Body Map Pathway: Visual Guidance of Human Body to Diagnosis Efficiently

Automatic organ detection for radiotherapy planning by standard human body map

International Congress Series ◽

10.1016/j.ics.2005.03.102 ◽

2005 ◽

Vol 1281 ◽

pp. 1290

Author(s):

Nobuhiro Tsukamoto ◽

Yutaka Ando ◽

Masayuki Kitamura ◽

Osamu Kawaguchi ◽

Teisuke Hashimoto ◽

...

Keyword(s):

Human Body ◽

Radiotherapy Planning ◽

Body Map

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On the whereabouts of SARS-CoV-2 in the human body: A systematic review

PLoS Pathogens ◽

10.1371/journal.ppat.1009037 ◽

2020 ◽

Vol 16 (10) ◽

pp. e1009037 ◽

Cited By ~ 4

Author(s):

Wim Trypsteen ◽

Jolien Van Cleemput ◽

Willem van Snippenberg ◽

Sarah Gerlo ◽

Linos Vandekerckhove

Keyword(s):

Systematic Review ◽

Human Body ◽

Body Fluids ◽

Current View ◽

Viral Shedding ◽

Multiple Organs ◽

Body Map ◽

Viral Components ◽

Cell Expression ◽

Entry Receptor

Since SARS-CoV-2 appeared in the human population, the scientific community has scrambled to gather as much information as possible to find good strategies for the containment and treatment of this pandemic virus. Here, we performed a systematic review of the current (pre)published SARS-CoV-2 literature with a focus on the evidence concerning SARS-CoV-2 distribution in human tissues and viral shedding in body fluids. In addition, this evidence is aligned with published ACE2 entry-receptor (single cell) expression data across the human body to construct a viral distribution and ACE2 receptor body map. We highlight the broad organotropism of SARS-CoV-2, as many studies identified viral components (RNA, proteins) in multiple organs, including the pharynx, trachea, lungs, blood, heart, vessels, intestines, brain, male genitals and kidneys. This also implicates the presence of viral components in various body fluids such as mucus, saliva, urine, cerebrospinal fluid, semen and breast milk. The main SARS-CoV-2 entry receptor, ACE2, is expressed at different levels in multiple tissues throughout the human body, but its expression levels do not always correspond with SARS-CoV-2 detection, indicating that there is a complex interplay between virus and host. Together, these data shed new light on the current view of SARS-CoV-2 pathogenesis and lay the foundation for better diagnosis and treatment of COVID-19 patients.

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A statistical nonparametric method for identifying consistently important features across samples

10.1101/833624 ◽

2019 ◽

Author(s):

Natalie Sauerwald ◽

Carl Kingsford

Keyword(s):

Human Body ◽

Simulated Data ◽

Housekeeping Genes ◽

Housekeeping Gene ◽

False Positives ◽

Supplementary Information ◽

Sequencing Data ◽

Data Types ◽

Link Type ◽

Body Map

AbstractIn many applications, a consistently high measurement across many samples can indicate particularly meaningful or useful information for quality control or biological interpretation. Identification of these strong features among many others can be challenging especially when the samples cannot be expected to have the same distribution or range of values. We present a general method called conserved feature discovery (CFD) for identifying features with consistently strong signals across multiple conditions or samples. Given any real-valued data, CFD requires no parameters, makes no assumptions on the shape of the underlying sample distributions, and is robust to differences across these distributions.We show that with high probability CFD identifies all true positives and no false positives under certain assumptions on the median and variance distributions of the feature measurements. Using simulated data, we show that CFD is tolerant to a small percentage of poor quality samples and robust to false positives. Applying CFD to RNA sequencing data from the Human Body Map project and GTEx, we identify housekeeping genes as highly expressed genes across tissue types and compare to housekeeping gene lists from previous methods. CFD is consistent between the Human Body Map and GTEx data sets, and identifies lists of genes enriched for basic cellular processes as expected. The framework can be easily adapted for many data types and desired feature properties.AvailabilityCode for CFD and scripts to reproduce the figures and analysis in this work are available at https://github.com/Kingsford-Group/cfd.Supplementary informationSupplementary data are available at https://github.com/Kingsford-Group/cfd.

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Microstructural comparison of synthetic bioceramics with natural bioceramics

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100084491 ◽

1991 ◽

Vol 49 ◽

pp. 38-39

Author(s):

Shulin Wen ◽

Jingwei Feng ◽

A. Krajewski ◽

A. Ravaglioli

Keyword(s):

Recent Work ◽

Human Body ◽

Human Tissues ◽

Main Constituent ◽

Laboratory Furnace ◽

Chinese Adult ◽

Human Enamel ◽

Biological Compatibility ◽

Synthetic Hydroxyapatite ◽

Synthetic Work

Hydroxyapatite bioceramics has attracted many material scientists as it is the main constituent of the bone and the teeth in human body. The synthesis of the bioceramics has been performed for years. Nowadays, the synthetic work is not only focused on the hydroapatite but also on the fluorapatite and chlorapatite bioceramics since later materials have also biological compatibility with human tissues; and they may also be very promising for clinic purpose. However, in comparison of the synthetic bioceramics with natural one on microstructure, a great differences were observed according to our previous results. We have investigated these differences further in this work since they are very important to appraise the synthetic bioceramics for their clinic application.The synthetic hydroxyapatite and chlorapatite were prepared according to A. Krajewski and A. Ravaglioli and their recent work. The briquettes from different hydroxyapatite or chlorapatite powders were fired in a laboratory furnace at the temperature of 900-1300°C. The samples of human enamel selected for the comparison with synthetic bioceramics were from Chinese adult teeth.

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Study on erythrocytes by SEM photogrammetry (SEMP) technique

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100161187 ◽

1990 ◽

Vol 48 (3) ◽

pp. 724-725

Author(s):

Tong Wensheng ◽

Lu Lianhuang ◽

Zhang Zhijun

Keyword(s):

Quantitative Analysis ◽

Cell Membrane ◽

Clinical Diagnosis ◽

Human Body ◽

Blood Cells ◽

Three Dimensional ◽

Normal Person ◽

Blood Disease ◽

Computation Technique ◽

Important Basis

This is a combined study of two diffirent branches, photogrammetry and morphology of blood cells. The three dimensional quantitative analysis of erythrocytes using SEMP technique, electron computation technique and photogrammetry theory has made it possible to push the study of mophology of blood cells from LM, TEM, SEM to a higher stage, that of SEM P. A new path has been broken for deeply study of morphology of blood cells.In medical view, the abnormality of the quality and quantity of erythrocytes is one of the important changes of blood disease. It shows the abnormal blood—making function of the human body. Therefore, the study of the change of shape on erythrocytes is the indispensable and important basis of reference in the clinical diagnosis and research of blood disease.The erythrocytes of one normal person, three PNH Patients and one AA patient were used in this experiment. This research determines the following items: Height;Length of two axes (long and short), ratio; Crevice in depth and width of cell membrane; Circumference of erythrocytes; Isoline map of erythrocytes; Section map of erythrocytes.

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