Clinical Cases Debate: Neoadjuvant Versus Adjuvant Immunotherapy in Localized Renal Cell Carcinoma (RCC)

2022 ◽  
pp. 187-205
Author(s):  
William Paul Skelton ◽  
Aaron Dahmen ◽  
Monica Chatwal ◽  
Rohit K. Jain ◽  
Jad Chahoud ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Adjuvant Immunotherapy ◽  
Localized Renal Cell Carcinoma ◽  
Clinical Cases

908: Preoperative C-Reactive Protein Elevation as a Predictor of Localized Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 301-301
Author(s):  
Yasumasa Iimura ◽  
Kazutaka Saito ◽  
Minato Yokoyama ◽  
Hitoshi Masuda ◽  
Tsuyoshi Kobayashi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Localized Renal Cell Carcinoma

scholarly journals Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

Metabolites ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 10
Author(s):  
Corina Daniela Ene ◽  
Mircea Nicolae Penescu ◽  
Simona Roxana Georgescu ◽  
Mircea Tampa ◽  
Ilinca Nicolae
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Posttranslational Modifications ◽  
Renal Cell ◽  
Clear Cell ◽  
Initial Point ◽  
Cell Renal Cell Carcinoma ◽  
Total Sialic Acid ◽  
Advanced Stages ◽  
Localized Renal Cell Carcinoma

Posttranslational modifications are dynamic enzymatic-mediated processes, regulated in time and space, associated with cancer development. We aimed to evaluate the significance of posttranslational modifications in the pathogenesis of clear cell renal cell carcinoma. The authors developed a prospective, observational study during a period of three years and included 55 patients with localized renal cell carcinoma and 30 heathy subjects. Glycosylation, nitration and carbonylation, thiol-disulfide homeostasis, methylation, phosphorylation and proteolytic cleavage were evaluated in the serum of the evaluated subjects in the present study. Our results showed some characteristics for early ccRCC: high production of cytokines, substrate hypersialylation, induced nitrosative and carbonylic stress, arginine hypermethylation, thiol/disulfide homeostasis (TDH) alteration, the regulatory role of soluble receptors (sRAGE, sIL-6R) in RAGE and IL-6 signaling, the modulatory effect of TK-1and TuM2-PK in controlling the level of phosphometabolites in neoplastic cells. These data could be the initial point for development of a panel of biomarkers such as total sialic acid, orosomucoids, nitrotyrosine, carbonylic metabolites, ADMA, SDMA, and thiol-disulfide equilibrium for early diagnosis of ccRCC. Moreover, they could be considered a specific disease PTM signature which underlines the transition from early to advanced stages in this neoplasia, and of a therapeutic target in kidney oncogenesis.

Characterization of Clinical Cases of Advanced Papillary Renal Cell Carcinoma via Comprehensive Genomic Profiling

2018 ◽  
Vol 73 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Sumanta K. Pal ◽  
Siraj M. Ali ◽  
Evgeny Yakirevich ◽  
Daniel M. Geynisman ◽  
Jose A. Karam ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Genomic Profiling ◽  
Comprehensive Genomic Profiling ◽  
Clinical Cases

ONCOLOGICAL EFFICACY OF RETROPERITONEOSCOPIC RADICAL NEPHRECTOMY COMPARED TO OPEN RADICAL NEPHRECTOMY FOR LOCALIZED RENAL CELL CARCINOMA < 7CM

2009 ◽  
Vol 181 (4S) ◽  
pp. 464-465
Author(s):  
Thomas Hermanns ◽  
Räto T Strebel ◽  
Georg Müller ◽  
Michael Müntener ◽  
Boris Weltzin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Radical Nephrectomy ◽  
Open Radical Nephrectomy ◽  
Localized Renal Cell Carcinoma
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