Predicting Hospital Readmission Using Graph Representation Learning Based on Patient and Disease Bipartite Graph

Author(s):  
Zhiqi Liu ◽  
Lizhen Cui ◽  
Wei Guo ◽  
Wei He ◽  
Hui Li ◽  
...  
2021 ◽  
Vol 4 ◽  
Author(s):  
David Gordon ◽  
Panayiotis Petousis ◽  
Henry Zheng ◽  
Davina Zamanzadeh ◽  
Alex A.T. Bui

We present a novel approach for imputing missing data that incorporates temporal information into bipartite graphs through an extension of graph representation learning. Missing data is abundant in several domains, particularly when observations are made over time. Most imputation methods make strong assumptions about the distribution of the data. While novel methods may relax some assumptions, they may not consider temporality. Moreover, when such methods are extended to handle time, they may not generalize without retraining. We propose using a joint bipartite graph approach to incorporate temporal sequence information. Specifically, the observation nodes and edges with temporal information are used in message passing to learn node and edge embeddings and to inform the imputation task. Our proposed method, temporal setting imputation using graph neural networks (TSI-GNN), captures sequence information that can then be used within an aggregation function of a graph neural network. To the best of our knowledge, this is the first effort to use a joint bipartite graph approach that captures sequence information to handle missing data. We use several benchmark datasets to test the performance of our method against a variety of conditions, comparing to both classic and contemporary methods. We further provide insight to manage the size of the generated TSI-GNN model. Through our analysis we show that incorporating temporal information into a bipartite graph improves the representation at the 30% and 60% missing rate, specifically when using a nonlinear model for downstream prediction tasks in regularly sampled datasets and is competitive with existing temporal methods under different scenarios.


2021 ◽  
Vol 13 (3) ◽  
pp. 526
Author(s):  
Shengliang Pu ◽  
Yuanfeng Wu ◽  
Xu Sun ◽  
Xiaotong Sun

The nascent graph representation learning has shown superiority for resolving graph data. Compared to conventional convolutional neural networks, graph-based deep learning has the advantages of illustrating class boundaries and modeling feature relationships. Faced with hyperspectral image (HSI) classification, the priority problem might be how to convert hyperspectral data into irregular domains from regular grids. In this regard, we present a novel method that performs the localized graph convolutional filtering on HSIs based on spectral graph theory. First, we conducted principal component analysis (PCA) preprocessing to create localized hyperspectral data cubes with unsupervised feature reduction. These feature cubes combined with localized adjacent matrices were fed into the popular graph convolution network in a standard supervised learning paradigm. Finally, we succeeded in analyzing diversified land covers by considering local graph structure with graph convolutional filtering. Experiments on real hyperspectral datasets demonstrated that the presented method offers promising classification performance compared with other popular competitors.


Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2111
Author(s):  
Bo-Wei Zhao ◽  
Zhu-Hong You ◽  
Lun Hu ◽  
Zhen-Hao Guo ◽  
Lei Wang ◽  
...  

Identification of drug-target interactions (DTIs) is a significant step in the drug discovery or repositioning process. Compared with the time-consuming and labor-intensive in vivo experimental methods, the computational models can provide high-quality DTI candidates in an instant. In this study, we propose a novel method called LGDTI to predict DTIs based on large-scale graph representation learning. LGDTI can capture the local and global structural information of the graph. Specifically, the first-order neighbor information of nodes can be aggregated by the graph convolutional network (GCN); on the other hand, the high-order neighbor information of nodes can be learned by the graph embedding method called DeepWalk. Finally, the two kinds of feature are fed into the random forest classifier to train and predict potential DTIs. The results show that our method obtained area under the receiver operating characteristic curve (AUROC) of 0.9455 and area under the precision-recall curve (AUPR) of 0.9491 under 5-fold cross-validation. Moreover, we compare the presented method with some existing state-of-the-art methods. These results imply that LGDTI can efficiently and robustly capture undiscovered DTIs. Moreover, the proposed model is expected to bring new inspiration and provide novel perspectives to relevant researchers.


Author(s):  
Leon Hetzel ◽  
David S. Fischer ◽  
Stephan Günnemann ◽  
Fabian J. Theis

2021 ◽  
Vol 11 (10) ◽  
pp. 4497
Author(s):  
Dongming Chen ◽  
Mingshuo Nie ◽  
Jie Wang ◽  
Yun Kong ◽  
Dongqi Wang ◽  
...  

Aiming at analyzing the temporal structures in evolutionary networks, we propose a community detection algorithm based on graph representation learning. The proposed algorithm employs a Laplacian matrix to obtain the node relationship information of the directly connected edges of the network structure at the previous time slice, the deep sparse autoencoder learns to represent the network structure under the current time slice, and the K-means clustering algorithm is used to partition the low-dimensional feature matrix of the network structure under the current time slice into communities. Experiments on three real datasets show that the proposed algorithm outperformed the baselines regarding effectiveness and feasibility.


Author(s):  
Jie Cheng ◽  
Lu Lian ◽  
Zichen Xu ◽  
Dan Wu ◽  
Haoyang Zhu ◽  
...  

Author(s):  
Yizhu Jiao ◽  
Yun Xiong ◽  
Jiawei Zhang ◽  
Yao Zhang ◽  
Tianqi Zhang ◽  
...  

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