A Novel Approach to Collectively Determine Cybersecurity Performance Benchmark Data

Author(s):  
Richard Baskerville ◽  
Vijay Vaishnavi
Author(s):  
S. Shanthi ◽  
V. Murali Bhaskaran

This study uses data mining techniques for computer-aided diagnosis that involves the feature extraction for cancer detection, so as to help doctors towards making optimal decisions quickly and accurately. Features play an important role in detecting the cancer in the digital mammogram and feature extraction stage is the most vital and difficult stage. In this paper, an enhanced feature extraction method named Multiscale Surrounding Region Dependence Method (MSRDM) is proposed to be effective in classifying the mammogram images into normal or benign or malignant. This proposed system is based on a four-step procedure: Regions of Interest specification, two dimensional discrete wavelet transformation, and multiscale surrounding region dependence matrix computation and feature extraction. The performance of the proposed feature set is compared with the conventional texture-analysis methods such as gray level cooccurence matrix features and surrounding region dependence method features. Experiments have been conducted on both real and benchmark data and the results have been proved to be progressive.


1999 ◽  
Author(s):  
John L. Zych ◽  
Scott A. Adamick ◽  
Daniel K. Jones ◽  
Dru M. Wilson ◽  
Wayne A. Boyer

Abstract Nondestructive and destructive testing are vital in the composite material industry to determine the mechanical properties of different designs. This paper presents a novel approach to measuring the mechanical peel strength that may be used for a variety of fiberglass foam core sandwiches. The objective of this study was to develop a testing method that was simple and easily reproduced in other laboratories. The goal was to measure the mechanical peel strength using a device that may be used for a variety of sample sizes and materials. An additional goal was to provide benchmark data on the mechanical peel strength of two particular composite designs. The new testing method may have applications to a wide range of composite structures, and it may eventually lead to a new ASTM standard.


2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.


2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687


2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
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