ABSTRACT
Deciduomal growth was stimulated in rats by inserting a silk thread into the lumen of one uterine horn on day 5 of pseudopregnancy. The degree of response was evaluated at autopsy on day 9. Deciduomal growth under such conditions was found to be reduced by the administration of methallibure (I. C. I. 33,828), 100 mg/kg p. o., on days 2 to 4 or – to a lesser extent – on days 4 to 6. Additional treatments with oestrone, 1 μg/rat and/or progesterone, 2 mg/rat, given subcutaneously on various days during and after administration of methallibure on days 2 to 4, failed to restore deciduomal growth to normal levels. This was achieved, however, when methallibure was given on days 4 to 6, by additional treatment with progesterone on days 4 to 7 combined with oestrone on days 4, 4 and 5, or 4 to 7, although neither progesterone nor oestrone was effective alone.
These results indicate that the administration of methallibure reduces the output of both oestrogen and progesterone from the ovary to levels below those required for normal deciduomal growth. They also suggest that this effect persists for more than 2 days after administration of the compound is stopped.
Geometric Modelling of Added Layers by Coaxial Laser Cladding
