Neoadjuvant Chemotherapy

2021 ◽  
pp. 245-250
Author(s):  
Brandon Bernard ◽  
Thomas W. Flaig
Keyword(s):  
Neoadjuvant Chemotherapy

1317: Significance of Lymph Node Positive Disease in Patients Treated with Neoadjuvant Chemotherapy: Is Adjuvant Chemotherapy Beneficial?

2005 ◽  
Vol 173 (4S) ◽  
pp. 358-358
Author(s):  
Wassim Kassouf ◽  
Dan Leibovici ◽  
Xian Zhou ◽  
Colin P.N. Dinney ◽  
G.H. Barton ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Neoadjuvant Chemotherapy ◽  
Node Positive ◽  
Node Positive Disease ◽  
Lymph Node Positive

Response Evaluation of Neoadjuvant Chemotherapy in Patients with Epithelial Malignancies of the Paranasal Sinus

2012 ◽  
Vol 73 (S 02) ◽  
Author(s):  
D. Nair ◽  
P. Pai ◽  
K. Prabhash ◽  
A. Moiyadi ◽  
P. Pal ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Paranasal Sinus ◽  
Response Evaluation

Modern Possibilities of Organ-Preserving Treatment in Children with Intraocular Retinoblastoma

2018 ◽  
Vol 5 (3) ◽  
pp. 175-187 ◽  
Author(s):  
O. V. Gorovtsova ◽  
T. L. Ushakova ◽  
V. G. Polyakov
Keyword(s):  
Drug Delivery ◽  
Survival Rate ◽  
Cancer Therapy ◽  
Neoadjuvant Chemotherapy ◽  
Patient Survival ◽  
Focal Therapy ◽  
Local Drug Delivery ◽  
Large Size ◽  
Intraocular Retinoblastoma

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.

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