scholarly journals Systematic review of the efficacy of fat grafting and platelet-rich plasma for wound healing

2018 ◽  
Vol 15 (4) ◽  
pp. 519-526 ◽  
Author(s):  
Oliver J Smith ◽  
Muholan Kanapathy ◽  
Ankur Khajuria ◽  
Max Prokopenko ◽  
Nadine Hachach-Haram ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Fat Grafting

scholarly journals Protocol for a systematic review of the efficacy of fat grafting and platelet-rich plasma for wound healing

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Oliver J. Smith ◽  
Muholan Kanapathy ◽  
Ankur Khajuria ◽  
Max Prokopenko ◽  
Nadine Hachach-Haram ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Fat Grafting

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

scholarly journals Fat grafting and platelet-rich plasma in wound healing: a review of histology from animal studies

Adipocyte ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 80-90
Author(s):  
Grant S. Nolan ◽  
Oliver J. Smith ◽  
Gavin Jell ◽  
Afshin Mosahebi
Keyword(s):  
Wound Healing ◽  
Animal Studies ◽  
Platelet Rich Plasma ◽  
Fat Grafting

Effectiveness of platelet-rich plasma therapy in wound healing of pilonidal sinus surgery: A comprehensive systematic review and meta-analysis

2017 ◽  
Vol 25 (6) ◽  
pp. 1002-1007 ◽  
Author(s):  
Shayan Mostafaei ◽  
Fatemeh Norooznezhad ◽  
Saeed Mohammadi ◽  
Amir Hossein Norooznezhad
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Pilonidal Sinus ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Sinus Surgery ◽  
Plasma Therapy

scholarly journals Comparison of the Efficacy and Safety of Cell-Assisted Lipotransfer and Platelet-Rich Plasma Assisted Lipotransfer: What Should We Expect from a Systematic Review with Meta-Analysis?

2021 ◽  
Vol 30 ◽  
pp. 096368972198960
Author(s):  
Aizhen Chen ◽  
Li Zhang ◽  
Penghong Chen ◽  
Chaoyu Zhang ◽  
Shijie Tang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Survival Rate ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Fat Grafting ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Fat Survival

Due to the high absorption rate of traditional autologous fat grafting, cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer were developed. The purpose of this article was to evaluate the efficacy and safety of CAL and PRP in promoting the survival of autologous fat grafting through systematic review and meta-analysis. We searched Pubmed, Cochrane Library, Web of Science, and EMBASE for clinical studies on CAL and PRP-assisted lipotransfer published from January 2010 to January 2020. Then a meta-analysis was performed to assess the efficacy of CAL and PRP-assisted lipotransfer through data analysis of fat survival rate. We also assessed the incidence of complications and multiple operations to analyze their safety. A total of 36 studies (1697 patients) were included in this review. Regardless of the recipient area, CAL and PRP-assisted lipotransfer significantly improved the fat survival rate (CAL vs non-CAL: 71% vs 48%, P < 0.0001; PRP vs non-PRP: 70% vs 40%, P < 0.0001; CAL vs PRP: 71% vs 70%, P = 0.7175). However, in large-volume fat grafting, such as breast reconstruction, both increased the incidence of complications and did not decrease the frequency of multiple operations after lipotransfer. Further prospective studies are needed to evaluate the clinical benefits of CAL and PRP-assisted lipotransfer.

scholarly journals The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review

2018 ◽  
Vol 4 ◽  
pp. 205951311880877 ◽  
Author(s):  
Osaid H Alser ◽  
Ioannis Goutos
Keyword(s):  
Wound Healing ◽  
Literature Review ◽  
Management Practice ◽  
Platelet Rich Plasma ◽  
English Literature ◽  
Current Data ◽  
Fat Grafting ◽  
High Concentration ◽  
Scar Management ◽  
Autologous Platelet

Introduction: Autologous platelet-based concentrates represent increasingly popular adjuncts to a variety of medical, surgical and aesthetic interventions. Their beneficial potential rests on the ability to deliver a high concentration of growth factors to the target tissues. There are currently no reports in the literature appraising the evidence behind the use of platelet-rich plasma (PRP) in scar management. Methods: A detailed English literature review was conducted using PubMed Medline, Embase and Web of Science; the manuscripts were appraised and classified according to the Joanna Briggs Institute Levels of evidence. The results are presented in descending order of evidence separately for atrophic, keloid, surgical and traumatic scars. Discussion: On the basis of level 1 evidence currently available, it appears that PRP can improve the quality of atrophic acne scars treated with ablative fractional CO2 laser and decrease the duration of laser-related side effects including oedema and erythema. Regarding surgical scars, the current data suggest that PRP may improve wound healing and early scar quality; furthermore, incorporation of PRP in fat-grafting procedures undertaken in conjunction with non-ablative, fractional laser can contribute to better wound healing as well as a significant improvement in texture, colour and contour in traumatic scar resurfacing. There are no high level studies at present to support the incorporation of autologous platelet-based concentrates in the management of keloid scars. Conclusion: PRP is a promising adjunct in scar management practice. Further research with long-term follow-up is warranted to delineate the value of this modality in different subtypes of scars.

scholarly journals Protocol for a systematic review of autologous fat grafting for wound healing

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Joshua Luck ◽  
Oliver J. Smith ◽  
Dean Malik ◽  
Afshin Mosahebi
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Autologous Fat
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