast Cancer Data ◽  
Cancer Data ◽  
Contrast Enhanced ◽  
Gadolinium Retention

Abstract Gadolinium-based contrast agents (GBCAs) have been used worldwide for over 30 years and have enabled lifesaving diagnoses. Contrast-enhanced breast MRI is frequently used as supplemental screening for women with an elevated lifetime risk of breast cancer. Data have emerged that indicate a fractional amount of administered gadolinium is retained in the bone, skin, solid organs, and brain tissues of patients with normal renal function, although there are currently no reliable data regarding the clinical or biological significance of this retention. Linear GBCAs are associated with a higher risk of gadolinium retention than macrocyclic agents. Over the course of their lives, screened women may receive high cumulative doses of GBCA. Therefore, as breast MRI screening utilization increases, thoughtful use of GBCA is indicated in this patient population.

scholarly journals Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents

Radiology ◽  
2017 ◽  
Vol 285 (3) ◽  
pp. 839-849 ◽  
Author(s):  
Eliana Gianolio ◽  
Paola Bardini ◽  
Francesca Arena ◽  
Rachele Stefania ◽  
Enza Di Gregorio ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Rat Brain ◽  
Repeated Administration ◽  
Gadolinium Complexes ◽  
Gadolinium Retention

scholarly journals Gadolinium retention and clearance after administration of macrocyclic magnetic resonance contrast agents to rats

2019 ◽  
Vol 49 (8) ◽  
pp. 1110-1111 ◽  
Author(s):  
Simona Bussi ◽  
Federico Maisano ◽  
Fabio Tedoldi ◽  
Miles A. Kirchin
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Magnetic Resonance Contrast ◽  
Gadolinium Retention ◽  
Resonance Contrast

Gadolinium Retention in Erythrocytes and Leukocytes From Human and Murine Blood Upon Treatment With Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging

2020 ◽  
Vol 55 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Enza Di Gregorio ◽  
Chiara Furlan ◽  
Sandra Atlante ◽  
Rachele Stefania ◽  
Eliana Gianolio ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Gadolinium Retention

scholarly journals Linear Gadolinium-Based Contrast Agents Are Associated With Brain Gadolinium Retention in Healthy Rats

2016 ◽  
Vol 51 (2) ◽  
pp. 73-82 ◽  
Author(s):  
Philippe Robert ◽  
Xavier Violas ◽  
Sylvie Grand ◽  
Stéphane Lehericy ◽  
Jean-Marc Idée ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Gadolinium Retention

scholarly journals Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis

2019 ◽  
Vol 40 (8) ◽  
pp. 1265-1273 ◽  
Author(s):  
Y. Forslin ◽  
J. Martola ◽  
Å. Bergendal ◽  
S. Fredrikson ◽  
M.K. Wiberg ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Contrast Agents ◽  
Gadolinium Retention ◽  
The Brain

scholarly journals Biological effects of MRI contrast agents: gadolinium retention, potential mechanisms and a role for phosphorus

2017 ◽  
Vol 375 (2107) ◽  
pp. 20170180 ◽  
Author(s):  
Joel Garcia ◽  
Stephen Z. Liu ◽  
Angelique Y. Louie
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Biological Effects ◽  
Blood Pool ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Treatment Regimens ◽  
Gadolinium Retention ◽  
Magnetic Resonance Imaging Mri ◽  
Blood Pool Agents

No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room—which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens. More recently, inert blood pool agents have been found to deposit in the brain. Release of free metal is often suspected as the culprit but that hypothesis has yet to be validated. In addition, even innocuous agents can cause painful side effects during injection in some patients. In this brief review, we summarize known biological effects for gadolinium- and iron-based MRI contrast agents, and discuss some of the potential mechanisms for the observed biological effects, including the potential role of phosphorus imbalance, related to kidney disease or cancer, in destabilizing gadolinium-based chelates and precipitating free gadolinium. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.

Impact of Impaired Renal Function on Gadolinium Retention After Administration of Gadolinium-Based Contrast Agents in a Mouse Model

2016 ◽  
Vol 51 (10) ◽  
pp. 655-660 ◽  
Author(s):  
A. Adhipatria P. Kartamihardja ◽  
Takahito Nakajima ◽  
Satomi Kameo ◽  
Hiroshi Koyama ◽  
Yoshito Tsushima
Keyword(s):  
Renal Function ◽  
Mouse Model ◽  
Contrast Agents ◽  
Impaired Renal Function ◽  
Gadolinium Retention
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