Fundamental Concepts in Regenerative Medicine: Structural Fat Grafting (SFG) and Platelet-Rich Plasma (PRP)

Bone regenerative medicine (BRM) aims to overcome the limitations of conventional treatments for critical bone defects by developing therapeutic strategies, based on temporary bioactive substitutes, capable of stimulating, sustaining, and guiding tissue regeneration. The aim of this study was to validate the “proof of concept” of a cellularized bioactive scaffold and establish its potential for use in BRM. For this purpose, three-dimensional scaffolds of poly-(lactic acid) (PLA), produced by the additive manufacturing technique, were incorporated into a human platelet-rich plasma (PRP-h) fibrin matrix containing human infrapatellar fat pad mesenchymal stem cells (hIFPMSC). The scaffolds (PLA/finbrin-bioactive) were kept under ideal culture conditions in a medium free from fetal bovine serum and analyzed at 5 and 10 days by Scanning Electron Microscopy (SEM), Fourrier Transform Infrared (FTIR), Circular Dichroism and fluorescence microscopy. The results demonstrated the feasibility of obtaining a rigid, cytocompatible, and cellularized three-dimensional structure. In addition, PRP platelets and leukocytes were able to provide a bioactive environment capable of maintaining the viability of hIFPMSC into scaffolds. The results validate the concept of a customizable, bioactive, cellularized, and non-immunogenic strategy for application in BRM.

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The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

Aesthetic Plastic Surgery ◽

10.1007/s00266-018-1293-9 ◽

2018 ◽

Vol 43 (3) ◽

pp. 803-814 ◽

Cited By ~ 14

Author(s):

Pouria Samadi ◽

Mohsen Sheykhhasan ◽

Hamed Manoochehri Khoshinani

Keyword(s):

Regenerative Medicine ◽

Platelet Rich Plasma ◽

Comprehensive Review

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Magnetic Resonance Imaging and Ultrasound Evaluation after Breast Autologous Fat Grafting Combined with Platelet-Rich Plasma

Plastic & Reconstructive Surgery ◽

10.1097/prs.0000000000000141 ◽

2014 ◽

Vol 133 (5) ◽

pp. 716e-718e

Author(s):

Sara Di Lorenzo ◽

Bartolo Corradino ◽

Adriana Cordova

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Platelet Rich Plasma ◽

Fat Grafting ◽

Resonance Imaging ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Ultrasound Evaluation

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Platelet-rich plasma in regenerative medicine

Biomedical Research and Therapy ◽

10.7603/s40730-014-0005-6 ◽

2014 ◽

Vol 1 (1) ◽

Cited By ~ 2

Author(s):

Guhta Ra Hara ◽

Thaha Basu

Keyword(s):

Regenerative Medicine ◽

Platelet Rich Plasma

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Safety of Aesthetic Medicine Procedures in Patients with Autoimmune Thyroid Disease: A Literature Review

Medicina ◽

10.3390/medicina58010030 ◽

2021 ◽

Vol 58 (1) ◽

pp. 30

Author(s):

Kamil Adamczyk ◽

Ewa Rusyan ◽

Edward Franek

Keyword(s):

Platelet Rich Plasma ◽

Fat Grafting ◽

Thyroid Diseases ◽

Autoimmune Thyroid Diseases ◽

Aesthetic Medicine ◽

Autoimmune Thyroid ◽

Wide Range ◽

Organ Specific ◽

Safety Studies ◽

Potential Possibility

Autoimmune thyroid diseases are the most common organ-specific autoimmune diseases, affecting 2–5% of the world’s population. Due to the autoimmune background of thyroid diseases, we analyzed a wide range of cosmetic procedures, from minimally invasive cosmetic injections (mesotherapy) to highly invasive procedures, such as lifting threads. Out of the seven categories of treatments in aesthetic medicine analyzed by us—hyaluronic acid, botulinum toxin, autologous platelet-rich plasma, autologous fat grafting, lifting threads, IPL and laser treatment and mesotherapy—only two, mesotherapy and lifting threads, are not recommended. This is due to the lack of safety studies and the potential possibility of a higher frequency of side effects in patients with autoimmune thyroid diseases.

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